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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Ifit2
interferon-induced protein with tetratricopeptide repeats 2
MGI:99449
17 phenotypes from 2 alleles in 3 genetic backgrounds
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Allelic Composition
Genetic Background		 Annotated Term Reference
Ifit2tm1.1Ebsb/Ifit2tm1.1Ebsb
B6.129P2(C)-Ifit2tm1.1Ebsb 		enhanced humoral immune response J:233986
increased IgE level J:233986
increased IgG1 level J:233986
increased IgG3 level J:233986
increased IgM level J:233986
Ifit2tm1.1Ebsb/Ifit2tm1.1Ebsb
B6NCrl.129P2(C)-Ifit2tm1.1Ebsb 		decreased circulating interleukin-1 beta level J:199862
decreased circulating interleukin-6 level J:199862
decreased circulating interleukin-12b level J:199862
decreased circulating tumor necrosis factor level J:199862
decreased interleukin-6 secretion J:199862
decreased tumor necrosis factor secretion J:199862
increased susceptibility to bacterial infection induced morbidity/mortality J:199862
Ifit2tm1.1Tac/Ifit2+
involves: C57BL/6 		increased susceptibility to Riboviria infection induced morbidity/mortality J:195382
Ifit2tm1.1Tac/Ifit2tm1.1Tac
involves: C57BL/6 		ataxia J:195382
hindlimb paralysis J:195382
increased susceptibility to Riboviria infection J:195382
increased susceptibility to Riboviria infection induced morbidity/mortality J:195382
induced hyperactivity J:195382
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory