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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Yy1
YY1 transcription factor
MGI:99150
70 phenotypes from 4 alleles in 8 genetic backgrounds
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Allelic Composition
Genetic Background		 Annotated Term Reference
Tg(Zp3-cre)93Knw/0
Yy1tm1Yshi/Yy1tm2.1Yshi
involves: 129S4/SvJae * C57BL/6J 		abnormal circulating hormone level J:170240
abnormal oocyte morphology J:170240
abnormal ovary physiology J:170240
abnormal secondary ovarian follicle morphology J:170240
absent estrous cycle J:170240
absent mature ovarian follicles J:170240
absent tertiary ovarian follicles J:170240
decreased copulatory plug deposition J:170240
decreased secondary ovarian follicle number J:170240
female infertility J:170240
impaired ovarian folliculogenesis J:170240
increased circulating follicle stimulating hormone level J:170240
increased primary ovarian follicle number J:170240
oocyte degeneration J:170240
small ovary J:170240
Yy1tm1Yshi/Yy1+
involves: 129S4/SvJae * C57BL/6 		decreased embryo size J:57857
exencephaly J:57857
Yy1tm1Yshi/Yy1tm1Yshi
either: (involves: 129S4/SvJae) or (involves: 129S4/SvJae * C57BL/6) 		absent egg cylinders J:57857
embryonic lethality, complete penetrance J:57857
Yy1tm1Yshi/Yy1tm2.1Yshi
Edil3Tg(Sox2-cre)1Amc/Edil3+
involves: 129S4/SvJae * C57BL/6 * CBA 		abnormal endoderm development J:186556
abnormal extraembryonic ectoderm morphology J:186556
abnormal extraembryonic tissue morphology J:186556
abnormal gastrulation J:186556
abnormal gastrulation movements J:186556
abnormal mesoderm development J:186556
abnormal primitive streak elongation J:186556
abnormal primitive streak formation J:186556
abnormal rostral-caudal axis patterning J:186556
abnormal visceral endoderm morphology J:186556
absent head fold J:186556
absent notochord J:186556
absent primitive node J:186556
decreased embryo size J:186556
Yy1tm1Yshi/Yy1tm2Yshi
involves: 129S4/SvJae 		cyanosis J:108369
decreased cell proliferation J:108369
lethality throughout fetal growth and development, incomplete penetrance J:108369
neonatal lethality, complete penetrance J:108369
pallor J:108369
respiratory failure J:108369
Yy1tm2.1Yshi/Yy1tm2.1Yshi
involves: 129S4/SvJae 		no abnormal phenotype detected J:108369
Yy1tm2.1Yshi/Yy1tm2.1Yshi
Shhtm1(EGFP/cre)Cjt/Shh+
involves: 129S4/SvJae * C57BL/6J 		abnormal airway basal cell morphology J:239777
abnormal branching involved in lung morphogenesis J:239777
abnormal lung development J:239777
abnormal lung epithelium morphology J:239777
abnormal lung morphology J:239777
abnormal lung-associated mesenchyme development J:239777
abnormal respiratory epithelium physiology J:239777
abnormal trachea morphology J:239777
abnormal tracheal cartilage morphology J:239777
abnormal tracheal ciliated epithelium morphology J:239777
decreased club cell number J:239777
decreased respiratory mucosa goblet cell number J:239777
impaired myofibroblast differentiation J:239777
increased lung apoptosis J:239777
left pulmonary isomerism J:239777
lung cyst J:239777
neonatal lethality, complete penetrance J:239777
respiratory failure J:239777
trachea stenosis J:239777
Yy1tm2.1Yshi/Yy1tm2.1Yshi
Tg(Dct-lacZ)A12Jkn/0
Tg(Tyr-cre)1Lru/Y
involves: 129S4/SvJae * C57BL/6 * CBA * DBA/2 		abnormal hair follicle melanocyte morphology J:185128
abnormal melanoblast morphology J:185128
absent hair follicle melanin granules J:185128
decreased melanocyte number J:185128
Yy1tm2.1Yshi/Yy1tm2.1Yshi
Tg(Nkx2-1-cre)2Sand/0
involves: 129S4/SvJae * C57BL/6J 		abnormal respiratory epithelium physiology J:239777
increased blastoma incidence J:239777
lethality at weaning, complete penetrance J:239777
lung cyst J:239777
neonatal lethality, incomplete penetrance J:239777
Yy1tm2.1Yshi/Yy1tm2.1Yshi
Tg(Tyr-cre)1Lru/Y
involves: 129S4/SvJae * C57BL/6 * DBA/2 		abnormal coat/hair pigmentation J:185128
abnormal dorsoventral coat patterning J:185128
abnormal hair follicle melanin granule morphology J:185128
abnormal hair follicle melanocyte morphology J:185128
absent hair follicle melanin granules J:185128
decreased melanocyte number J:185128
decreased skin pigmentation J:185128
Yy1tm2Yshi/Yy1tm2Yshi
involves: 129S4/SvJae 		decreased birth body size J:108369
prenatal lethality, incomplete penetrance J:108369
Yy1tm3.1Yshi/Yy1+
involves: 129P2/OlaHsd * 129S4/SvJaeSor * C57BL/6J 		normal immune system phenotype J:208226
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory