Xbp1 Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Xbp1
X-box binding protein 1
MGI:98970

83 phenotypes from 10 alleles in 14 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Tg(tetO-Xbp1_is)#Pesch/0 Tg(Adipoq-rtTA)2Zvw/0 involves: C57BL/6 * C57BL/6N * FVB/N	abnormal nucleotide metabolism	J:260830
	abnormal white adipose tissue morphology	J:260830
	decreased body fat mass	J:260830
	decreased body temperature	J:260830
	decreased brown adipose tissue mass	J:260830
	decreased fat cell size	J:260830
	decreased susceptibility to diet-induced obesity	J:260830
	decreased white adipose tissue mass	J:260830
	increased basal metabolism	J:260830
	increased carbon dioxide production	J:260830
	increased fatty acid oxidation	J:260830
	increased oxygen consumption	J:260830
	weight loss	J:260830
Xbp1^tm1.1Geno/Xbp1^tm1.1Geno Tg(Tek-cre)1Ywa/0 involves: 129S2/SvPas * C57BL/6 * SJL	abnormal blood flow velocity	J:211440
	abnormal physiological neovascularization	J:211440
	abnormal response to injury	J:211440
	abnormal retina blood vessel morphology	J:211440
	decreased angiogenesis	J:211440
Xbp1^tm1.2Geno/Xbp1^tm1.2Geno involves: 129S2/SvPas * C57BL/6	abnormal blood vessel morphology	J:211440
	decreased cell proliferation	J:211440
	decreased embryo weight	J:211440
	embryonic growth retardation	J:211440
	embryonic lethality during organogenesis, complete penetrance	J:211440
	pallor	J:211440
Xbp1^{tm1a(EUCOMM)Wtsi}/Xbp1⁺ C57BL/6N-Xbp1^{tm1a(EUCOMM)Wtsi}/Ics	abnormal bone mineralization	J:165965
	abnormal bone structure	J:165965
	decreased circulating cholesterol level	J:165965
	decreased circulating triglyceride level	J:165965
	decreased IgG1 level	J:165965
	decreased T cell number	J:165965
	increased grip strength	J:165965
	vertebral fusion	J:165965
Xbp1^{tm1b(EUCOMM)Wtsi}/Xbp1⁺ C57BL/6N-Xbp1^{tm1b(EUCOMM)Wtsi}/Ics	decreased large unstained cell number	J:211773
	decreased leukocyte cell number	J:211773
	decreased lymphocyte cell number	J:211773
	decreased red blood cell distribution width	J:211773
	increased mean corpuscular hemoglobin	J:211773
	increased mean corpuscular volume	J:211773
	persistence of hyaloid vascular system	J:211773
Xbp1^{tm1b(EUCOMM)Wtsi}/Xbp1^{tm1b(EUCOMM)Wtsi} C57BL/6N-Xbp1^{tm1b(EUCOMM)Wtsi}/Ics	preweaning lethality, complete penetrance	J:211773
Xbp1^tm1Glm/Xbp1^tm1Glm involves: 129S2/SvPas	abnormal liver development	J:59916
	anemia	J:59916
	decreased hepatocyte proliferation	J:59916
	embryonic growth retardation	J:59916
	embryonic lethality during organogenesis, complete penetrance	J:59916
	impaired hematopoiesis	J:59916
	increased hepatocyte apoptosis	J:59916
	liver hypoplasia	J:59916
	pallor	J:59916
	small liver	J:59916
Xbp1^tm1Nogu/Xbp1^tm1Nogu involves: 129S/SvEv * A/J	abnormal heart development	J:56678
	absent trabeculae carneae	J:56678
	anoxia	J:56678
	embryo tissue necrosis	J:56678
	embryonic growth retardation	J:56678
	embryonic lethality during organogenesis, complete penetrance	J:56678
	enlarged pericardium	J:56678
	myocardium necrosis	J:56678
	thin ventricular wall	J:56678
	wavy neural tube	J:56678
Xbp1^tm1Tiw/Xbp1^tm1Tiw involves: 129S4/SvJae * C57BL/6	abnormal extraembryonic tissue physiology	J:153222
Xbp1^tm1Tiw/Xbp1^tm1Tiw involves: 129S4/SvJae * C57BL/6	decreased embryo size	J:153222
Xbp1^tm2Glm/Xbp1⁺ Tg(Vil1-cre)997Gum/0 involves: 129S6/SvEvTac * C57BL/6J * FVB/N * SJL	small intestinal inflammation	J:188627
Xbp1^tm2Glm/Xbp1^tm2Glm Tg(Adipoq-rtTA)2Zvw/0 Tg(tetO-cre)1Jaw/0 involves: 129 * 129S6/SvEvTac * C57BL/6 * C57BL/6N	abnormal nucleotide metabolism	J:260830
	increased body fat mass	J:260830
Xbp1^tm2Glm/Xbp1^tm2Glm Tg(Defa6-icre)1Rsb/0 involves: 129S6/SvEvTac * C57BL/6	abnormal autophagy	J:206084
	abnormal Paneth cell morphology	J:206084
	small intestinal inflammation	J:206084
Xbp1^tm2Glm/Xbp1^tm2Glm Tg(Mx1-cre)1Cgn/0 involves: 129S6/SvEvTac * C57BL/6 * CBA	abnormal lipid homeostasis	J:137188
	decreased cholesterol level	J:137188
	decreased circulating triglyceride level	J:137188
	decreased fatty acids level	J:137188
Xbp1^tm2Glm/Xbp1^tm2Glm Tg(Nes-cre)1Kln/0 involves: 129S6/SvEvTac * C57BL/6 * SJL	normal behavior/neurological phenotype	J:131028
	decreased susceptibility to prion infection	J:131028
	normal mortality/aging	J:131028
	normal nervous system phenotype	J:131028
Xbp1^tm2Glm/Xbp1^tm2Glm Tg(Vil1-cre)997Gum/0 involves: 129S6/SvEvTac * C57BL/6 * SJL	abnormal autophagy	J:206084
	abnormal enterocyte physiology	J:206084
	small intestinal inflammation	J:206084
Xbp1^tm2Glm/Xbp1^tm2Glm Tg(Vil1-cre)997Gum/0 involves: 129S6/SvEvTac * C57BL/6J * FVB/N * SJL	abnormal cell migration	J:188627
	abnormal endoplasmic reticulum morphology	J:188627
	abnormal intestine physiology	J:188627
	abnormal small intestine goblet cell morphology	J:188627
	absent Paneth cells	J:188627
	cachexia	J:188627
	crypts of Lieberkuhn abscesses	J:188627
	increased susceptibility to bacterial infection	J:188627
	increased susceptibility to induced colitis	J:188627
	intestinal ulcer	J:188627
	rectal hemorrhage	J:188627
	small intestinal inflammation	J:188627
Xbp1^tm2Glm/Xbp1^tm2Glm Tg(Vil1-cre/ERT2)23Syr/0 involves: 129S6/SvEvTac * C57BL/6 * DBA/2	abnormal autophagy	J:206084
	abnormal enterocyte physiology	J:206084
	small intestinal inflammation	J:206084
Xbp1^tm3Glm/Xbp1^tm3Glm Tg(Vil1-cre/ERT2)23Syr/0 involves: 129S6/SvEvTac * C57BL/6 * DBA/2	abnormal intestine physiology	J:188627
	decreased Paneth cell number	J:188627
	decreased small intestinal villus size	J:188627
	increased apoptosis	J:188627
	small intestinal inflammation	J:188627

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