Adora2b Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Adora2b
adenosine A2b receptor
MGI:99403

35 phenotypes from 6 alleles in 10 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Adora2b^{tm1.1(KOMP)Vlcg}/Adora2b⁺ B6N(Cg)-Adora2b^{tm1.1(KOMP)Vlcg}/J	abnormal retina blood vessel morphology	J:211773
	convulsive seizures	J:211773
	increased fasting circulating glucose level	J:211773
Adora2b^{tm1.1(KOMP)Vlcg}/Adora2b^{tm1.1(KOMP)Vlcg} B6N(Cg)-Adora2b^{tm1.1(KOMP)Vlcg}/J	decreased circulating glucose level	J:211773
	increased circulating alkaline phosphatase level	J:211773
Adora2b^tm1.1Msit/Adora2b^tm1.1Msit either: (involves: C57BL/6) or (involves: C57BL/6 * CD-1 * ICR)	abnormal macrophage physiology	J:169155
	decreased susceptibility to induced morbidity/mortality	J:169155
	decreased susceptibility to injury	J:169155
	increased heart rate	J:169155
	increased interleukin-6 secretion	J:169155
	increased mean systemic arterial blood pressure	J:169155
	increased systemic arterial systolic blood pressure	J:169155
	increased tumor necrosis factor secretion	J:169155
Adora2b^tm1.1Msit/Adora2b^tm1.1Msit involves: BALB/cJ	increased susceptibility to injury	J:203572
Adora2b^tm1Dgen/Adora2b^tm1Dgen B6.129P2-Adora2b^tm1Dgen	abnormal dendritic cell physiology	J:138722
	abnormal penile erection	J:135978
	abnormal response to injury	J:131314
	decreased interleukin-10 secretion	J:147023
	increased vascular permeability	J:131314
Adora2b^tm1Dgen/Adora2b^tm1Dgen involves: 129P2/OlaHsd	abnormal response to cardiac infarction	J:131444
Adora2b^tm1Dgen/Adora2b^tm1Dgen involves: 129P2/OlaHsd	decreased susceptibility to injury	J:234143
Adora2b^tm1Kra/Adora2b^tm1Kra involves: 129 * C57BL/6J	abnormal cytokine level	J:111715
	abnormal inflammatory response	J:111715
	abnormal interleukin level	J:111715
	abnormal leukocyte adhesion	J:111715
	abnormal leukocyte migration	J:111715
	abnormal tumor necrosis factor level	J:111715
	normal cardiovascular system phenotype	J:111715
	decreased interleukin-10 secretion	J:111715
	enhanced leukocyte tethering or rolling	J:111715
	increased circulating interleukin-6 level	J:111715
Adora2b^tm1Msit/Adora2b^tm1Msit Lyz2^tm1(cre)Ifo/Lyz2⁺ involves: 129P2/OlaHsd * C57BL/6	decreased susceptibility to injury	J:169155
Adora2b^tm1Msit/Adora2b^tm1Msit Tg(Cdh5-cre)7Mlia/0 involves: FVB/N	normal homeostasis/metabolism phenotype	J:203572
Adora2b^tm1Msit/Adora2b^tm1Msit Tg(Sftpc-cre)1Blh/0 involves: C57BL/6 * DBA/2	increased susceptibility to injury	J:203572
Adora2b^tm1Till/Adora2b^tm1Till B6.129P2-Adora2b^tm1Till	abnormal cellular extravasation	J:125297
	decreased physiological sensitivity to xenobiotic	J:125297
	normal homeostasis/metabolism phenotype	J:125297
	impaired adaptive thermogenesis	J:125297
	increased interleukin-6 secretion	J:125297
	increased susceptibility to induced morbidity/mortality	J:125297
	increased susceptibility to type I hypersensitivity reaction	J:125297

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/19/2024 MGI 6.24