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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Cebpa
CCAAT/enhancer binding protein alpha
MGI:99480
109 phenotypes from 17 alleles in 18 genetic backgrounds
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Allelic Composition
Genetic Background		 Annotated Term Reference
Cebpam4443Dajl/Cebpam4443Dajl
involves: C3H/HeSnJ * C57BL/6J * SWR 		decreased body weight J:149088
increased circulating cholesterol level J:149088
increased circulating HDL cholesterol level J:149088
increased circulating LDL cholesterol level J:149088
increased circulating triglyceride level J:149088
Cebpatm1.1(cre)Touw/Cebpa+
involves: 129/Sv * 129X1/SvJ * C57BL/6 		normal hematopoietic system phenotype J:166620
Cebpatm1.1Gonz/Cebpatm1.1Gonz
involves: 129X1/SvJ * C57BL/6 		perinatal lethality J:42995
Cebpatm1Btp/Cebpatm1Btp
involves: 129P2/OlaHsd * C57BL/6 		no abnormal phenotype detected J:105554
Cebpatm1Dgt/Cebpatm1Dgt
involves: 129S6/SvEvTac 		no abnormal phenotype detected J:94682
Cebpatm1Dgt/Cebpatm1Dgt
Tg(Mx1-cre)1Cgn/0
involves: 129S6/SvEvTac * C57BL/6 * CBA 		abnormal myelopoiesis J:94682
decreased granulocyte number J:94682
failure of myelopoiesis J:94682
premature death J:94682
sepsis J:94682
Cebpatm1Dgt/Cebpatm1Dgt
Tg(SFTPC-rtTA)5Jaw/0
Tg(tetO-cre)1Jaw/0
involves: 129 * 129S6/SvEvTac * C57BL/6 		abnormal pulmonary alveolus epithelial cell morphology J:105593
abnormal pulmonary alveolus morphology J:105593
abnormal surfactant secretion J:105593
abnormal type II pneumocyte morphology J:105593
absent alveolar lamellar bodies J:105593
absent type I pneumocytes J:105593
absent type II pneumocytes J:105593
normal hematopoietic system phenotype J:105593
increased pulmonary alveolus wall thickness J:105593
normal liver/biliary system phenotype J:105593
neonatal lethality, incomplete penetrance J:105593
respiratory distress J:105593
respiratory failure J:105593
Cebpatm1Gjd/Cebpatm1Gjd
B6.129S7-Cebpatm1Gjd 		absent common myeloid progenitor cells J:94682
failure of myelopoiesis J:94682
Cebpatm1Gjd/Cebpatm1Gjd
involves: 129/Sv * 129S7/SvEvBrd * C57BL/6 		normal endocrine/exocrine gland phenotype J:48513
normal reproductive system phenotype J:48513
Cebpatm1Gjd/Cebpatm1Gjd
involves: 129S7/SvEvBrd * C57BL/6 		abnormal energy expenditure J:28320
abnormal gluconeogenesis J:28320
abnormal glucose homeostasis J:28320
abnormal glycogen homeostasis J:28320
abnormal hepatocyte morphology J:28320
abnormal inguinal fat pad morphology J:28320
abnormal lipid homeostasis J:28320
abnormal liver morphology J:28320
abnormal lung morphology J:28320
abnormal pulmonary alveolus morphology J:105087
abnormal pulmonary alveolus wall morphology J:105087
abnormal surfactant secretion J:105087
absent gastric milk in neonates J:28320
decreased body weight J:28320
decreased brown adipose tissue amount J:28320
decreased circulating serum albumin level J:28320
decreased liver glycogen level J:28320
decreased white adipose tissue amount J:28320
normal digestive/alimentary phenotype J:46862
hypoglycemia J:28320
increased circulating tyrosine level J:28320
increased type II pneumocyte number J:105087
lethargy J:28320
neonatal lethality, complete penetrance J:28320
perinatal lethality, incomplete penetrance J:28320
slow postnatal weight gain J:28320
Cebpatm1Gonz/Cebpatm1Gonz
Tg(Alb1-cre)1Dlr/0
involves: 129X1/SvJ * FVB/N 		increased circulating free fatty acids level J:93579
Cebpatm1Gonz/Cebpatm1Gonz
Tg(KRT5-cre)5132Jlj/0
involves: 129X1/SvJ * C57BL/6 * DBA/2J 		increased skin papilloma incidence J:123139
increased skin tumor incidence J:123139
increased squamous cell carcinoma incidence J:123139
increased tumor growth/size J:123139
normal integument phenotype J:123139
Cebpatm1Gonz/Cebpatm1Gonz
Tg(KRT14-cre/ERT)20Efu/0
involves: 129X1/SvJ * C57BL/6 * CD-1 		epidermal hyperplasia J:158721
increased keratinocyte proliferation J:158721
normal integument phenotype J:158721
thick epidermis J:158721
Cebpatm1Gonz/Cebpatm1Gonz
Tg(SFTPC-rtTA)5Jaw/0
Tg(tetO-cre)1Jaw/0
involves: 129 * 129X1/SvJ * C57BL/6 * FVB/N 		abnormal lung saccule morphology J:106543
abnormal lung vasculature morphology J:106543
abnormal surfactant secretion J:106543
abnormal type I pneumocyte morphology J:106543
abnormal type II pneumocyte morphology J:106543
absent type I pneumocytes J:106543
atelectasis J:106543
neonatal lethality, complete penetrance J:106543
pulmonary vascular congestion J:106543
respiratory distress J:106543
Cebpatm1Kgx/Cebpatm1Kgx
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 		abnormal bile canaliculus morphology J:35795
abnormal glucose homeostasis J:35795
abnormal hepatocyte morphology J:35795
abnormal lipid homeostasis J:35795, J:89611
abnormal liver morphology J:35795
abnormal lung development J:35795
abnormal lung interstitium morphology J:35795
abnormal pulmonary alveolus morphology J:35795
abnormal type II pneumocyte morphology J:35795
absent gastric milk in neonates J:35795
decreased birth weight J:35795
decreased body size J:35795
decreased brown adipose tissue amount J:35795
decreased liver glycogen level J:35795
decreased white adipose tissue amount J:89611
flaky skin J:35795
hypoglycemia J:35795
impaired lung alveolus development J:35795
increased litter size J:35795
increased type II pneumocyte number J:35795
lethargy J:35795
neonatal lethality, incomplete penetrance J:35795
postnatal growth retardation J:35795
postnatal lethality, incomplete penetrance J:35795
respiratory distress J:35795
respiratory failure J:35795
slow postnatal weight gain J:35795
Cebpatm1Nerl/Cebpatm1Nerl
involves: 129P2/OlaHsd * C57BL/6 		normal adipose tissue phenotype J:72330
normal immune system phenotype J:72330
no abnormal phenotype detected J:72330
Cebpatm1Timc/Cebpatm1Timc
Not Specified 		decreased circulating glucose level J:163725
decreased hepatocyte proliferation J:163725
hepatic steatosis J:163725
increased circulating alanine transaminase level J:163725
increased circulating aspartate transaminase level J:163725
increased circulating triglyceride level J:163725
increased incidence of tumors by chemical induction J:163725
Cebpatm2Btp/Cebpatm2Btp
B6.129P2-Cebpatm2Btp 		abnormal bone marrow cell morphology/development J:187834
abnormal definitive hematopoiesis J:187834
abnormal myelopoiesis J:187834
decreased neutrophil cell number J:187834
enlarged spleen J:187834
normal hematopoietic system phenotype J:187834
increased erythroid progenitor cell number J:187834
increased hematopoietic stem cell number J:187834
Cebpatm2Nerl/Cebpatm2Nerl
involves: 129P2/OlaHsd * C57BL/6 		abnormal gonadal fat pad morphology J:72330
abnormal granulocyte morphology J:72330
decreased granulocyte number J:72330
decreased white adipose tissue amount J:72330
normal immune system phenotype J:72330
premature death J:72330
Cebpatm3Nerl/Cebpatm3Nerl
involves: 129P2/OlaHsd * C57BL/6 		normal adipose tissue phenotype J:72330
normal immune system phenotype J:72330
Cebpatm4Nerl/Cebpatm4Nerl
involves: 129P2/OlaHsd * C57BL/6 		abnormal gonadal fat pad morphology J:72330
abnormal granulocyte morphology J:72330
decreased granulocyte number J:72330
decreased white adipose tissue amount J:72330
normal immune system phenotype J:72330
premature death J:72330
Cebpatm5Nerl/Cebpatm5Nerl
involves: 129P2/OlaHsd * C57BL/6 		abnormal hepatocyte morphology J:120098
abnormal liver physiology J:120098
normal adipose tissue phenotype J:120098
increased liver triglyceride level J:120098
normal liver/biliary system phenotype J:120098
Cebpatm6Nerl/Cebpatm6Nerl
involves: 129P2/OlaHsd * C57BL/6 		abnormal circulating insulin level J:120098
abnormal liver physiology J:120098
normal adipose tissue phenotype J:120098
decreased adipocyte glucose uptake J:120098
decreased liver glycogen level J:120098
decreased skeletal muscle cell glucose uptake J:120098
normal hematopoietic system phenotype J:120098
impaired glucose tolerance J:120098
increased circulating glucose level J:120098
normal respiratory system phenotype J:120098
Cebpatm8.1Nerl/Cebpa+
involves: 129P2/OlaHsd * BALB/cJ * C57BL/6 		abnormal common myeloid progenitor cell morphology J:136134
Cebpatm8.1Nerl/Cebpatm8.1Nerl
involves: 129P2/OlaHsd * BALB/cJ * C57BL/6 		abnormal common myeloid progenitor cell morphology J:136134
abnormal definitive hematopoiesis J:136134
abnormal granulocyte morphology J:136134
abnormal leukocyte morphology J:136134
abnormal myeloid leukocyte morphology J:136134
decreased granulocyte number J:136134
decreased hematocrit J:136134
decreased hepatocyte number J:136134
decreased monocyte cell number J:136134
decreased neutrophil cell number J:136134
enlarged spleen J:136134
extramedullary hematopoiesis J:136134
hypoglycemia J:136134
increased leukemia incidence J:136134
liver failure J:136134
liver inflammation J:136134
postnatal lethality, incomplete penetrance J:136134
premature death J:136134
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory