Xpa Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Xpa
xeroderma pigmentosum, complementation group A
MGI:99135

42 phenotypes from 3 alleles in 6 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Xpa^tm1Gvh/Xpa^tm1Hvs involves: 129P2/OlaHsd * C57BL/6J	decreased cellular sensitivity to ultraviolet irradiation	J:179808
Xpa^tm1Gvh/Xpa^tm1Hvs Tg(CAG-cre)13Miya/0 involves: 129P2/OlaHsd * C57BL/6 * C57BL/6J	increased cellular sensitivity to ultraviolet irradiation	J:179808
Xpa^tm1Hvs/Xpa^tm1Hvs involves: 129P2/OlaHsd	abnormal epidermal layer morphology	J:145759
	acanthosis	J:145759
	increased cellular sensitivity to ultraviolet irradiation	J:145759
	reddish skin	J:145759
	scaly skin	J:145759
	skin edema	J:145759
Xpa^tm1Hvs/Xpa^tm1Hvs involves: 129P2/OlaHsd * C57BL/6	abnormal cell physiology	J:112689
	anemia	J:28710
	cornea opacity	J:112689
	embryonic lethality during organogenesis, incomplete penetrance	J:28710
	fetal growth retardation	J:28710
	impaired hematopoiesis	J:28710
	increased incidence of induced tumors	J:28710
	increased incidence of tumors by UV-induction	J:112689
	pallor	J:28710
	small liver	J:28710
Xpa^tm1Hvs/Xpa^tm1Hvs involves: 129P2/OlaHsd * C57BL/6J	increased cellular sensitivity to ultraviolet irradiation	J:122013
Xpa^tm1Tnka/Xpa^tm1Tnka C3.Cg-Xpa^tm1Tnka	increased liver adenoma incidence	J:76206
Xpa^tm1Tnka/Xpa^tm1Tnka C3.Cg-Xpa^tm1Tnka	increased liver tumor incidence	J:76206
Xpa^tm1Tnka/Xpa^tm1Tnka involves: C57BL/6 * CBA	abnormal base-excision repair	J:28709
	abnormal epididymis morphology	J:141237
	abnormal immune system physiology	J:35054
	abnormal Langerhans cell physiology	J:35054
	abnormal lymphocyte physiology	J:55739
	abnormal NK cell physiology	J:55739
	abnormal seminiferous tubule epithelium morphology	J:141237
	abnormal spermatogenesis	J:141237
	abnormal testis morphology	J:141237
	decreased body weight	J:141237
	decreased testis weight	J:141237
	increased cellular sensitivity to ultraviolet irradiation	J:28709, J:35054
	increased circulating follicle stimulating hormone level	J:141237
	increased incidence of induced tumors	J:28709
	increased incidence of tumors by chemical induction	J:28709
	increased incidence of tumors by UV-induction	J:28709
	increased Leydig cell number	J:141237
	increased lung adenocarcinoma incidence	J:62877
	increased lung adenoma incidence	J:62877
	increased NK cell number	J:55739
	increased papilloma incidence	J:28709
	increased prostaglandin level	J:60201
	increased skin squamous cell carcinoma incidence	J:28709
	increased tumor incidence	J:141237
	reduced male fertility	J:141237
	seminiferous tubule degeneration	J:141237

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/10/2024 MGI 6.24