Adora2a Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Adora2a
adenosine A2a receptor
MGI:99402

39 phenotypes from 5 alleles in 8 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Adora2a^em1(IMPC)H/Adora2a^em1(IMPC)H C57BL/6N-Adora2a^em1(IMPC)H/H	decreased hemoglobin content	J:211773
	decreased lean body mass	J:211773
	decreased locomotor activity	J:211773
	decreased lymphocyte cell number	J:211773
	increased circulating alanine transaminase level	J:211773
	increased circulating aspartate transaminase level	J:211773
	increased circulating glucose level	J:211773
	increased freezing behavior	J:211773
	increased neutrophil cell number	J:211773
	increased total body fat amount	J:211773
Adora2a^tm1Dyj/Adora2a^tm1.1Dyj Tg(Camk2a-cre)1Szi/0 involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA	abnormal locomotor activation	J:102700, J:104338
	impaired behavioral response to addictive substance	J:104338
Adora2a^tm1Dyj/Adora2a^tm1Dyj Tg(Camk2a-cre)1Szi/0 involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA	abnormal locomotor activation	J:104338
Adora2a^tm1Jfc/Adora2a^tm1Jfc B6.129S4-Adora2a^tm1Jfc	abnormal lung vasculature morphology	J:194389
	abnormal pulmonary artery morphology	J:194389
	heart right ventricle hypertrophy	J:194389
	increased right ventricle systolic pressure	J:194389
	pulmonary hypertension	J:194389
	vascular smooth muscle hypertrophy	J:194389
Adora2a^tm1Jfc/Adora2a^tm1Jfc involves: 129 * C57BL/6	abnormal locomotor activation	J:102700
Adora2a^tm1Jfc/Adora2a^tm1Jfc involves: 129S4/SvJae * 129S6/SvEvTac	normal cardiovascular system phenotype	J:73594
	decreased cerebral infarct size	J:73594
	decreased physiological sensitivity to xenobiotic	J:106215
	decreased susceptibility to ischemic brain injury	J:73594
	impaired behavioral response to addictive substance	J:106215, J:107988
Adora2a^tm1Jfc/Adora2a^tm1Jfc involves: 129S4/SvJae * C57BL/6	abnormal sclera morphology	J:164077
	normal cardiovascular system phenotype	J:73594
	decreased cerebral infarct size	J:73594
	decreased locomotor activity	J:73594, J:107988
	decreased susceptibility to ischemic brain injury	J:73594
	impaired behavioral response to addictive substance	J:99612, J:107988
	myopia	J:164077
	normal nervous system phenotype	J:73594, J:107988
	normal vision/eye phenotype	J:164077
Adora2a^tm1Map/Adora2a^tm1Map involves: 129S1/Sv * 129X1/SvJ * C57BL/6	decreased interleukin-10 secretion	J:147023
Adora2a^tm1Map/Adora2a^tm1Map involves: 129S1/Sv * 129X1/SvJ * CD-1	abnormal cardiovascular system physiology	J:42276
	abnormal liquid preference	J:104141
	abnormal locomotor activation	J:42276
	decreased exploration in new environment	J:42276
	hypoalgesia	J:42276
	impaired behavioral response to alcohol	J:97386
	increased aggression towards male mice	J:42276
	increased anxiety-related response	J:42276
	increased body mass index	J:42276
	increased heart rate	J:42276
	increased platelet aggregation	J:42276
	increased systemic arterial blood pressure	J:42276
	increased thermal nociceptive threshold	J:42276

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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