Fasl Phenotype Annotations - Multigenic Genotypes

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Fasl
Fas ligand
MGI:99255

26 phenotypes from multigenic genotypes

Allelic Composition Genetic Background	Annotated Term	Reference
Apoe^tm1Unc/Apoe^tm1Unc Fasl^gld/Fasl^gld B6.Cg-Fasl^gld Apoe^tm1Unc	abnormal lymph node morphology	J:91058
	abnormal renal glomerulus morphology	J:91058, J:200141
	atherosclerotic lesions	J:91058, J:200141
	blood vessel inflammation	J:91058
	decreased circulating HDL cholesterol level	J:91058
	enlarged lymph nodes	J:91058, J:200141
	enlarged spleen	J:91058
	impaired macrophage phagocytosis	J:91058
	increased anti-nuclear antigen antibody level	J:91058, J:200141
	increased apoptosis	J:91058
	increased autoantibody level	J:91058
	increased circulating cholesterol level	J:91058, J:200141
	increased circulating LDL cholesterol level	J:91058
	increased circulating triglyceride level	J:91058
	increased circulating VLDL cholesterol level	J:91058
	increased IgG level	J:91058
	increased spleen weight	J:91058, J:200141
	increased susceptibility to atherosclerosis	J:91058
	increased T cell number	J:91058
	increased urine protein level	J:91058
	kidney inflammation	J:200141
Fas^lpr/Fas^lpr Fasl^tm2.1Bksa/Fasl^tm2.1Bksa involves: 129 * C57BL/6 * MRL/Mp	abnormal retina ganglion cell morphology	J:171440
	normal vision/eye phenotype	J:171440
Fas^lpr/Fas^lpr Tg(Ins2-Fasl)24Ach/0 NOD.Cg-Fas^lpr Tg(Ins2-Fasl)24Ach	decreased susceptibility to autoimmune diabetes	J:81416
Fasl^gld/Fasl^gld Ighm^tm1Cgn/Ighm^tm1Cgn involves: 129S2/SvPas * C3H/HeJ * C57BL/6	normal immune system phenotype	J:119584
Prkdc^scid/Prkdc^scid Tg(Ins2-Fasl)24Ach/0 NOD.Cg-Prkdc^scid Tg(Ins2-Fasl)24Ach	decreased susceptibility to autoimmune diabetes	J:81416
	increased susceptibility to autoimmune diabetes	J:81416
Tg(Ins2-FasI246N)1Ach/0 Tg(Ins2-Fasl)24Ach/0 NOD-Tg(Ins2-FasI246N)1Ach Tg(Ins2-Fasl)24Ach	decreased susceptibility to autoimmune diabetes	J:81416

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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