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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Nfe2l1
nuclear factor, erythroid derived 2,-like 1
MGI:99421
40 phenotypes from 7 alleles in 9 genetic backgrounds
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Allelic Composition
Genetic Background		 Annotated Term Reference
Nfe2l1tm1.1Mym/Nfe2l1+
B6J.Cg-Nfe2l1tm1.1Mym 		decreased circulating glucose level J:230118
decreased circulating insulin level J:230118
normal growth/size/body region phenotype J:230118
Nfe2l1tm1.1Mym/Nfe2l1tm1.1Mym
involves: C57BL/6J 		embryonic lethality during organogenesis, complete penetrance J:143468
Nfe2l1tm1Jefc/Nfe2l1tm1Ywk
Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
involves: 129X1/SvJ * C57BL/6J 		hepatic necrosis J:97188
hepatic steatosis J:97188
increased circulating alanine transaminase level J:97188
increased hepatocellular carcinoma incidence J:97188
increased liver adenoma incidence J:97188
liver fibrosis J:97188
liver inflammation J:97188
Nfe2l1tm1Mym/Nfe2l1tm1Mym
Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
involves: C57BL/6 * DBA 		hepatic steatosis J:143468
increased circulating alanine transaminase level J:143468
increased circulating aspartate transaminase level J:143468
Nfe2l1tm1Tow/Nfe2l1tm1Tow
involves: 129S1/Sv * 129X1/SvJ 		abnormal hematopoietic system morphology/development J:39447
absent mesoderm J:39447
embryonic lethality between implantation and somite formation, incomplete penetrance J:39447
failure of primitive streak formation J:39447
Nfe2l1tm1Ywk/Nfe2l1tm1Ywk
involves: 129X1/SvJ 		oxidative stress J:86725
Nfe2l1tm1Ywk/Nfe2l1tm1Ywk
involves: 129X1/SvJ * C57BL/6J 		abnormal erythropoiesis J:46990
anemia J:46990
decreased embryo size J:46990
decreased hematocrit J:46990
embryonic growth retardation J:46990
increased nucleated erythrocyte cell number J:46990
lethality throughout fetal growth and development, incomplete penetrance J:46990
neonatal lethality, complete penetrance J:46990
pale liver J:46990
pallor J:46990
small liver J:46990
Tg(Mafg-Nfe2l1)1Mym/0
B6J.Cg-Tg(Mafg-Nfe2l1)1Mym 		decreased body weight J:230118
normal homeostasis/metabolism phenotype J:230118
Tg(Mafg-Nfe2l1)1Mym/0
involves: C57BL/6J * DBA/2 		abnormal blood homeostasis J:230118
abnormal glucose homeostasis J:230118
abnormal pancreatic beta cell morphology J:230118
decreased body weight J:230118
decreased circulating ammonia level J:230118
enlarged pancreatic islets J:230118
hyperglycemia J:230118
increased circulating insulin level J:230118
increased liver weight J:230118
increased susceptibility to diet-induced non-insulin dependent diabetes J:230118
insulin resistance J:230118
Tg(Mafg-Nfe2l1)6Mym/0
B6J.Cg-Tg(Mafg-Nfe2l1)6Mym 		decreased body weight J:230118
normal homeostasis/metabolism phenotype J:230118
Tg(Mafg-Nfe2l1)6Mym/0
involves: C57BL/6J * DBA/2 		abnormal pancreatic beta cell morphology J:230118
decreased body weight J:230118
enlarged pancreatic islets J:230118
hyperglycemia J:230118
increased circulating insulin level J:230118
increased liver weight J:230118
increased susceptibility to diet-induced non-insulin dependent diabetes J:230118
insulin resistance J:230118
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory