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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Clcn5
chloride channel, voltage-sensitive 5
MGI:99486
26 phenotypes from 6 alleles in 6 genetic backgrounds
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Allelic Composition
Genetic Background		 Annotated Term Reference
Clcn5tm1Gug/Y
involves: 129S1/Sv * 129X1/SvJ * C57BL/6J 		abnormal kidney corticomedullary boundary morphology J:66560
abnormal renal protein reabsorption J:66560, J:84433
abnormal tooth development J:66560
aminoaciduria J:66560
cystinuria J:66560
hydroxyprolinuria J:66560
hyperglutaminuria J:66560
hyperthreoninuria J:66560
increased urine calcium level J:66560
increased urine glucose level J:66560
increased urine phosphate level J:66560
increased urine protein level J:66560
kyphosis J:66560
nephrocalcinosis J:66560
polyuria J:66560
normal renal/urinary system phenotype J:66560
Clcn5tm1Tjj/Y
B6.129-Clcn5tm1Tjj 		abnormal metabolism J:91340
abnormal renal transport J:77111, J:91340
decreased urine pH J:77111
increased urine beta2-microglobulin level J:77111
increased urine phosphate level J:77111
increased urine protein level J:77111
normal liver/biliary system phenotype J:77111
polyuria J:77111
normal renal/urinary system phenotype J:77111
Clcn5tm1Tjj/Y
involves: 129 		abnormal cell physiology J:160701
decreased urine pH J:160701
increased urine calcium level J:160701
increased urine glucose level J:160701
increased urine insulin level J:160701
increased urine phosphate level J:160701
Clcn5tm2.1Tjj/Y
involves: 129P2/OlaHsd * 129X1/SvJ * BALB/cJ * C57BL/6 		abnormal cell physiology J:160701
decreased urine creatinine level J:160701
decreased urine pH J:160701
increased urine calcium level J:160701
increased urine glucose level J:160701
increased urine insulin level J:160701
increased urine phosphate level J:160701
increased urine protein level J:160701
polyuria J:160701
Clcn5tm3.1Tjj/Y
involves: 129S1/Sv * 129S4/SvJaeSor * 129X1/SvJ * C57BL/6 		normal cellular phenotype J:160701
Clcn5tm4.1Tjj/Y
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 		no abnormal phenotype detected J:164474
Clcn5tm5.1Tjj/Clcn5+
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 		normal renal/urinary system phenotype J:164474
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory