Cebpa Phenotype Annotations - Multigenic Genotypes

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Cebpa
CCAAT/enhancer binding protein alpha
MGI:99480

57 phenotypes from multigenic genotypes

Allelic Composition Genetic Background	Annotated Term	Reference
Cebpa^{tm1.1(Cebpb)Ylee}/Cebpa^{tm1.1(Cebpb)Ylee} involves: 129X1/SvJ * C57BL/6 * FVB/N	abnormal brown adipose tissue morphology	J:77646
	abnormal fat cell morphology	J:77646
	abnormal hematopoietic system physiology	J:77646
	abnormal white adipose tissue morphology	J:77646
	decreased circulating leptin level	J:77646
	decreased white adipose tissue amount	J:77646
	normal growth/size/body region phenotype	J:77646
	normal homeostasis/metabolism phenotype	J:77646
	normal immune system phenotype	J:77646
	increased brown adipose tissue amount	J:77646
	increased food intake	J:77646
	normal reproductive system phenotype	J:77646
Cebpa^{tm1.1(Cebpb)Ylee}/Cebpa^tm1.1Gonz involves: 129X1/SvJ * C57BL/6 * FVB/N	abnormal white adipose tissue morphology	J:77646
	decreased white adipose tissue amount	J:77646
Cebpa^tm1Gonz/Cebpa⁺ Cebpb^tm1Nerl/Cebpb^tm1Nerl Tg(KRT14-cre)1Cgn/0 involves: 129P2/OlaHsd * 129X1/SvJ * C57BL/6 * DBA/2	normal integument phenotype	J:154022
Cebpa^tm1Gonz/Cebpa^tm1Gonz Cebpb^tm1Es/Cebpb^tm1Es Tg(KRT14-cre/ERT)20Efu/0 involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CD-1	abnormal epidermal layer morphology	J:158721
	abnormal epidermis stratum basale morphology	J:158721
	abnormal epidermis stratum spinosum morphology	J:158721
	abnormal epidermis suprabasal layer morphology	J:158721
	abnormal eye morphology	J:158721
	abnormal hair follicle infundibulum morphology	J:158721
	abnormal keratinocyte differentiation	J:158721
	abnormal male preputial gland morphology	J:158721
	abnormal Meibomian gland morphology	J:158721
	abnormal sebaceous gland morphology	J:158721
	abnormal sebaceous lipid secretion	J:158721
	abnormal sebocyte differentiation	J:158721
	abnormal sebocyte morphology	J:158721
	dry eyes	J:158721
	epidermal hyperplasia	J:158721
	hair follicle outer root sheath hyperplasia	J:158721
	hyperkeratosis	J:158721
	increased keratinocyte proliferation	J:158721
	Meibomian gland atrophy	J:158721
	parakeratosis	J:158721
Cebpa^tm1Gonz/Cebpa^tm1Gonz Cebpb^tm1Nerl/Cebpb^tm1Nerl Tg(KRT14-cre)1Cgn/0 involves: 129P2/OlaHsd * 129X1/SvJ * C57BL/6 * DBA/2	abnormal epidermal layer morphology	J:154022
	eyelids open at birth	J:154022
	increased keratinocyte proliferation	J:154022
	neonatal lethality, complete penetrance	J:154022
	parakeratosis	J:154022
	shiny skin	J:154022
	tight skin	J:154022
	weight loss	J:154022
Cebpa^tm1Gonz/Cebpa^tm1Gonz Lep^ob/Lep^ob Tg(Alb1-cre)1Dlr/0 involves: 129X1/SvJ * C57BL/6J * FVB/N	abnormal fat cell morphology	J:93579
	abnormal lipid homeostasis	J:93579
	decreased circulating cholesterol level	J:93579
	decreased circulating HDL cholesterol level	J:93579
	decreased circulating insulin level	J:93579
	decreased circulating LDL cholesterol level	J:93579
	decreased liver cholesterol level	J:93579
	decreased liver triglyceride level	J:93579
	decreased susceptibility to diet-induced hepatic steatosis	J:93579
	decreased susceptibility to diet-induced obesity	J:93579
	impaired glucose tolerance	J:93579
	increased circulating free fatty acids level	J:93579
	increased circulating glucose level	J:93579
	increased circulating VLDL cholesterol level	J:93579
	increased liver glycogen level	J:93579
	insulin resistance	J:93579
Cebpa^tm1Gonz/Cebpa^tm2Nerl Cebpb^tm1Nerl/Cebpb^tm1Nerl Tg(KRT14-cre)1Cgn/0 involves: 129P2/OlaHsd * 129X1/SvJ * C57BL/6 * DBA/2	abnormal epidermis stratum corneum morphology	J:154022
	abnormal epidermis stratum granulosum morphology	J:154022
	increased keratinocyte proliferation	J:154022
	shiny skin	J:154022
Cebpa^tm1Gonz/Cebpa^tm9Nerl Cebpb^tm1Nerl/Cebpb^tm1Nerl Tg(KRT14-cre)1Cgn/0 involves: 129P2/OlaHsd * 129X1/SvJ * C57BL/6 * DBA/2	absent epidermis stratum corneum	J:154022
	absent epidermis stratum granulosum	J:154022
	increased keratinocyte proliferation	J:154022
	parakeratosis	J:154022
	shiny skin	J:154022

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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