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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Mef2c
myocyte enhancer factor 2C
MGI:99458
79 phenotypes from 8 alleles in 14 genetic backgrounds
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Allelic Composition
Genetic Background		 Annotated Term Reference
Ighg1tm1(cre)Cgn/0
Mef2ctm2Eno/Mef2ctm2Eno
involves: 129P2/OlaHsd * 129S/SvEv * C57BL/6 		decreased germinal center B cell number J:265465
Mef2cm1Anu/Mef2c+
C57BL/6NCrlAnu-Mef2cm1Anu/Anu 		no abnormal phenotype detected J:104190
Mef2cm1Anu/Mef2cm1Anu
C57BL/6NCrlAnu-Mef2cm1Anu/Anu 		prenatal lethality J:104190
Mef2ctm1.1Jjs/Mef2ctm1.1Jjs
involves: 129S4/SvJaeSor * 129S6/SvEvTac 		embryonic growth retardation J:100949
increased sinoatrial node size J:100949
ventricular hypoplasia J:100949
Mef2ctm1Eno/Mef2c+
involves: 129S7/SvEvBrd 		failure of sternum ossification J:119152
normal mortality/aging J:122483
Mef2ctm1Eno/Mef2ctm1Eno
involves: 129S7/SvEvBrd 		abnormal blood vessel morphology J:56426
abnormal cardiovascular system morphology J:40724
abnormal definitive hematopoiesis J:56426
abnormal heart development J:40724
abnormal sinus venosus morphology J:40724
abnormal vitelline vasculature morphology J:56426
decreased cardiac muscle contractility J:40724
decreased heart ventricle muscle contractility J:40724
embryonic growth retardation J:40724
embryonic lethality during organogenesis, complete penetrance J:40724
failure of heart looping J:40724
incomplete somite formation J:40724
trabecula carnea hypoplasia J:40724
ventricular hypoplasia J:40724
Mef2ctm1Eno/Mef2ctm1Eno
involves: 129S7/SvEvBrd * C57BL/6 		abnormal dorsal aorta morphology J:50309
abnormal endocardium morphology J:50309
abnormal pharyngeal arch artery morphology J:50309
abnormal vascular development J:50309
abnormal vascular endothelial cell development J:50309
abnormal vitelline vasculature morphology J:50309
dilated dorsal aorta J:50309
thin ventricular wall J:50309
Mef2ctm1Eno/Mef2ctm1Jjs
H2az2Tg(Wnt1-cre)11Rth/H2az2+
involves: 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6J * CBA/J 		abnormal craniofacial development J:122483
abnormal dermal melanocyte morphology J:173609
abnormal epidermal melanocyte morphology J:173609
abnormal head morphology J:122483
abnormal mandibular angle morphology J:122483
abnormal melanocyte differentiation J:173609
abnormal melanosome morphology J:173609
abnormal pharyngeal arch morphology J:122483
abnormal respiratory system morphology J:122483
absent tympanic ring J:122483
cleft palate J:122483
cyanosis J:122483
decreased melanocyte number J:173609
decreased skin pigmentation J:173609
delayed bone ossification J:122483
glossoptosis J:122483
mandible hypoplasia J:122483
mandibular condyloid process hypoplasia J:122483
mandibular coronoid process hypoplasia J:122483
Meckel's cartilage hypoplasia J:122483
neonatal lethality, complete penetrance J:122483
normal nervous system phenotype J:173609
short mandible J:122483
temporal bone hypoplasia J:122483
zygomatic arch hypoplasia J:122483
Mef2ctm1Eno/Mef2ctm1Jjs
Myl2tm1(cre)Krc/Myl2+
involves: 129S4/SvJae * 129S6/SvEvTac * 129S7/SvEvBrd 		no abnormal phenotype detected J:100949
Mef2ctm1Eno/Mef2ctm1Jjs
Tg(Myh6-cre)2182Mds/0
involves: 129S4/SvJaeSor * 129S6/SvEvTac * 129S7/SvEvBrd * FVB/N 		no abnormal phenotype detected J:100949
Mef2ctm1Eno/Mef2ctm2Eno
Tg(Col2a1-cre)1Bhr/0
involves: 129S/SvEv * 129S7/SvEvBrd * C57BL/6 * SJL 		abnormal endochondral bone ossification J:119152
abnormal gait J:119152
decreased length of long bones J:119152
failure of sternum ossification J:119152
short limbs J:119152
Mef2ctm1Eno/Mef2ctm2Eno
Tg(Myog-cre)1Eno/0
involves: 129S/SvEv * 129S7/SvEvBrd 		abnormal skeletal muscle fiber type ratio J:127416
Mef2ctm1Eno/Mef2ctm2Eno
Twist2tm1(cre)Dor/Twist2+
involves: 129S/SvEv * 129S7/SvEvBrd * 129X1/SvJ 		abnormal endochondral bone ossification J:119152
abnormal trabecular bone morphology J:119152
failure of endochondral bone ossification J:119152
postnatal lethality, complete penetrance J:119152
respiratory distress J:119152
short fibula J:119152
short limbs J:119152
short tibia J:119152
Mef2ctm1Jjs/Mef2ctm1Jjs
Tg(Slc5a2-cre)1Tauc/0
involves: 129S6/SvEvTac * C57BL/6 * DBA/2 		dilated distal convoluted tubule J:158762
dilated proximal convoluted tubule J:158762
dilated renal tubule J:158762
increased kidney cell proliferation J:158762
kidney cortex cyst J:158762
Tg(Col2a1-Mef2c/VP16)1Eno/0
Not Specified 		abnormal epiphyseal plate morphology J:119152
abnormal forelimb morphology J:119152
abnormal neurocranium morphology J:119152
premature endochondral bone ossification J:119152
short limbs J:119152
Tg(Myh6-Mef2c)2Jmol/0
involves: FVB 		abnormal heart atrium morphology J:111573
cardiac hypertrophy J:111573
decreased cardiac muscle contractility J:111573
dilated cardiomyopathy J:111573
dilated heart left ventricle J:111573
dilated heart ventricle J:111573
increased heart ventricle size J:111573
Tg(Myh6-Mef2c/VP16)1Eno/0
Not Specified 		abnormal skeletal muscle fiber type ratio J:127416
enhanced exercise endurance J:127416
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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12/10/2024
MGI 6.24 		The Jackson Laboratory