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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Prkci
protein kinase C, iota
MGI:99260
78 phenotypes from 7 alleles in 9 genetic backgrounds
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Allelic Composition
Genetic Background		 Annotated Term Reference
Prkcitm1.1Rfar/Prkcitm1.1Rfar
involves: 129P2/OlaHsd * BALB/cJ * NMRI 		abnormal cell morphology J:202124
abnormal head fold morphology J:202124
abnormal heart tube morphology J:202124
abnormal mesoderm development J:202124
abnormal proximal-distal axis patterning J:202124
abnormal rostral-caudal axis patterning J:202124
absent allantois J:202124
absent heart tube J:202124
absent somites J:202124
embryonic growth retardation J:202124
embryonic lethality during organogenesis, complete penetrance J:202124
small allantois J:202124
small amniotic cavity J:202124
thick embryonic epiblast J:202124
Prkcitm1Hed/Prkcitm1Hed
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 		abnormal cell morphology J:92719
embryonic lethality, complete penetrance J:92719
Prkcitm1Kido/Prkcitm1.1Kido
Tg(Cryaa-cre)10Mlr/?
involves: FVB/N 		abnormal anterior eye segment morphology J:154910
abnormal iris morphology J:154910
abnormal iris pigment epithelium J:154910
abnormal lens epithelium morphology J:154910
abnormal lens morphology J:154910
disorganized secondary lens fibers J:154910
microphthalmia J:154910
pupil opacity J:154910
small pupil J:154910
Prkcitm1Kido/Prkcitm1.1Kido
Tg(Nphs1-cre)33Mska/0
involves: C57BL/6 * C57BL/6N * DBA/2 		abnormal podocyte morphology J:144995
abnormal podocyte polarity J:144995
abnormal podocyte slit diaphragm morphology J:144995
abnormal podocyte slit junction morphology J:144995
abnormal proximal convoluted tubule morphology J:144995
abnormal renal glomerulus morphology J:144995
decreased podocyte number J:144995
detached podocyte J:144995
dilated glomerular capillary J:144995
expanded mesangial matrix J:144995
fused podocyte foot processes J:144995
glomerulosclerosis J:144995
increased blood urea nitrogen level J:144995
increased circulating creatinine level J:144995
increased urine protein level J:144995
podocyte foot process effacement J:144995
postnatal growth retardation J:144995
premature death J:144995
renal cast J:144995
renal glomerular synechia J:144995
Prkcitm1Kido/Prkcitm1Kido
Tg(Crx-cre)1Tfur/0
Not Specified 		abnormal retina morphology J:102364
abnormal retina photoreceptor morphology J:102364
absent photoreceptor inner segment J:102364
absent photoreceptor outer segment J:102364
hydrocephaly J:102364
microphthalmia J:102364
Prkcitm1Kido/Prkcitm1Kido
Tg(Cryaa-cre)10Mlr/?
involves: FVB/N 		abnormal anterior eye segment morphology J:154910
abnormal iris morphology J:154910
abnormal iris pigment epithelium J:154910
abnormal lens epithelium morphology J:154910
abnormal lens morphology J:154910
disorganized secondary lens fibers J:154910
microphthalmia J:154910
pupil opacity J:154910
small pupil J:154910
Prkcitm1Kido/Prkcitm1Kido
Tg(Ins2-cre)25Mgn/0
involves: 129/Sv * C57BL/6 * DBA/2 		abnormal pancreas secretion J:95378
decreased circulating glucose level J:95378
impaired glucose tolerance J:95378
Prkcitm1Ltg/Prkcitm1Ltg
involves: 129P2/OlaHsd * NMRI 		abnormal head fold morphology J:202124
abnormal heart tube morphology J:202124
abnormal proximal-distal axis patterning J:202124
abnormal rostral-caudal axis patterning J:202124
absent allantois J:202124
absent heart tube J:202124
absent somites J:202124
embryonic growth retardation J:202124
embryonic lethality during organogenesis, complete penetrance J:202124
small allantois J:202124
small amniotic cavity J:202124
thick embryonic epiblast J:202124
Prkcitm1Rfar/Prkci+
Tg(Ckmm-cre)5Khn/?
involves: 129P2/OlaHsd * C57BL/6 * FVB 		abnormal circulating lipid level J:123964
abnormal glucose homeostasis J:123964
decreased adipocyte glucose uptake J:123964
decreased cardiac muscle cell glucose uptake J:123964
decreased circulating HDL cholesterol level J:123964
decreased muscle cell glucose uptake J:123964
decreased skeletal muscle cell glucose uptake J:123964
hepatic steatosis J:123964
impaired glucose tolerance J:123964
increased body weight J:123964
increased circulating cholesterol level J:123964
increased circulating free fatty acids level J:123964
increased circulating glucose level J:123964
increased circulating insulin level J:123964
increased circulating LDL cholesterol level J:123964
increased circulating leptin level J:123964
increased circulating triglyceride level J:123964
increased food intake J:123964
increased susceptibility to autoimmune diabetes J:123964
insulin resistance J:123964
obese J:123964
pancreatic islet hyperplasia J:123964
Prkcitm1Rfar/Prkcitm1Rfar
Tg(Ckmm-cre)5Khn/0
involves: 129P2/OlaHsd * C57BL/6 * FVB 		abnormal circulating lipid level J:123964
abnormal glucose homeostasis J:123964
decreased adipocyte glucose uptake J:123964
decreased cardiac muscle cell glucose uptake J:123964
decreased circulating HDL cholesterol level J:123964
decreased skeletal muscle cell glucose uptake J:123964
hepatic steatosis J:123964
impaired glucose tolerance J:123964
increased body weight J:123964
increased circulating cholesterol level J:123964
increased circulating free fatty acids level J:123964
increased circulating glucose level J:123964
increased circulating insulin level J:123964
increased circulating LDL cholesterol level J:123964
increased circulating leptin level J:123964
increased circulating triglyceride level J:123964
insulin resistance J:123964
pancreatic islet hyperplasia J:123964
Prkcitm1Rfar/Prkcitm1Rfar
Tg(NPHS2-cre)295Lbh/0
involves: 129P2/OlaHsd * C57BL/6 * SJL 		abnormal podocyte morphology J:164628
abnormal podocyte slit diaphragm morphology J:164628
abnormal podocyte slit junction morphology J:164628
dilated renal tubule J:164628
glomerulosclerosis J:164628
increased urine protein level J:164628
kidney failure J:164628
podocyte foot process effacement J:164628
postnatal growth retardation J:164628
premature death J:164628
renal cast J:164628
Prkcitm2.1(Prkcz)Ltg/Prkcitm2.1(Prkcz)Ltg
involves: 129P2/OlaHsd * NMRI 		embryonic growth retardation J:202124
embryonic lethality during organogenesis, incomplete penetrance J:202124
embryonic lethality, incomplete penetrance J:202124
lethality during fetal growth through weaning, complete penetrance J:202124
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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12/10/2024
MGI 6.24 		The Jackson Laboratory