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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Wnt3
wingless-type MMTV integration site family, member 3
MGI:98955
29 phenotypes from 4 alleles in 4 genetic backgrounds
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Allelic Composition
Genetic Background		 Annotated Term Reference
Wnt3tm1Amc/Wnt3tm1Amc
involves: 129S7/SvEvBrd 		absent limbs J:81795
embryonic lethality during organogenesis J:81795
failure to gastrulate J:81795
Wnt3tm1Amc/Wnt3tm2Amc
Tg(Msx2-cre)5Rem/0
involves: 129S1/Sv * 129S7/SvEvBrd * 129X1/SvJ 		abnormal apical ectodermal ridge morphology J:81795
abnormal autopod morphology J:81795
abnormal forelimb morphology J:81795
abnormal hindlimb morphology J:81795
absent hindlimb J:81795
increased ectoderm apoptosis J:81795
short hindlimb J:81795
thin apical ectodermal ridge J:81795
Wnt3tm1Amc/Wnt3tm2Amc
Tg(Rarb-cre)1Mrc/0
involves: 129S1/Sv * 129S7/SvEvBrd * 129X1/SvJ 		abnormal apical ectodermal ridge morphology J:81795
abnormal forelimb morphology J:81795
Wnt3tm1Brd/Wnt3tm1Brd
involves: 129S7/SvEvBrd * C57BL/6J 		abnormal ectoderm development J:56511
abnormal embryo size J:56511
abnormal embryonic epiblast morphology J:56511
abnormal extraembryonic endoderm formation J:56511
abnormal extraembryonic tissue morphology J:56511
abnormal germ layer development J:56511
abnormal rostral-caudal axis patterning J:56511
absent allantois J:56511
absent amnion J:56511
absent amniotic folds J:56511
absent chorion J:56511
absent limbs J:56511
absent mesoderm J:56511
absent primitive node J:56511
absent visceral yolk sac J:56511
disorganized embryonic tissue J:56511
embryonic lethality during organogenesis, complete penetrance J:56511
failure of primitive streak formation J:56511
failure to gastrulate J:56511
Wnt3tm2a(EUCOMM)Wtsi/Wnt3tm2a(EUCOMM)Wtsi
C57BL/6N-Wnt3tm2a(EUCOMM)Wtsi/Wtsi 		preweaning lethality, complete penetrance J:211773
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory