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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Notch3
notch 3
MGI:99460
72 phenotypes from 12 alleles in 14 genetic backgrounds
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Allelic Composition
Genetic Background		 Annotated Term Reference
Gt(ROSA)26Sortm2(CAG-Dsred2/EGFP)Luo/Gt(ROSA)26Sortm1(Notch3*)Sfr
Notch3tm1.1(cre/ERT2)Sat/Notch3+
involves: 129S1/Sv * 129X1/SvJ * C57BL/6NTac 		decreased mammary gland epithelial cell proliferation J:201985
Notch3em1Ecan/Notch3+
C57BL/6J-Notch3em1Ecan 		abnormal bone mineralization J:270682
abnormal bone trabecula morphology J:270682
abnormal osteoclast differentiation J:270682
normal behavior/neurological phenotype J:270682
decreased body weight J:270682
decreased bone mineral density J:270682
decreased bone trabecula number J:270682
decreased bone volume J:270682
decreased compact bone thickness J:270682
decreased trabecular bone connectivity density J:270682
decreased trabecular bone volume J:270682
increased bone ossification J:270682
increased osteoblast cell number J:270682
increased osteoblast proliferation J:270682
increased osteoclast cell number J:270682
increased osteocyte number J:270682
Notch3Gt(PST033)Byg/Notch3Gt(PST033)Byg
involves: 129P2/OlaHsd 		normal cardiovascular system phenotype J:133358
increased cerebral infarct size J:133358
increased susceptibility to induced morbidity/mortality J:133358
increased susceptibility to ischemic brain injury J:133358
normal nervous system phenotype J:133358
Notch3hpbk/Notch3hpbk
C57BL/6J-Notch3hpbk/GrsrJ 		abnormal pregnancy J:157222
cachexia J:157222
hydrocephaly J:157222
impaired hearing J:157222
increased or absent threshold for auditory brainstem response J:157222
kyphosis J:157222
male infertility J:157222
myopathy J:157222
phimosis J:157222
premature death J:157222
skeletal muscle atrophy J:157222
Notch3tm1.1(cre/ERT2)Sat/Notch3+
C57BL/6-Notch3tm1.1(cre/ERT2)Sat 		no abnormal phenotype detected J:179632
Notch3tm1.1(KOMP)Vlcg/Notch3tm1.1(KOMP)Vlcg
C57BL/6N-Notch3tm1.1(KOMP)Vlcg/Ucd 		abnormal kidney morphology J:211773
decreased liver weight J:211773
decreased prepulse inhibition J:211773
enlarged kidney J:211773
improved glucose tolerance J:211773
increased heart weight J:211773
increased kidney weight J:211773
increased neutrophil cell number J:211773
increased red blood cell distribution width J:211773
increased spleen weight J:211773
Notch3tm1.1Dwr/Notch3+
involves: 129S/SvEv * Swiss 		abnormal artery morphology J:191454
abnormal brain thrombosis J:191454
abnormal motor capabilities/coordination/movement J:191454
ataxia J:191454
brain lesion J:191454
normal cardiovascular system phenotype J:191454
decreased exploration in new environment J:191454
gliosis J:191454
paresis J:191454
Notch3tm1.1Dwr/Notch3tm1.1Dwr
involves: 129S/SvEv * Swiss 		abnormal artery morphology J:191454
abnormal brain thrombosis J:191454
abnormal motor capabilities/coordination/movement J:191454
ataxia J:191454
brain lesion J:191454
normal cardiovascular system phenotype J:191454
decreased exploration in new environment J:191454
gliosis J:191454
paresis J:191454
Notch3tm1Grid/Notch3tm1Grid
129S1/SvImJ-Notch3tm1Grid 		no abnormal phenotype detected J:87272
Notch3tm1Grid/Notch3tm1Grid
involves: 129S1/Sv 		abnormal artery morphology J:94047
abnormal blood circulation J:94047
abnormal vascular resistance J:94047
abnormal vascular smooth muscle morphology J:94047
poor arterial differentiation J:94047
Notch3tm1Grid/Notch3tm1Grid
involves: 129S1/Sv * C57BL/6 		abnormal pericyte morphology J:227333
abnormal retina blood vessel morphology J:227333
abnormal vascular smooth muscle morphology J:227333
Notch3tm1Grid/Notch3tm1Grid
involves: 129S1/Sv * C57BL/6J 		no abnormal phenotype detected J:87272
Notch3tm1Khan/Notch3tm1Khan
involves: C57BL/6 * CBA 		decreased thymocyte number J:98284
small thymus J:98284
Notch3tm1Ul/Notch3+
Not Specified 		normal cardiovascular system phenotype J:95927
no abnormal phenotype detected J:95927
Notch3tm1Ul/Notch3tm1Ul
Not Specified 		normal cardiovascular system phenotype J:95927
no abnormal phenotype detected J:95927
Tg(Lck-Notch3)#Issc/0
involves: C57BL/6 * DBA/2 		abnormal T cell differentiation J:63300
enlarged lymph nodes J:63300
enlarged spleen J:63300
hunched posture J:63300
increased acute lymphoblastic leukemia incidence J:63300
increased double-negative T cell number J:63300
increased lymphoblastic lymphoma incidence J:63300
increased T cell derived lymphoma incidence J:96010
increased thymocyte number J:63300
lethargy J:63300
premature death J:63300, J:96010
thymus hyperplasia J:63300
Tg(Pdx1-Notch3)1Heed/?
involves: C57BL/6 * CBA 		abnormal pancreas development J:57072
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory