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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Fasl
Fas ligand
MGI:99255
94 phenotypes from 12 alleles in 18 genetic backgrounds
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Allelic Composition
Genetic Background		 Annotated Term Reference
Fasldel1Hong/Fasldel1Hong
either: (involves: 129 * BALB/c * C57BL/6) or (involves: 129X1/SvJ * C3H/HeJ * C57BL/6) 		abnormal definitive hematopoiesis J:112563
abnormal thymus cell ratio J:112563
enlarged lymph nodes J:112563
enlarged spleen J:112563
enlarged thymus J:112563
increased IgG level J:112563
increased IgM level J:112563
increased lymphoma incidence J:112563
increased metastatic potential J:112563
premature death J:112563
Faslgld/Faslgld
B6.C3-Faslgld 		abnormal lymph node morphology J:91058
normal cardiovascular system phenotype J:91058
enlarged lymph nodes J:91058
enlarged spleen J:91058
normal homeostasis/metabolism phenotype J:91058
impaired macrophage phagocytosis J:91058
increased anti-nuclear antigen antibody level J:91058
increased apoptosis J:91058
increased autoantibody level J:91058
increased spleen weight J:91058
Faslgld/Faslgld
B6Smn.C3-Faslgld/J 		abnormal eye electrophysiology J:136745
abnormal hepatocyte morphology J:135830
abnormal male germ cell apoptosis J:146994
abnormal NK cell physiology J:115033
abnormal osteoclast physiology J:127179
brain inflammation J:120427
CNS inflammation J:120427
decreased circulating alanine transaminase level J:135830
decreased granulocyte number J:136745
decreased hepatocyte apoptosis J:135830
demyelination J:120427
eye inflammation J:136745
focal hepatic necrosis J:135830
increased sperm number J:146994
increased susceptibility to bacterial infection J:136745
increased susceptibility to Picornaviridae infection J:120427
liver inflammation J:135830
Faslgld/Faslgld
C3H/HeJ-Faslgld 		abnormal interleukin level J:8267
abnormal T cell morphology J:8267
abnormal T cell physiology J:8267
abnormal T cell proliferation J:8267
decreased neuron apoptosis J:124252
Faslgld/Faslgld
C3H/HeJ-Faslgld/J 		abnormal lymph node morphology J:7306
abnormal T cell differentiation J:8267, J:12002
anemia J:7306
normal cardiovascular system phenotype J:7306
decreased B cell number J:29572
decreased cytotoxic T cell cytolysis J:17698
enlarged lymph nodes J:7306, J:29572
enlarged spleen J:7306, J:29572
increased anti-double stranded DNA antibody level J:7306
increased anti-nuclear antigen antibody level J:7306, J:29572
increased autoantibody level J:7306
increased IgA level J:7306, J:29572
increased IgG1 level J:7306
increased IgG2a level J:7306
increased IgG2b level J:7306
increased IgG level J:29572
increased IgM level J:7306, J:29572
increased immunoglobulin level J:7306, J:29572
increased leukocyte cell number J:7306
increased lymphocyte cell number J:7306, J:29572
increased neutrophil cell number J:7306
increased T cell number J:29572
interstitial pneumonia J:7306
normal mortality/aging J:120650
normal neoplasm J:108303
premature death J:7306, J:29572
normal renal/urinary system phenotype J:7306
skin edema J:7306
Faslgld/Faslgld
involves: C3H/HeJ 		abnormal osteoclast physiology J:156947
enlarged lymph nodes J:171440
enlarged spleen J:171440
increased spleen weight J:171440
Faslgld/Faslgld
involves: C3H/HeJ * C57BL/6 		decreased susceptibility to injury J:76811
dermatitis J:153501
enlarged lymph nodes J:153501
enlarged spleen J:153501
normal immune system phenotype J:153501
increased anti-nuclear antigen antibody level J:153501
increased circulating tumor necrosis factor level J:153501
increased histiocytic sarcoma incidence J:153501
increased IgE level J:153501
increased IgG1 level J:153501
increased IgG2a level J:153501
increased IgG2b level J:153501
increased IgG level J:153501
increased susceptibility to systemic lupus erythematosus J:153501
increased T cell number J:153501
premature death J:153501
Faslgld/Faslgld
involves: C3H/HeJ * CBA 		normal reproductive system phenotype J:114219
Faslm1Btlr/Faslm1Btlr
C57BL/6J-Faslm1Btlr 		abnormal humoral immune response J:212067
Faslm2Btlr/Faslm2Btlr
C57BL/6J-Faslm2Btlr 		decreased IgG level J:224659
impaired humoral immune response J:224659
Fasltm1.1Ast/Fasltm1.1Ast
involves: BALB/cJ * C57BL/6 		decreased cytotoxic T cell cytolysis J:153501
dermatitis J:153501
enlarged lymph nodes J:153501
enlarged spleen J:153501
glomerular crescent J:153501
glomerulonephritis J:153501
normal immune system phenotype J:153501
increased anti-double stranded DNA antibody level J:153501
increased anti-nuclear antigen antibody level J:153501
increased circulating tumor necrosis factor level J:153501
increased histiocytic sarcoma incidence J:153501
increased IgA level J:153501
increased IgE level J:153501
increased IgG1 level J:153501
increased IgG2a level J:153501
increased IgG2b level J:153501
increased IgG level J:153501
increased IgM level J:153501
increased immunoglobulin level J:153501
increased liver tumor incidence J:153501
increased susceptibility to systemic lupus erythematosus J:153501
premature death J:153501
renal cast J:153501
Fasltm1.1Bksa/Fasltm1.1Bksa
involves: 129 		abnormal retina ganglion cell morphology J:171440
enlarged lymph nodes J:171440
enlarged spleen J:171440
increased spleen weight J:171440
Fasltm1.1Cgm/Fasltm1.1Cgm
involves: 129S2/SvPas * C57BL/6 * C57BL/6N 		normal immune system phenotype J:168406
increased B cell proliferation J:168406
increased germinal center B cell number J:168406
increased IgM level J:168406
increased plasma cell number J:168406
increased T cell proliferation J:168406
Fasltm1.1Lest/Fasltm1.1Lest
B6.129-Fasltm1.1Lest 		glomerulonephritis J:87990
increased urine protein level J:87990
Fasltm1.1Lest/Fasltm1.1Lest
involves: 129 * C57BL/6 		abnormal double-negative T cell morphology J:87990
abnormal lymph node morphology J:87990
abnormal salivary gland morphology J:87990
autoimmune response J:87990
enlarged liver J:87990
enlarged lymph nodes J:87990
enlarged spleen J:87990
glomerulonephritis J:87990
increased IgG level J:87990
increased urine protein level J:87990
lymphoid hyperplasia J:87990
premature death J:87990
Fasltm1Lest/Fasltm1Lest
involves: 129/Sv * C57BL/6 		no abnormal phenotype detected J:87990
Fasltm2.1Ast/Fasltm2.1Ast
involves: BALB/cJ * C57BL/6 		abnormal cytotoxic T cell physiology J:153501
normal mortality/aging J:153501
Fasltm2.1Bksa/Fasltm2.1Bksa
D2.129-Fasltm2.1Bksa 		abnormal retina nerve fiber layer morphology J:171440
retina ganglion cell degeneration J:171440
normal vision/eye phenotype J:171440
Fasltm2.1Bksa/Fasltm2.1Bksa
involves: 129 * C57BL/6 		abnormal retina nerve fiber layer morphology J:171440
decreased retina ganglion cell number J:171440
increased retina apoptosis J:171440
retina ganglion cell degeneration J:171440
normal vision/eye phenotype J:171440
Tg(Ins2-Fasl)24Ach/0
NOD-Tg(Ins2-Fasl)24Ach/J 		abnormal pancreatic islet morphology J:78679
increased susceptibility to autoimmune diabetes J:78679, J:81416
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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11/12/2024
MGI 6.24 		The Jackson Laboratory