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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Hira
histone cell cycle regulator
MGI:99430
48 phenotypes from 4 alleles in 5 genetic backgrounds
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Allelic Composition
Genetic Background		 Annotated Term Reference
Hiratm1a(EUCOMM)Wtsi/Hira+
C57BL/6N-Hiratm1a(EUCOMM)Wtsi/Wtsi 		decreased leukocyte cell number J:175295
decreased rib number J:175295
Hiratm1Pjs/Hiratm1Pjs
involves: 129S1/Sv * C57BL/6 		abnormal axial mesoderm morphology J:75491
abnormal brain development J:75491
abnormal developmental patterning J:75491
abnormal embryo turning J:75491
abnormal embryonic neuroepithelium morphology J:75491
abnormal embryonic tissue morphology J:75491
abnormal head mesenchyme morphology J:75491
abnormal head morphology J:75491
abnormal heart development J:75491
abnormal heart morphology J:75491
abnormal hindbrain development J:75491
abnormal left-right axis patterning J:75491
abnormal mesendoderm development J:75491
abnormal midbrain-hindbrain boundary development J:75491
abnormal neural plate morphology J:75491
abnormal neural tube morphology J:75491
abnormal notochord morphology J:75491
abnormal pharyngeal arch morphology J:75491
abnormal prechordal plate morphology J:75491
abnormal primitive streak morphology J:75491
abnormal somite shape J:75491
decreased embryo size J:75491
decreased somite size J:75491
embryonic growth arrest J:75491
embryonic growth retardation J:75491
embryonic lethality during organogenesis, complete penetrance J:75491
embryonic-extraembryonic boundary constriction J:75491
enlarged allantois J:75491
failure of chorioallantoic fusion J:75491
failure to gastrulate J:75491
incomplete somite formation J:75491
kinked neural tube J:75491
open neural tube J:75491
Hiratm1Pjs/Hiratm1Pjs
involves: 129S1/Sv * C57BL/6 * CD-1 		abnormal allantois morphology J:75491
abnormal blood vessel morphology J:75491
abnormal brain development J:75491
abnormal embryo development J:75491
abnormal embryo turning J:75491
abnormal forebrain morphology J:75491
abnormal head morphology J:75491
abnormal heart development J:75491
abnormal heart tube morphology J:75491
abnormal paraxial mesoderm morphology J:75491
abnormal rostral-caudal axis patterning J:75491
abnormal somite shape J:75491
abnormal vitelline vasculature morphology J:75491
caudal body truncation J:75491
decreased somite size J:75491
normal embryo phenotype J:75491
embryonic growth retardation J:75491
embryonic lethality during organogenesis, complete penetrance J:75491
failure of heart looping J:75491
failure to gastrulate J:75491
irregular heartbeat J:75491
pericardial edema J:75491
Hiratm2Pjs/Hiratm2Pjs
involves: 129S6/SvEvTac * C57BL/6 		abnormal embryo development J:75491
embryonic lethality during organogenesis, complete penetrance J:75491
HiraTn(mm-DTT-3XSstop)L.1Ddra/HiraTn(mm-DTT-3XSstop)L.1Ddra
involves: 129P2/OlaHsd * 129S4/SvJaeSor * C57BL/6 * FVB/N 		abnormal embryo development J:156413
embryonic lethality during organogenesis, complete penetrance J:156413
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory