Nr3c2 Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Nr3c2
nuclear receptor subfamily 3, group C, member 2
MGI:99459

41 phenotypes from 6 alleles in 7 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Nr3c2^m1Btlr/Nr3c2^m1Btlr C57BL/6J-Nr3c2^m1Btlr	decreased body weight	J:225269
Nr3c2^tm1.1Ics/Nr3c2^tm1.1Ics Tg(Acta2-cre/ERT2)#Pcn/0 involves: 129S2/SvPas * FVB/N	abnormal muscle tone	J:193438
	abnormal redox activity	J:193438
	abnormal vasoconstriction	J:193438
	abnormal vasodilation	J:193438
	normal cardiovascular system phenotype	J:193438
	decreased heart weight	J:193438
	decreased systemic arterial systolic blood pressure	J:193438
	decreased vasoconstriction	J:193438
	increased vasoconstriction	J:193438
	increased vasodilation	J:193438
	normal renal/urinary system phenotype	J:193438
Nr3c2^tm1Gsc/Nr3c2⁺ involves: 129P2/OlaHsd * C57BL/6	abnormal renal sodium ion transport	J:77285
	increased circulating aldosterone level	J:77285
	increased circulating angiotensin II level	J:77285
	increased circulating renin level	J:77285
	increased renin activity	J:77285
	increased urine sodium level	J:77285
Nr3c2^tm1Gsc/Nr3c2^tm1Gsc involves: 129P2/OlaHsd * C57BL/6	abnormal extraglomerular mesangial cell morphology	J:77285
	abnormal ion homeostasis	J:77285
	abnormal juxtaglomerular apparatus morphology	J:77285
	abnormal juxtaglomerular cell morphology	J:77285
	abnormal macula densa morphology	J:77285
	abnormal renal glomerulus morphology	J:77285
	abnormal renal sodium ion transport	J:77285
	abnormal renal sodium reabsorption	J:77285
	decreased circulating sodium level	J:77285
	dehydration	J:77285
	hypovolemia	J:77285
	increased circulating aldosterone level	J:77285
	increased circulating angiotensin II level	J:77285
	increased circulating potassium level	J:77285
	increased circulating renin level	J:77285
	increased hematocrit	J:77285
	increased renin activity	J:77285
	increased urine sodium level	J:77285
	postnatal lethality, complete penetrance	J:77285
	normal renal/urinary system phenotype	J:77285
	weight loss	J:77285
Nr3c2^tm1Krst/Nr3c2^tm1Krst Tg(Camk2a-cre)2Gsc/? involves: FVB/N	abnormal miniature excitatory postsynaptic currents	J:104691
Nr3c2^tm2.1Gsc/Nr3c2^tm2.1Gsc involves: C57BL/6	postnatal lethality	J:104549
Nr3c2^tm2Gsc/Nr3c2^tm2Gsc Tg(Aqp2-cre/ERT2)4Gsc/0 involves: C57BL/6 * FVB/N	normal homeostasis/metabolism phenotype	J:169670
	increased circulating aldosterone level	J:169670
	increased urine sodium level	J:169670
	polyuria	J:169670
Nr3c2^tm2Gsc/Nr3c2^tm2Gsc Tg(Camk2a-cre)2Gsc/0 involves: 129P2/OlaHsd * C57BL/6 * FVB/N	abnormal hippocampal mossy fiber morphology	J:104549
	abnormal response to novel object	J:104549
	abnormal spatial learning	J:104549
	abnormal spatial working memory	J:104549
	normal behavior/neurological phenotype	J:104549

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24