Mef2c Phenotype Annotations - Multigenic Genotypes

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Mef2c
myocyte enhancer factor 2C
MGI:99458

25 phenotypes from multigenic genotypes

Allelic Composition Genetic Background	Annotated Term	Reference
Del(6Dlx6-Dlx5)1Tlu/+ Mef2c^tm1Eno/Mef2c⁺ involves: 129S7/SvEvBrd	abnormal palate development	J:122483
	cyanosis	J:122483
	glossoptosis	J:122483
	neonatal lethality, complete penetrance	J:122483
Gt(ROSA)26Sor^tm1Sor/Gt(ROSA)26Sor⁺ Mef2c^tm1Eno/Mef2c^tm1Jjs H2az2^{Tg(Wnt1-cre)11Rth}/H2az2⁺ involves: 129S4/SvJaeSor * 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6J * CBA/J	normal embryo phenotype	J:122483
Hdac4^tm1Eno/Hdac4^tm1Eno Mef2c^tm1Eno/Mef2c⁺ involves: 129S7/SvEvBrd	normal skeleton phenotype	J:119152
Ighg1^tm1(cre)Cgn/0 Mef2b^tm1.1Rdf/Mef2b^tm1.1Rdf Mef2c^tm2Eno/Mef2c^tm2Eno involves: 129P2/OlaHsd * 129S/SvEv * C57BL/6	decreased germinal center B cell number	J:265465
Mef2a^tm1.1Limm/Mef2a^tm1.1Limm Mef2c^tm1Jjs/Mef2c^tm1Jjs Tg(Cdh5-cre/ERT2)1Rha/0 involves: 129S/SvEv * 129S6/SvEvTac	abnormal retina vasculature morphology	J:334208
	decreased angiogenesis	J:334208
Mef2a^tm1.1Limm/Mef2a^tm1.1Limm Mef2c^tm2Eno/Mef2c^tm2Eno Mef2d^tm3Eno/Mef2d^tm3Eno Tg(GFAP-cre)25Mes/0 involves: 129S/SvEv * C57BL/6 * FVB/N	abnormal long-term potentiation	J:207812
	decreased body weight	J:207812
	decreased brain size	J:207812
	enhanced paired-pulse facilitation	J:207812
	increased neuron apoptosis	J:207812
	normal nervous system phenotype	J:207812
	premature death	J:207812
Mef2c^tm1.1Wtp/Mef2c^tm1.1Wtp involves: 129S4/SvJae * C57BL/6 * SJL * Swiss Webster	perinatal lethality	J:185868
Mef2c^tm1Eno/Mef2c⁺ Mef2d^tm1.1Eno/Mef2d⁺ involves: 129S7/SvEvBrd	failure of sternum ossification	J:119152
	neonatal lethality, complete penetrance	J:119152
Mef2c^tm1Jjs/Mef2c^tm1Jjs Mir223^tm1Fcam/Mir223^tm1Fcam Lyz2^tm1(cre)Ifo/Lyz2⁺ involves: 129 * C57BL/6	abnormal neutrophil differentiation	J:140009
	abnormal neutrophil physiology	J:140009
	increased neutrophil cell number	J:140009
Mef2c^tm2Eno/Mef2c^tm2Eno Mef2d^tm1Eno/Mef2d^tm1Eno Tg(Col2a1-cre)1Bhr/0 involves: 129S/SvEv * C57BL/6 * SJL	failure of endochondral bone ossification	J:119152
Tg(Myh6-Mef2c)2Jmol/0 Tg(Myh6-Ppp3ca)37Eno/0 involves: FVB	abnormal heart atrium morphology	J:111573
	cardiac hypertrophy	J:111573
	decreased cardiac muscle contractility	J:111573

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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