Wnt4 Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Wnt4
wingless-type MMTV integration site family, member 4
MGI:98957

68 phenotypes from 11 alleles in 11 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Amhr2^tm3(cre)Bhr/Amhr2⁺ Wnt4^tm1Amc/Wnt4^tm1.1Bhr involves: 129S1/Sv * 129S7/SvEvBrd * C57BL/6J	normal reproductive system phenotype	J:171430
Amhr2^tm3(cre)Bhr/Amhr2⁺ Wnt4^tm1.1Boer/Wnt4^tm1.2Boer involves: 129S1/Sv * 129S4/SvJae * 129S7/SvEvBrd * 129X1/SvJ	abnormal kidney development	J:162337
	abnormal ovary development	J:162337
	decreased litter size	J:162337
	decreased mature ovarian follicle number	J:162337
	decreased ovary weight	J:162337
	decreased renal glomerulus number	J:162337
	disheveled coat	J:162337
	postnatal growth retardation	J:162337
	premature death	J:162337
Gt(ROSA)26Sor^tm1(Wnt4)Bhr/Gt(ROSA)26Sor⁺ Tg(Col2a1-cre)1Bhr/0 involves: 129S7/SvEvBrd * C57BL/6 * SJL	abnormal bone marrow morphology	J:129327
	abnormal cartilage morphology	J:129327
	abnormal chondrocyte morphology	J:129327
	abnormal craniofacial bone morphology	J:129327
	abnormal pubis morphology	J:129327
	axial skeleton hypoplasia	J:129327
	decreased body weight	J:129327
	decreased chondrocyte proliferation	J:129327
	decreased locomotor activity	J:129327
	delayed endochondral bone ossification	J:129327
	disorganized long bone epiphyseal plate	J:129327
	disproportionate dwarf	J:129327
	domed cranium	J:129327
	increased width of hypertrophic chondrocyte zone	J:129327
	kyphosis	J:129327
	long incisors	J:129327
	short limbs	J:129327
	short lumbar vertebrae	J:129327
	short nasal bone	J:129327
	small frontal bone	J:129327
	small occipital bone	J:129327
Wnt4^tm1.1Bhr/Wnt4^tm1.1Bhr Tg(Prrx1-cre)1Cjt/0 involves: 129S7/SvEvBrd * C57BL/6J	decreased areal bone mineral density	J:293133
	decreased bone mineral density of femur	J:293133
	decreased bone trabecula number	J:293133
	decreased femoral compact bone area	J:293133
	decreased trabecular bone mass	J:293133
Wnt4^tm1.1Boer/Wnt4^tm1.1Boer involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ	no abnormal phenotype detected	J:162337
Wnt4^tm1.1Svo/Wnt4^tm1.1Svo involves: 129/Sv * C57BL/6	no abnormal phenotype detected	J:154784
Wnt4^tm1.1Svo/Wnt4^tm1.1Svo Tg(CAG-cre)13Miya/0 involves: 129/Sv * C57BL/6	abnormal kidney development	J:154784
Wnt4^tm1.2Bhr/Wnt4^tm1.2Bhr involves: 129S4/SvJaeSor * 129S7/SvEvBrd * C57BL/6J	neonatal lethality, complete penetrance	J:171430
Wnt4^tm1.2Boer/Wnt4^tm1.2Boer involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ	abnormal kidney development	J:162337
	abnormal reproductive system development	J:162337
	postnatal lethality, complete penetrance	J:162337
Wnt4^tm1Amc/Wnt4^tm1Amc involves: 129/Sv * C57BL/6	decreased renal glomerulus number	J:98831
Wnt4^tm1Amc/Wnt4^tm1Amc involves: 129/Sv * C57BL/6	small metanephros	J:98831
Wnt4^tm1Amc/Wnt4^tm1Amc involves: 129/Sv * CD-1	abnormal adenohypophysis morphology	J:48144
	abnormal adrenal gland physiology	J:80420
	decreased gonadotroph cell number	J:48144
	decreased somatotroph cell number	J:48144
	decreased thyrotroph cell number	J:48144
Wnt4^tm1Amc/Wnt4^tm1Amc involves: 129S1/Sv	abnormal female germ cell morphology	J:52554
	abnormal metanephric mesenchyme morphology	J:21884
	abnormal nephrogenic mesenchyme morphogenesis	J:21884
	abnormal oogenesis	J:52554
	abnormal ovary morphology	J:52554
	abnormal secondary sex determination	J:52554
	absent kidney	J:21884
	absent Mullerian ducts	J:52554
	decreased oocyte number	J:52554
	decreased thymocyte number	J:75999
	delayed kidney development	J:21884
	kidney failure	J:21884
	neonatal lethality, complete penetrance	J:21884
	normal nervous system phenotype	J:155074
	oocyte degeneration	J:52554
	secondary sex reversal	J:52554
Wnt4^tm1Amc/Wnt4^{tm3(EGFP/cre)Amc} involves: 129S1/Sv * C57BL/6J	abnormal oogenesis	J:203797
	decreased oocyte number	J:203797
Wnt4^{tm2(EGFP/cre)Svo}/Wnt4^tm1Svo involves: 129/Sv * C57BL/6	abnormal kidney development	J:154784
	abnormal kidney mesenchyme morphology	J:154784
	abnormal ovary development	J:154784
	absent kidney	J:154784
	absent ovary capsule	J:154784
	primary sex reversal	J:154784
	small kidney	J:154784
Wnt4^{tm2(EGFP/cre/ERT2)Amc}/Wnt4⁺ involves: 129/Sv * 129S/SvEv * C57BL/6 * C57BL/6J	atrioventricular cushion hypoplasia	J:338879
	normal cardiovascular system phenotype	J:338879
	lethality during fetal growth through weaning, incomplete penetrance	J:338879

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