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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Wt1
WT1 transcription factor
MGI:98968
99 phenotypes from 15 alleles in 22 genetic backgrounds
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Allelic Composition
Genetic Background		 Annotated Term Reference
\Plekha5Tg(AMH-cre)1Flor/\Plekha5+
\Wt1tm1Jae/\Wt1tm2Vih
involves: 129S4/SvJae * 129S7/SvEvBrd * C57BL/6 * SJL 		abnormal Leydig cell morphology J:111787
abnormal male reproductive system morphology J:111787
abnormal secondary sex determination J:111787
abnormal seminiferous tubule morphology J:111787
abnormal Sertoli cell development J:111787
abnormal testis morphology J:111787
male infertility J:111787
small testis J:111787
\Wt1tm1.1Ceng/\Wt1tm1.1Ceng
\Tg(tetO-cre)LC1Bjd/0
\Tg(NPHS2-rtTA2*M2)1Jbk/0
involves: BALB/c * C57BL/6 * FVB/N 		albuminuria J:197989
glomerulosclerosis J:197989
\Wt1tm1.1Jak/\Wt1tm1.1Jak
involves: 129S4/SvJae 		no abnormal phenotype detected J:76780
\Wt1tm1.1Lahe/\Wt1+
involves: 129S2/SvPas * C57BL/6 * FVB/NCrl * SJL 		abnormal glomerular capsule parietal layer morphology J:154995
abnormal mesangial cell morphology J:154995
abnormal podocyte morphology J:154995
abnormal renal glomerulus morphology J:154995
expanded mesangial matrix J:154995
glomerulosclerosis J:154995
increased renal glomerulus basement membrane thickness J:154995
increased urine protein level J:154995
mesangiolysis J:154995
podocyte hypertrophy J:154995
premature death J:154995
\Wt1tm1.1Lahe/\Wt1+
involves: 129S2/SvPas * C57BL/6 * SJL 		normal renal/urinary system phenotype J:154995
\Wt1tm1.1Ndha/\Wt1tm1.1Ndha
\Tg(Gata4*G2-cre)#Roja/0
involves: 129P2/OlaHsd 		abnormal coronary vessel morphology J:229936
abnormal diaphragm development J:238024
abnormal intermediate mesoderm morphology J:238024
abnormal mesenchyme morphology J:238024
abnormal pleural cavity morphology J:238024
diaphragmatic hernia J:238024
lethality throughout fetal growth and development, incomplete penetrance J:229936, J:238024
thin ventricle myocardium compact layer J:229936
\Wt1tm1.1Ndha/\Wt1tm1.1Ndha
\Tg(Tek-cre/ERT2)1Arnd/0
involves: 129P2/OlaHsd * C57BL/6 * DBA/2 		abnormal coronary vessel morphology J:229936
\Wt1tm1.1Ndha/\Wt1tm1Nhsn
\Tg(GATA5-cre)1Krc/0
involves: 129P2/OlaHsd * 129S2/SvPas 		abnormal cardiovascular system physiology J:166573
abnormal heart right ventricle morphology J:166573
edema J:166573
hemopericardium J:166573
lethality throughout fetal growth and development, complete penetrance J:166573
poor circulation J:166573
\Wt1tm1Asc/\Wt1+
involves: 129S7/SvEvBrd * C57BL/6 		abnormal renal glomerulus morphology J:71149
decreased germ cell number J:71149
neonatal lethality, complete penetrance J:71149
primary sex reversal J:71149
small kidney J:71149
\Wt1tm1Asc/\Wt1tm1Asc
involves: 129S7/SvEvBrd * C57BL/6J 		abnormal renal glomerulus morphology J:71149
decreased germ cell number J:71149
neonatal lethality, complete penetrance J:71149
primary sex reversal J:71149
small kidney J:71149
\Wt1tm1Hst/\Wt1tm1Hst
involves: 129P2/OlaHsd * C57BL/6 * CD-1 		no abnormal phenotype detected J:82515
\Wt1tm1Jae/\Wt1tm1Jae
involves: 129S4/SvJae 		abnormal diaphragm development J:238024
abnormal mesenchyme morphology J:238024
\Wt1tm1Jae/\Wt1tm1Jae
involves: 129S4/SvJae * BALB/c * C57BL/6 		neonatal lethality, complete penetrance J:56651
primary atelectasis J:56651
\Wt1tm1Jae/\Wt1tm1Jae
involves: 129S4/SvJae * C3H * C57BL/6 		neonatal lethality, complete penetrance J:56651
primary atelectasis J:56651
\Wt1tm1Jae/\Wt1tm1Jae
involves: 129S4/SvJae * C57BL/6 		abnormal embryonic tissue morphology J:14317
abnormal gonadal ridge morphology J:14317
abnormal heart apex morphology J:14317
abnormal kidney development J:14317
abnormal lung development J:14317
normal cardiovascular system phenotype J:14317
diaphragmatic hernia J:14317
edema J:14317
hemopericardium J:14317
increased metanephric mesenchyme apoptosis J:14317
lethality throughout fetal growth and development, complete penetrance J:14317
small heart J:14317
\Wt1tm1Jae/\Wt1tm1Jae
involves: 129S4/SvJae * C57BL/6 * MF1 		abnormal diaphragm development J:114565
abnormal spleen development J:56651
absent adrenal gland J:56651
absent spleen J:56651
diaphragmatic hernia J:114565
increased splenocyte apoptosis J:56651
perinatal lethality, complete penetrance J:56651
prenatal lethality, incomplete penetrance J:56651
pulmonary hypoplasia J:114565
\Wt1tm1Jae/\Wt1tm1Jae
involves: 129S4/SvJae * NMRI 		abnormal pleuropericardial membrane morphology J:192889
\Wt1tm1Jak/\Wt1tm1Jak
involves: 129S4/SvJae 		embryonic lethality, complete penetrance J:76780
\Wt1tm1Mlh/\Wt1+
129P2/OlaHsd-Wt1tm1Mlh 		abnormal mesangial cell morphology J:135449
expanded mesangial matrix J:135449
glomerulonephritis J:135449
glomerulosclerosis J:135449
increased mesangial cell number J:135449
increased urine protein level J:135449
juxtaglomerular cell hyperplasia J:135449
kidney cortex cyst J:135449
podocyte hypertrophy J:135449
renal cast J:135449
\Wt1tm1Mlh/\Wt1+
involves: 129P2/OlaHsd * C57BL/6 		abnormal mesangial cell morphology J:135449
expanded mesangial matrix J:135449
glomerulonephritis J:135449
glomerulosclerosis J:135449
increased mesangial cell number J:135449
increased urine protein level J:135449
juxtaglomerular cell hyperplasia J:135449
kidney cortex cyst J:135449
podocyte hypertrophy J:135449
renal cast J:135449
\Wt1tm1Mlh/\Wt1+
involves: 129P2/OlaHsd * C57BL/6 * MF1 		abnormal mesangial cell morphology J:135449
expanded mesangial matrix J:135449
glomerulonephritis J:135449
glomerulosclerosis J:135449
increased mesangial cell number J:135449
increased urine protein level J:135449
juxtaglomerular cell hyperplasia J:135449
kidney cortex cyst J:135449
podocyte hypertrophy J:135449
renal cast J:135449
\Wt1tm1Mlh/\Wt1tm1Mlh
involves: 129P2/OlaHsd * C57BL/6 		abnormal adrenal gland development J:135449
abnormal diaphragm development J:135449
abnormal heart apex morphology J:135449
abnormal heart development J:135449
abnormal heart shape J:135449
abnormal kidney development J:135449
abnormal liver development J:135449
absent metanephros J:135449
absent ovary J:135449
absent testes J:135449
agonadal J:135449
decreased embryo size J:135449
embryonic lethality during organogenesis, incomplete penetrance J:135449
hemopericardium J:135449
lethality throughout fetal growth and development, complete penetrance J:135449
liver hypoplasia J:135449
myocardium hypoplasia J:135449
\Wt1tm1Nhsn/\Wt1+
involves: 129S2/SvPas * C57BL/6 		no abnormal phenotype detected J:123972
\Wt1tm1Nhsn/\Wt1tm1Nhsn
involves: 129S2/SvPas * C57BL/6 		perinatal lethality, complete penetrance J:123972
\Wt1tm1Vih/\Wt1+
involves: 129S7/SvEvBrd * C57BL/6 		abnormal granulosa cell morphology J:204518
abnormal primary ovarian follicle morphology J:204518
decreased ovulation rate J:204518
decreased superovulation rate J:204518
impaired granulosa cell differentiation J:204518
impaired ovarian folliculogenesis J:204518
reduced female fertility J:204518
normal renal/urinary system phenotype J:94225
small ovary J:204518
\Wt1tm1Vih/\Wt1+
involves: 129S7/SvEvBrd * C57BL/6 * MF1 		glomerulosclerosis J:94225
increased urine protein level J:94225
podocyte foot process effacement J:94225
premature death J:94225
\Wt1tm1Vih/\Wt1tm1Vih
involves: 129S7/SvEvBrd * C57BL/6 		prenatal lethality J:94225
\Wt1tm2.1Vih/\Wt1+
involves: 129S7/SvEvBrd * C57BL/6 		no abnormal phenotype detected J:111787
\Wt1tm2.1Vih/\Wt1tm2.1Vih
involves: 129S7/SvEvBrd * C57BL/6 		lethality throughout fetal growth and development, complete penetrance J:111787
\Wt1tm2Asc/\Wt1tm2Asc
involves: 129S7/SvEvBrd * C57BL/6J 		abnormal renal glomerulus morphology J:71149
abnormal secondary sex determination J:71149
neonatal lethality, complete penetrance J:71149
small kidney J:71149
streak gonad J:71149
\Wt1tm2Hst/\Wt1+
chimera involves: 129P2/OlaHsd * C57BL/6JLac * CBA/CaLac 		abnormal glomerular capillary morphology J:53585
abnormal kidney interlobular artery morphology J:53585
abnormal kidney vasculature morphology J:53585
abnormal mesangial cell morphology J:53585
abnormal reproductive system physiology J:103489
absent podocyte foot process J:53585
azoospermia J:103489
decreased glomerular capsule space J:53585
dilated renal tubule J:53585
expanded mesangial matrix J:53585
glomerular crescent J:53585
glomerulosclerosis J:53585
increased mesangial cell number J:53585
kidney cyst J:53585
kidney failure J:53585
male infertility J:53585
podocyte hypertrophy J:53585
podocyte microvillus transformation J:53585
renal interstitial fibrosis J:53585
small testis J:53585, J:103489
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Send questions and comments to User Support. 		last database update
03/25/2025
MGI 6.24 		The Jackson Laboratory