Cd19tm1(cre)Cgn/Cd19+ Ptpn11tm1Ckq/Ptpn11+
involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6J
|
increased acute lymphoblastic leukemia incidence |
J:177285
|
increased B cell derived lymphoma incidence |
J:177285
|
premature death |
J:177285
|
Egr2tm2(cre)Pch/Egr2+ Ptpn11tm1.1Wbm/Ptpn11tm1.1Wbm
involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6 * SJL
|
abnormal myelination |
J:153219,
J:207470
|
decreased motor neuron number |
J:153219
|
decreased nerve conduction velocity |
J:153219
|
Emx1tm1(cre)Krj/Emx1+ Ptpn11tm6Bgn/Ptpn11+
B6.129S-Ptpn11tm6Bgn Emx1tm1(cre)Krj
|
abnormal hippocampus neuron morphology |
J:242312
|
abnormal spatial learning |
J:242312
|
decreased exploration in new environment |
J:242312
|
impaired cued conditioning behavior |
J:242312
|
Hprt1tm1(CAG-cre)Mnn/Hprt1+ Ptpn11tm1Ckq/Ptpn11+
involves: 129S1/Sv * 129S6/SvEvTac * C57BL/6J
|
abnormal craniofacial development |
J:177285
|
abnormal heart tube morphology |
J:177285
|
embryonic growth retardation |
J:177285
|
embryonic lethality during organogenesis, complete penetrance |
J:177285
|
Meox2tm1(cre)Sor/Meox2+ Ptpn11tm6Bgn/Ptpn11+
involves: 129S4/SvJaeSor * 129S6/SvEvTac * C57BL/6
|
abnormal heart morphology |
J:147154
|
atrial septal defect |
J:147154
|
double outlet right ventricle |
J:147154
|
heart valve hyperplasia |
J:147154
|
thin myocardium |
J:147154
|
ventricular septal defect |
J:147154
|
Ptpn11tm1.1Ics/Ptpn11+
involves: 129S2/SvPas * C57BL/6 * FVB/N
|
abnormal carbohydrate metabolism |
J:216593
|
abnormal cranium size |
J:216593
|
abnormal epididymal fat pad morphology |
J:216593
|
abnormal fat cell differentiation |
J:216593
|
abnormal heart septum morphology |
J:216593
|
abnormal lipid level |
J:216593
|
cardiac hypertrophy |
J:216593
|
decreased brown adipose tissue amount |
J:216593
|
decreased cardiac muscle contractility |
J:216593
|
decreased cardiac stroke volume |
J:216593
|
decreased circulating adiponectin level |
J:216593
|
decreased circulating alanine transaminase level |
J:216593
|
decreased circulating glucose level |
J:216593
|
decreased circulating insulin level |
J:216593
|
decreased circulating leptin level |
J:216593
|
decreased cranium length |
J:216593
|
decreased heart left ventricle posterior wall thickness |
J:216593
|
decreased heart rate |
J:216593
|
decreased liver triglyceride level |
J:216593
|
decreased skeletal muscle triglyceride level |
J:216593
|
decreased subcutaneous adipose tissue amount |
J:216593
|
decreased susceptibility to diet-induced obesity |
J:216593
|
decreased systemic arterial blood pressure |
J:216593
|
decreased total body fat amount |
J:216593
|
decreased white fat cell number |
J:216593
|
dilated cardiomyopathy |
J:216593
|
dilated heart left ventricle |
J:216593
|
enhanced lipolysis |
J:216593
|
enlarged heart |
J:216593
|
enlarged spleen |
J:216593
|
heart left ventricle hypertrophy |
J:216593
|
improved glucose tolerance |
J:216593
|
increased adipocyte glucose uptake |
J:216593
|
increased energy expenditure |
J:216593
|
increased fat cell size |
J:216593
|
increased glycerol level |
J:216593
|
increased insulin sensitivity |
J:216593
|
increased lean body mass |
J:216593
|
ocular hypertelorism |
J:216593
|
postnatal growth retardation |
J:216593
|
slow postnatal weight gain |
J:216593
|
Ptpn11tm1.1Rbns/Ptpn11tm1.1Rbns
B6.Cg-Ptpn11tm1.1Rbns
|
no abnormal phenotype detected |
J:150835
|
Ptpn11tm1.1Rbns/Ptpn11tm1.1Rbns H2az2Tg(Wnt1-cre)11Rth/H2az2+
B6.Cg-Ptpn11tm1.1Rbns H2az2Tg(Wnt1-cre)11Rth
|
abnormal aortic arch and aortic arch branch attachment |
J:150835
|
abnormal eye distance/ position |
J:150835
|
abnormal mandible morphology |
J:150835
|
abnormal nasal bone morphology |
J:150835
|
abnormal nasal cartilage morphology |
J:150835
|
abnormal nasopharynx morphology |
J:150835
|
abnormal tongue morphology |
J:150835
|
absent craniofacial bones |
J:150835
|
absent mandible |
J:150835
|
absent nasal capsule |
J:150835
|
common truncal valve |
J:150835
|
decreased fetal size |
J:150835
|
lethality throughout fetal growth and development, complete penetrance |
J:150835
|
microcephaly |
J:150835
|
micrognathia |
J:150835
|
persistent truncus arteriosus |
J:150835
|
small ears |
J:150835
|
small snout |
J:150835
|
ventricular septal defect |
J:150835
|
Ptpn11tm1.1Wbm/Ptpn11tm1.1Wbm
involves: 129P2/OlaHsd * C57BL/6 * SJL
|
abnormal Schwann cell physiology |
J:153219
|
Ptpn11tm1.1Wbm/Ptpn11tm1.1Wbm H2az2Tg(Wnt1-cre)11Rth/H2az2+
involves: 129P2/OlaHsd * C57BL/6 * C57BL/6J * SJL * SJL/J
|
abnormal axon extension |
J:153219
|
abnormal axon fasciculation |
J:153219
|
abnormal craniofacial morphology |
J:153219
|
abnormal melanocyte morphology |
J:153219
|
abnormal sensory neuron innervation pattern |
J:153219
|
absent Schwann cell precursors |
J:153219
|
decreased enteric neural crest cell number |
J:153219
|
decreased Schwann cell number |
J:153219
|
decreased Schwann cell precursor number |
J:153219
|
decreased sensory neuron number |
J:153219
|
embryonic lethality during organogenesis, incomplete penetrance |
J:153219
|
Ptpn11tm1.1Wbm/Ptpn11tm1.1Wbm Tg(Dhh-cre)1Mejr/0
involves: 129P2/OlaHsd * FVB/N
|
abnormal Schwann cell physiology |
J:207470
|
decreased Schwann cell number |
J:207470
|
Ptpn11tm1Bgn/Ptpn11+
129S6.129S4-Ptpn11tm1Bgn
|
normal
mortality/aging |
J:147154
|
Ptpn11tm1Bgn/Ptpn11+
B6.129S4-Ptpn11tm1Bgn
|
abnormal heart morphology |
J:147154
|
perinatal lethality, incomplete penetrance |
J:147154
|
Ptpn11tm1Bgn/Ptpn11+
C.129S4-Ptpn11tm1Bgn
|
perinatal lethality, incomplete penetrance |
J:147154
|
Ptpn11tm1Bgn/Ptpn11+
involves: 129S4/SvJae * C57BL/6
|
abnormal cardiac epithelial to mesenchymal transition |
J:147154
|
abnormal common myeloid progenitor cell morphology |
J:147154
|
decreased body length |
J:147154
|
decreased body weight |
J:147154
|
increased inner canthal distance |
J:147154
|
perinatal lethality, incomplete penetrance |
J:147154
|
Ptpn11tm1Bgn/Ptpn11+
involves: 129S4/SvJae * C57BL/6J
|
abnormal heart development |
J:91609
|
broad snout |
J:91609
|
decreased body length |
J:91609
|
decreased body weight |
J:91609
|
decreased cardiomyocyte apoptosis |
J:91609
|
double outlet right ventricle |
J:91609
|
enlarged mitral valve |
J:91609
|
enlarged spleen |
J:91609
|
flattened snout |
J:91609
|
hepatic necrosis |
J:91609
|
increased cell proliferation |
J:91609
|
increased leukocyte cell number |
J:91609
|
increased lymphocyte cell number |
J:91609
|
increased neutrophil cell number |
J:91609
|
myeloid hyperplasia |
J:91609
|
perinatal lethality, incomplete penetrance |
J:91609
|
small cranium |
J:91609
|
ventricular septal defect |
J:91609
|
Ptpn11tm1Bgn/Ptpn11tm1Bgn
involves: 129S4/SvJae * C57BL/6J
|
abnormal heart development |
J:91609
|
atrial septal defect |
J:91609
|
atrioventricular septal defect |
J:91609
|
decreased cardiomyocyte apoptosis |
J:91609
|
double outlet right ventricle |
J:91609
|
embryonic lethality during organogenesis, complete penetrance |
J:91609
|
hemorrhage |
J:91609
|
hepatic necrosis |
J:91609
|
hydrops fetalis |
J:91609
|
increased cell proliferation |
J:91609
|
pericardial effusion |
J:91609
|
small liver |
J:91609
|
thin myocardium |
J:91609
|
thin myocardium compact layer |
J:91609
|
ventricular septal defect |
J:91609
|
Ptpn11tm1Ckq/Ptpn11+
involves: 129S6/SvEvTac * C57BL/6J
|
no abnormal phenotype detected |
J:177285
|
Ptpn11tm1Ckq/Ptpn11+ Lyz2tm1(cre)Ifo/Lyz2+
involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6J
|
increased acute promyelocytic leukemia incidence |
J:177285
|
myeloid hyperplasia |
J:177285
|
premature death |
J:177285
|
Ptpn11tm1Ckq/Ptpn11+ Tg(Mx1-cre)1Cgn/0
involves: 129S6/SvEvTac * C57BL/6 * C57BL/6J * CBA
|
abnormal bone marrow cell morphology/development |
J:177285
|
abnormal hematopoietic stem cell physiology |
J:177285
|
anemia |
J:177285
|
aneuploidy |
J:177285
|
arrested B cell differentiation |
J:177285
|
chromosomal instability |
J:177285
|
decreased common myeloid progenitor cell number |
J:177285
|
decreased hematopoietic stem cell number |
J:177285
|
enlarged liver |
J:177285
|
enlarged spleen |
J:177285
|
extramedullary hematopoiesis |
J:177285
|
increased acute lymphoblastic leukemia incidence |
J:177285
|
increased acute promyelocytic leukemia incidence |
J:177285
|
increased B cell derived lymphoma incidence |
J:177285
|
increased hematopoietic stem cell number |
J:177285
|
increased leukemia incidence |
J:177285
|
increased leukocyte cell number |
J:177285
|
increased lymphoblastic lymphoma incidence |
J:177285
|
increased neutrophil cell number |
J:177285
|
increased spleen weight |
J:177285
|
myeloid hyperplasia |
J:177285
|
premature death |
J:177285
|
Ptpn11tm1Ckq/Ptpn11+ Tg(Lck-cre)1Cwi/0
involves: 129S6/SvEvTac * C57BL/6J
|
normal
immune system phenotype |
J:177285
|
increased acute lymphoblastic leukemia incidence |
J:177285
|
increased lymphoblastic lymphoma incidence |
J:177285
|
premature death |
J:177285
|
Ptpn11tm1Gsf/Ptpn11tm1Gsf Plekha5Tg(AMH-cre)1Flor/Plekha5+
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL
|
abnormal seminiferous tubule epithelium morphology |
J:250152
|
abnormal Sertoli cell barrier function |
J:250152
|
abnormal Sertoli cell barrier morphology |
J:250152
|
abnormal spermatocyte morphology |
J:250152
|
abnormal spermatogonia morphology |
J:250152
|
arrest of spermatogenesis |
J:250152
|
azoospermia |
J:250152
|
decreased male germ cell number |
J:250152
|
decreased testis weight |
J:250152
|
increased Leydig cell number |
J:250152
|
increased male germ cell apoptosis |
J:250152
|
male infertility |
J:250152
|
seminiferous tubule degeneration |
J:250152
|
small seminiferous tubules |
J:250152
|
Ptpn11tm1Gsf/Ptpn11tm1Gsf Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * DBA
|
abnormal hepatocyte morphology |
J:172422
|
abnormal liver morphology |
J:172422
|
abnormal liver parenchyma morphology |
J:172422
|
focal hepatic necrosis |
J:172422
|
hepatic necrosis |
J:172422
|
increased acute inflammation |
J:172422
|
increased circulating alanine transaminase level |
J:172422
|
increased circulating aspartate transaminase level |
J:172422
|
increased circulating interleukin-6 level |
J:172422
|
increased hepatocyte proliferation |
J:172422
|
increased incidence of tumors by chemical induction |
J:172422
|
increased liver adenoma incidence |
J:172422
|
liver fibrosis |
J:172422
|
liver hyperplasia |
J:172422
|
liver inflammation |
J:172422
|
weight loss |
J:172422
|
Ptpn11tm1Gsf/Ptpn11tm1Gsf Tg(Camk2a-cre)2Szi/0
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA
|
abnormal circulating hormone level |
J:94738
|
abnormal glucose homeostasis |
J:94738
|
abnormal liver morphology |
J:94738
|
decreased body temperature |
J:94738
|
decreased circulating thyroxine level |
J:94738
|
decreased circulating triiodothyronine level |
J:94738
|
enlarged liver |
J:94738
|
hepatic steatosis |
J:94738
|
hyperglycemia |
J:94738
|
hypersecretion of corticosterone |
J:94738
|
hypoglycemia |
J:94738
|
increased body length |
J:94738
|
increased brown adipose tissue amount |
J:94738
|
increased circulating corticosterone level |
J:94738
|
increased circulating growth hormone level |
J:94738
|
increased circulating insulin level |
J:94738
|
increased circulating leptin level |
J:94738
|
increased circulating thyroid-stimulating hormone level |
J:94738
|
increased circulating triglyceride level |
J:94738
|
increased liver glycogen level |
J:94738
|
increased liver triglyceride level |
J:94738
|
increased susceptibility to weight gain |
J:94738
|
increased white adipose tissue amount |
J:94738
|
obese |
J:94738
|
reduced female fertility |
J:94738
|
Ptpn11tm1Gsf/Ptpn11tm1Gsf Tg(Ckmm-cre)5Khn/0
involves: 129S1/Sv * 129X1/SvJ * FVB
|
abnormal heart echocardiography feature |
J:144767
|
abnormal myocardial fiber calcium currents |
J:144767
|
congestive heart failure |
J:144767
|
decreased cardiac muscle cell glucose uptake |
J:144767
|
decreased heart left ventricle muscle contractility |
J:144767
|
decreased skeletal muscle cell glucose uptake |
J:144767
|
dilated cardiomyopathy |
J:144767
|
enlarged heart |
J:144767
|
impaired glucose tolerance |
J:144767
|
increased cardiac muscle triglyceride level |
J:144767
|
increased circulating insulin level |
J:144767
|
increased circulating triglyceride level |
J:144767
|
increased heart ventricle size |
J:144767
|
increased myocardial fiber size |
J:144767
|
increased skeletal muscle triglyceride level |
J:144767
|
insulin resistance |
J:144767
|
premature death |
J:144767
|
Ptpn11tm1Gsf/Ptpn11tm1Gsf Tg(Col2a1-cre/ERT2)1Dic/0
involves: 129S1/Sv * 129X1/SvJ * C57BL/6
|
abnormal gait |
J:324822
|
abnormal spine curvature |
J:324822
|
abnormal vertebral column morphology |
J:324822
|
abnormal vertebral epiphyseal plate morphology |
J:324822
|
ectopic cartilage |
J:233244
|
exostosis |
J:233244
|
kyphoscoliosis |
J:324822
|
kyphosis |
J:324822
|
lordosis |
J:324822
|
scoliosis |
J:324822
|
normal
skeleton phenotype |
J:324822
|
Ptpn11tm1Gsf/Ptpn11tm1Gsf Tg(Inha-cre)3Zuk/0
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL
|
arrest of spermatogenesis |
J:250152
|
male infertility |
J:250152
|
seminiferous tubule degeneration |
J:250152
|
small testis |
J:250152
|
Ptpn11tm1Gsf/Ptpn11tm1Gsf Tg(Pax6-cre,GFP)1Pgr/0
involves: 129S1/Sv * 129X1/SvJ * FVB
|
abnormal lacrimal gland development |
J:130571
|
absent lacrimal glands |
J:130571
|
Ptpn11tm1Gsf/Ptpn11tm1Gsf Tg(Six3-cre)69Frty/0
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * DBA/2
|
abnormal cone electrophysiology |
J:174095
|
abnormal retina inner nuclear layer morphology |
J:174095
|
abnormal rod electrophysiology |
J:174095
|
decreased a-wave amplitude |
J:174095
|
decreased b-wave amplitude |
J:174095
|
optic nerve atrophy |
J:174095
|
retina degeneration |
J:174095
|
retina ganglion cell degeneration |
J:174095
|
retina outer nuclear layer degeneration |
J:174095
|
thin retina ganglion layer |
J:174095
|
thin retina inner nuclear layer |
J:174095
|
thin retina inner plexiform layer |
J:174095
|
thin retina outer nuclear layer |
J:174095
|
Ptpn11tm1Paw/Ptpn11tm1Paw
involves: 129S1/Sv * 129X1/SvJ
|
abnormal cell death |
J:106624
|
decreased cell proliferation |
J:106624
|
polyploidy |
J:106624
|
Ptpn11tm1Paw/Ptpn11tm1Paw
involves: 129S1/Sv * 129X1/SvJ * CD-1
|
abnormal allantois morphology |
J:43740
|
abnormal axial mesoderm morphology |
J:43740
|
abnormal embryonic neuroepithelium morphology |
J:43740
|
abnormal gastrulation |
J:43740
|
abnormal heart development |
J:43740
|
abnormal neural tube morphology |
J:43740
|
abnormal notochord morphology |
J:43740
|
abnormal rostral-caudal axis patterning |
J:43740
|
abnormal visceral yolk sac morphology |
J:43740
|
abnormal vitelline vascular remodeling |
J:43740
|
caudal body truncation |
J:43740
|
embryonic growth arrest |
J:43740
|
embryonic growth retardation |
J:43740
|
embryonic lethality during organogenesis, complete penetrance |
J:43740
|
failure of initiation of embryo turning |
J:43740
|
incomplete somite formation |
J:43740
|
kinked neural tube |
J:43740
|
open neural tube |
J:43740
|
Ptpn11tm1Rbn/Ptpn11+
involves: 129 * Black Swiss
|
no abnormal phenotype detected |
J:35137
|
Ptpn11tm1Rbn/Ptpn11tm1Rbn
involves: 129 * Black Swiss
|
decreased litter size |
J:35137
|
embryonic lethality, complete penetrance |
J:35137
|
Ptpn11tm1Yan/Ptpn11tm1Yan Tg(Ckmm-cre)5Khn/0
involves: 129/Sv * C57BL/6 * FVB
|
decreased skeletal muscle fiber number |
J:114499
|
decreased skeletal muscle fiber size |
J:114499
|
Ptpn11tm2Bgn/Ptpn11tm2Bgn
involves: 129S4/SvJae
|
disorganized embryonic tissue |
J:106624
|
embryonic lethality between implantation and somite formation, complete penetrance |
J:106624
|
inner cell mass degeneration |
J:106624
|
Ptpn11tm3Bgn/Ptpn11tm3Bgn
involves: 129X1/SvJ * C57BL/6J
|
improved glucose tolerance |
J:167406
|
Ptpn11tm3Bgn/Ptpn11tm3Bgn Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
involves: 129X1/SvJ * C57BL/6 * C57BL/6J * DBA
|
decreased circulating glucose level |
J:167406
|
decreased circulating insulin level |
J:167406
|
decreased circulating triglyceride level |
J:167406
|
improved glucose tolerance |
J:167406
|
increased insulin sensitivity |
J:167406
|
Ptpn11tm4.2Bgn/Ptpn11+
B6.129S6-Ptpn11tm4.2Bgn
|
abnormal interventricular septum morphology |
J:301775
|
cardiac fibrosis |
J:301775
|
increased heart weight |
J:301775
|
thick ventricular wall |
J:301775
|
Ptpn11tm4.2Bgn/Ptpn11+
involves: 129S6/SvEvTac * C57BL/6J * FVB/N
|
abnormal chest morphology |
J:172033
|
abnormal cranium size |
J:172033
|
abnormal eye distance/ position |
J:172033
|
abnormal facial morphology |
J:172033
|
abnormal organ of Corti morphology |
J:172033
|
abnormal reproductive system morphology |
J:172033
|
cardiac fibrosis |
J:172033
|
cardiac hypertrophy |
J:172033
|
normal
cardiovascular system phenotype |
J:172033
|
decreased body size |
J:172033
|
decreased heart ventricle muscle contractility |
J:172033
|
depressed nasal bridge |
J:172033
|
dilated cardiomyopathy |
J:172033
|
enlarged heart |
J:172033
|
heart left ventricle hypertrophy |
J:172033
|
normal
hematopoietic system phenotype |
J:172033
|
increased heart weight |
J:172033
|
increased myocardial fiber size |
J:172033
|
ocular hypertelorism |
J:172033
|
pectus carinatum |
J:172033
|
pectus excavatum |
J:172033
|
premature death |
J:172033
|
short femur |
J:172033
|
thick interventricular septum |
J:172033
|
thick ventricular wall |
J:172033
|
Ptpn11tm5Bgn/Ptpn11tm5Bgn
involves: 129S4/SvJae * C57BL/6J
|
abnormal blastocyst morphology |
J:106624
|
abnormal endoderm development |
J:106624
|
abnormal trophectoderm morphology |
J:106624
|
decreased trophectoderm cell proliferation |
J:106624
|
embryonic lethality at implantation, incomplete penetrance |
J:106624
|
impaired embryo implantation |
J:106624
|
Ptpn11tm6Bgn/Ptpn11+ Tg(Tek-cre)12Flv/0
involves: 129S6/SvEvTac * C3H * C57BL/6
|
double outlet right ventricle |
J:147154
|
embryonic lethality |
J:147154
|
increased atrioventricular cushion size |
J:147154
|
thin myocardium |
J:147154
|
ventricular septal defect |
J:147154
|
Ptpn11tm6Bgn/Ptpn11+ Tg(EIIa-cre)C5379Lmgd/0
involves: 129S6/SvEvTac * FVB/N
|
preweaning lethality, complete penetrance |
J:148430
|
Ptpn11tm6Bgn/Ptpn11+ Tg(Mx1-cre)1Cgn/0
involves: 129S6/SvEvTac * C57BL/6 * CBA
|
abnormal bone marrow cell number |
J:148430
|
abnormal definitive hematopoiesis |
J:148430
|
abnormal erythropoiesis |
J:148430
|
abnormal leukopoiesis |
J:148430
|
abnormal liver sinusoid morphology |
J:148430
|
abnormal splenic cell ratio |
J:148430
|
anemia |
J:148430
|
decreased bone marrow cell number |
J:148430
|
decreased common myeloid progenitor cell number |
J:148430
|
decreased granulocyte monocyte progenitor cell number |
J:148430
|
decreased hematopoietic stem cell number |
J:148430
|
enlarged liver |
J:148430
|
enlarged spleen |
J:148430
|
extramedullary hematopoiesis |
J:148430
|
increased granulocyte number |
J:148430
|
increased leukocyte cell number |
J:148430
|
increased monocyte cell number |
J:148430
|
intermingled spleen red and white pulp |
J:148430
|
premature death |
J:148430
|
Ptpn11tm6Bgn/Ptpn11+ Tg(CAG-cre/Esr1*)5Amc/0
involves: 129S6/SvEvTac * C57BL/6 * CBA
|
abnormal definitive hematopoiesis |
J:148430
|
abnormal leukopoiesis |
J:148430
|
Ptpn11tm6Bgn/Ptpn11+ H2az2Tg(Wnt1-cre)11Rth/H2az2+
involves: 129S6/SvEvTac * C57BL/6 * CBA/J
|
normal
cardiovascular system phenotype |
J:147154
|
decreased cranium height |
J:147154
|
increased inner canthal distance |
J:147154
|
Ptpn11tm6Bgn/Ptpn11+ Tg(Myh6-cre)2182Mds/0
involves: 129S6/SvEvTac * C57BL/6 * FVB/N
|
normal
cardiovascular system phenotype |
J:147154
|
Ptpn11tm7Bgn/Ptpn11+
involves: 129S4/SvJae * 129S6/SvEvTac * C57BL/6
|
abnormal common myeloid progenitor cell morphology |
J:147154
|
decreased body length |
J:147154
|
decreased body weight |
J:147154
|
decreased cranium height |
J:147154
|
Ptpn11tm7Bgn/Ptpn11tm7Bgn
involves: 129S4/SvJae * 129S6/SvEvTac * C57BL/6
|
abnormal common myeloid progenitor cell morphology |
J:147154
|
atrial septal defect |
J:147154
|
decreased body length |
J:147154
|
decreased body weight |
J:147154
|
decreased cranium height |
J:147154
|
decreased survivor rate |
J:147154
|
double outlet right ventricle |
J:147154
|
increased atrioventricular cushion size |
J:147154
|
increased inner canthal distance |
J:147154
|
thin myocardium |
J:147154
|
ventricular septal defect |
J:147154
|
Tg(CAG-cat,-Ptpn11)1Rbns/0 Tg(Tek-cre)12Flv/0
involves: C3H * C57BL/6 * FVB/N
|
normal
cardiovascular system phenotype |
J:142212
|
Tg(Myh6-Ptpn11)75Rbns/0
FVB.Cg-Tg(Myh6-Ptpn11)75Rbns
|
normal
cardiovascular system phenotype |
J:123963
|
Tg(Myh6-Ptpn11*Q79R)197Rbns/0
FVB.Cg-Tg(Myh6-Ptpn11*Q79R)197Rbns
|
normal
cardiovascular system phenotype |
J:123963
|
Tg(Myh6-Ptpn11*Q510E)#Krnz/0
FVB/N-Tg(Myh6-Ptpn11*Q510E)#Krnz
|
normal
cardiovascular system phenotype |
J:181656
|
Tg(Myh7-Ptpn11)294Rbns/0
FVB.Cg-Tg(Myh7-Ptpn11)294Rbns
|
normal
cardiovascular system phenotype |
J:123963
|
Tg(Myh7-Ptpn11*Q79R)11Rbns/0
FVB.Cg-Tg(Myh7-Ptpn11*Q79R)11Rbns
|
abnormal atrial thrombosis |
J:123963
|
abnormal cardiovascular system physiology |
J:123963
|
abnormal interventricular groove morphology |
J:123963
|
decreased cardiac muscle contractility |
J:123963
|
dilated heart atrium |
J:123963
|
dilated heart ventricle |
J:123963
|
increased heart weight |
J:123963
|
increased lung weight |
J:123963
|
premature death |
J:123963
|
thick ventricular wall |
J:123963
|
ventricular cardiomyopathy |
J:123963
|
ventricular septal defect |
J:123963
|
Tg(Myh7-Ptpn11*Q510E)#Krnz/0
FVB/N-Tg(Myh7-Ptpn11*Q510E)#Krnz
|
abnormal heart echocardiography feature |
J:181656,
J:222124
|
abnormal heart ventricle shape |
J:181656
|
abnormal interventricular groove morphology |
J:181656
|
abnormal myocardial fiber morphology |
J:222124
|
abnormal myocardial fiber physiology |
J:222124
|
cardiac hypertrophy |
J:181656,
J:222124
|
cardiac interstitial fibrosis |
J:181656
|
cardiomyopathy |
J:181656
|
decreased heart left ventricle muscle contractility |
J:181656
|
fetal cardiomyocyte disarray |
J:181656
|
increased cardiac muscle contractility |
J:222124
|
increased fetal cardiomyocyte size |
J:181656
|
increased heart atrium size |
J:181656
|
increased heart left atrium size |
J:181656
|
increased heart weight |
J:181656,
J:222124
|
increased myocardial fiber size |
J:181656,
J:222124
|
myocardial fiber disarray |
J:181656
|
thick interventricular septum |
J:181656
|
ventricular septal defect |
J:181656
|