Irs1 Phenotype Annotations - Multigenic Genotypes

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Irs1
insulin receptor substrate 1
MGI:99454

34 phenotypes from multigenic genotypes

Allelic Composition Genetic Background	Annotated Term	Reference
Foxo1^tm1Rdp/Foxo1^tm1Rdp Irs1^tm1Mfw/Irs1^tm1Mfw Irs2^tm2Mfw/Irs2^tm2Mfw Speer6-ps1^{Tg(Alb-cre)21Mgn}/Speer6-ps1⁺ involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * DBA * FVB	abnormal triglyceride level	J:137845
	decreased circulating cholesterol level	J:137845
	decreased circulating free fatty acids level	J:137845
	decreased circulating HDL cholesterol level	J:137845
	decreased circulating triglyceride level	J:137845
	normal homeostasis/metabolism phenotype	J:137845
Gck^tm1Tka/Gck⁺ Irs1^tm1Tka/Irs1^tm1Tka involves: 129X1/SvJ * C57BL/6 * CBA * ICR	decreased body weight	J:38899
	impaired glucose tolerance	J:38899
	increased circulating insulin level	J:38899
	increased pancreatic beta cell mass	J:38899
	insulin resistance	J:38899
	pancreatic islet hyperplasia	J:38899
	postnatal growth retardation	J:38899
Irs1^smla/Irs1^smla Serpinb2^tm2Dgi/Serpinb2^tm2Dgi involves: 129S2/SvPas * C57BL/6J * DBA/2J	decreased birth body size	J:164568
	decreased body height	J:164568
	decreased body size	J:52283, J:164568
	decreased body weight	J:164568
	muscular atrophy	J:164568
	postnatal lethality	J:164568
	premature death	J:164568
Irs1^tm1Jos/Irs1⁺ Irs2^tm2Mfw/Irs2^tm2Mfw Tg(Ins2-cre)25Mgn/0 involves: 129S1/Sv * 129X1/SvJ * C57BL/6	abnormal pancreatic beta cell morphology	J:93415
	decreased body weight	J:93415
	decreased circulating insulin level	J:93415
	hyperglycemia	J:93415
Irs1^tm1Jos/Irs1^tm1Jos Irs3^tm1Lhd/Irs3^tm1Lhd involves: 129S2/SvPas * 129S4/SvJae * C57BL/6	abnormal gonadal fat pad morphology	J:80976
	decreased circulating free fatty acids level	J:80976
	decreased circulating leptin level	J:80976
	decreased circulating triglyceride level	J:80976
	decreased triglyceride level	J:80976
	decreased white adipose tissue amount	J:80976
	hyperglycemia	J:80976
	impaired glucose tolerance	J:80976
	increased circulating insulin level	J:80976
	increased pancreatic beta cell mass	J:80976
	insulin resistance	J:80976
	normal liver/biliary system phenotype	J:80976
	normal mortality/aging	J:80976
	pancreatic islet hyperplasia	J:80976
	postnatal growth retardation	J:80976
Irs1^tm1Jos/Irs1^tm1Jos Irs4^tm1Lhd/Y involves: 129S2/SvPas * 129S4/SvJae * C57BL/6	impaired glucose tolerance	J:80976
	increased circulating insulin level	J:80976
	insulin resistance	J:80976
	postnatal growth retardation	J:80976
Irs1^tm1Jos/Irs1^tm1Jos Irs4^tm1Lhd/Irs4^tm1Lhd involves: 129S2/SvPas * 129S4/SvJae * C57BL/6	impaired glucose tolerance	J:80976
	increased circulating insulin level	J:80976
	insulin resistance	J:80976
	postnatal growth retardation	J:80976
Irs1^tm1Mfw/Irs1⁺ Irs2^tm2Mfw/Irs2^tm2Mfw Speer6-ps1^{Tg(Alb-cre)21Mgn}/Speer6-ps1⁺ involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * DBA * FVB/N	impaired glucose tolerance	J:156999
Irs1^tm1Mfw/Irs1^tm1Mfw Irs2^tm2Mfw/Irs2^tm2Mfw Speer6-ps1^{Tg(Alb-cre)21Mgn}/Speer6-ps1⁺ involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * DBA	abnormal triglyceride level	J:137845
	decreased body size	J:137845
	decreased circulating cholesterol level	J:137845
	decreased circulating free fatty acids level	J:137845
	decreased circulating HDL cholesterol level	J:137845
	decreased circulating triglyceride level	J:137845
	decreased liver glycogen level	J:137845
	hyperglycemia	J:137845
	impaired glucose tolerance	J:137845
	increased circulating glucose level	J:137845
	increased circulating insulin level	J:137845
	increased susceptibility to autoimmune diabetes	J:137845
	insulin resistance	J:137845
Irs1^tm1Mfw/Irs1^tm2.1Mfw Irs2^tm2Mfw/Irs2^tm2Mfw Speer6-ps1^{Tg(Alb-cre)21Mgn}/Speer6-ps1⁺ involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * DBA * FVB/N	impaired glucose tolerance	J:156999
	increased circulating insulin level	J:156999
	insulin resistance	J:156999
Irs1^tm1Tka/Irs1^tm1Tka Irs2^tm1Tka/Irs2^tm1Tka involves: C57BL/6 * CBA	abnormal cell differentiation	J:68004
	decreased white adipose tissue amount	J:68004
Irs1^tm2.1Mfw/Irs1^tm2.1Mfw Irs2^tm2Mfw/Irs2^tm2Mfw Speer6-ps1^{Tg(Alb-cre)21Mgn}/Speer6-ps1⁺ involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * DBA * FVB/N	impaired glucose tolerance	J:156999
	increased circulating insulin level	J:156999
Irs1^tm2Tka/Irs1^tm2Tka Irs2^tm2Tka/Irs2^tm2Tka Speer6-ps1^{Tg(Alb-cre)21Mgn}/Speer6-ps1⁺ involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6 * DBA	increased susceptibility to autoimmune diabetes	J:137846
	insulin resistance	J:137846
Irs1^tm3.1Mfw/Irs1^tm3.1Mfw involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * FVB/N	decreased body length	J:156999
	decreased body weight	J:156999
	decreased bone mineral density	J:156999

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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