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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Xdh
xanthine dehydrogenase
MGI:98973
52 phenotypes from 6 alleles in 5 genetic backgrounds
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Allelic Composition
Genetic Background		 Annotated Term Reference
Xdhem1(IMPC)Mbp/Xdh+
C57BL/6N-Xdhem1(IMPC)Mbp/MbpMmucd 		abnormal lung morphology J:211773
abnormal skin morphology J:211773
abnormal vitreous body morphology J:211773
cataract J:211773
persistence of hyaloid vascular system J:211773
Xdhem1(IMPC)Mbp/Xdhem1(IMPC)Mbp
C57BL/6N-Xdhem1(IMPC)Mbp/MbpMmucd 		male infertility J:211773
Xdhrenf/Xdhrenf
involves: C3H * C57BL/6J 		abnormal kidney cortex morphology J:187066
abnormal renal tubule epithelium morphology J:187066
abnormal renal tubule morphology J:187066
decreased blood uric acid level J:187066
dilated renal tubule J:187066
increased activity of parathyroid J:187066
increased blood urea nitrogen level J:187066
increased circulating alkaline phosphatase level J:187066
increased circulating calcium level J:187066
increased circulating creatinine level J:187066
premature death J:187066
renal interstitial fibrosis J:187066
slow postnatal weight gain J:187066
small kidney J:187066
Xdhtm1.1Takni/Xdhtm1.1Takni
involves: C57BL/6 		abnormal peritoneal macrophage morphology J:281671
normal growth/size/body region phenotype J:281671
normal hematopoietic system phenotype J:281671
normal mortality/aging J:281671
oxidative stress J:281671
Xdhtm1Fink/Xdhtm1Fink
involves: 129X1/SvJ * C57BL/6J 		abnormal kidney development J:103558
abnormal kidney morphology J:103558, J:166326
abnormal lipid homeostasis J:166326
abnormal renal glomerulus morphology J:103558
abnormal renal tubule epithelium morphology J:166326
abnormal renal tubule morphology J:166326
crystalluria J:166326
decreased abdominal adipose tissue amount J:166326
decreased blood uric acid level J:103558
decreased body size J:166326
dilated renal tubule J:103558, J:166326
normal homeostasis/metabolism phenotype J:103558
hypoxia J:166326
increased blood urea nitrogen level J:103558
increased circulating amylase level J:103558
increased circulating hypoxanthine level J:166326
increased circulating xanthine level J:166326
increased triglyceride level J:166326
increased urine hypoxanthine level J:166326
increased urine xanthine level J:166326
kidney failure J:166326
oxidative stress J:166326
pale kidney J:103558, J:166326
postnatal lethality, complete penetrance J:103558
premature death J:166326
renal interstitial fibrosis J:166326
slow postnatal weight gain J:103558
small kidney J:103558
tubulointerstitial nephritis J:166326
Xdhtm1Mrc/Xdh+
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 		abnormal involution of the mammary gland J:80993
abnormal lactation J:80993
abnormal mammary gland growth during lactation J:80993
abnormal milk composition J:80993
abnormal skeletal muscle morphology J:80993
decreased body weight J:80993
decreased total body fat amount J:80993
Xdhtm1Mrc/Xdhtm1Mrc
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 		decreased body size J:80993
premature death J:80993
Xdhtm2.1Takni/Xdhtm2.1Takni
involves: C57BL/6 		normal cellular phenotype J:281671
normal growth/size/body region phenotype J:281671
normal hematopoietic system phenotype J:281671
normal mortality/aging J:281671
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory