About   Help   FAQ
Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Syk
spleen tyrosine kinase
MGI:99515
53 phenotypes from 8 alleles in 16 genetic backgrounds
Export: Excel File
Allelic Composition
Genetic Background		 Annotated Term Reference
Sykm1Btlr/Sykm1Btlr
involves: C57BL/6J 		decreased B cell number J:199281
increased neutrophil cell number J:199281
increased tumor necrosis factor secretion J:199281
SykM2Btlr/Syk+
C57BL/6J-SykM2Btlr 		abnormal NK cell differentiation J:231803
decreased inflammatory response J:231803
SykM2Btlr/SykM2Btlr
C57BL/6J-SykM2Btlr 		abnormal NK cell differentiation J:231803
decreased inflammatory response J:231803
Syktm1.1Nns/Syktm1.1Nns
Commd10Tg(Vav1-icre)A2Kio/Commd10+
involves: C57BL/10 * CBA/Ca 		abnormal blood vessel morphology J:181715
abnormal lymphatic vessel morphology J:181715
edema J:181715
normal mortality/aging J:181715
Syktm1.1Nns/Syktm1.1Nns
Lyz2tm1(cre)Ifo/Lyz2+
involves: 129P2/OlaHsd 		normal homeostasis/metabolism phenotype J:181715
normal immune system phenotype J:181715
normal mortality/aging J:181715
Syktm1.1Nns/Syktm1.1Nns
Tg(CD2-icre)4Kio/0
involves: C57BL/10 * CBA/Ca 		normal homeostasis/metabolism phenotype J:181715
normal immune system phenotype J:181715
normal mortality/aging J:181715
Syktm1.1Nns/Syktm1.1Nns
Tg(Pf4-icre)Q3Rsko/0
involves: C57BL/6 		abnormal blood vessel morphology J:181715
abnormal lymphatic vessel endothelial cell morphology J:181715
abnormal lymphatic vessel morphology J:181715
abnormal platelet physiology J:181715
ascites J:181715
edema J:181715
intracranial hemorrhage J:181715
normal respiratory system phenotype J:181715
Syktm1.1Nns/Syktm1.1Nns
Tg(Tie1-cre)9Ref/0
Commd10Tg(Vav1-icre)A2Kio/Commd10+
involves: 129S1/Sv * 129X1/SvJ * C57BL/10 * CBA/Ca 		abnormal lymphatic vessel morphology J:181715
normal mortality/aging J:181715
Syktm1.1Tara/Syktm1.1Tara
involves: 129P2/OlaHsd * C57BL/6 		arrested B cell differentiation J:115080
increased B cell proliferation J:114816
perinatal lethality, incomplete penetrance J:115080
Syktm1.2Tara/Syktm1.2Tara
Tg(Cr2-cre)3Cgn/0
involves: 129P2/OlaHsd 		abnormal B cell morphology J:208904
Syktm1.2Tara/Syktm1.2Tara
Tg(Itgax-cre)1-1Reiz/0
involves: 129P2/OlaHsd * C57BL/6 * CBA 		normal homeostasis/metabolism phenotype J:181715
normal immune system phenotype J:181715
normal mortality/aging J:181715
Syktm1b(EUCOMM)Hmgu/Syk+
C57BL/6N-Syktm1b(EUCOMM)Hmgu/Ieg 		decreased exploration in new environment J:211773
decreased grip strength J:211773
decreased lean body mass J:211773
increased total body fat amount J:211773
Syktm1b(EUCOMM)Hmgu/Syktm1b(EUCOMM)Hmgu
C57BL/6N-Syktm1b(EUCOMM)Hmgu/Ieg 		preweaning lethality, complete penetrance J:211773
Syktm1Paw/Syktm1Paw
involves: 129S1/Sv * 129X1/SvJ 		abnormal B cell differentiation J:29797
abnormal blood vessel morphology J:159112
abnormal foot pad morphology J:29797
abnormal lymphangiogenesis J:159112
abnormal lymphatic vessel endothelium morphology J:159112
abnormal lymphatic vessel morphology J:159112
absent pre-B cells J:29797
decreased late pro-B cell number J:29797
dilated vasculature J:159112
enlarged lymphatic vessel J:159112
hemorrhage J:29797
hydrops fetalis J:29797
intracerebral hemorrhage J:159112
lymphatic vessel hyperplasia J:159112
postnatal lethality, complete penetrance J:29797
Syktm1Tyb/Syktm1.2Tara
Lyz2tm1(cre)Ifo/Lyz2+
involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6 		abnormal neutrophil physiology J:155479
impaired granulocyte bactericidal activity J:155479
Syktm1Tyb/Syktm1.2Tara
Tg(S100A8-cre,-EGFP)1Ilw/0
involves: 129P2/OlaHsd * 129S2/SvPas * C3H * C57BL/6 		impaired granulocyte bactericidal activity J:155479
Syktm1Tyb/Syktm1Tyb
involves: 129S2/SvPas 		abnormal dendritic cell antigen presentation J:147472
abnormal neutrophil physiology J:155479
decreased tumor necrosis factor secretion J:155479
impaired granulocyte bactericidal activity J:155479
impaired neutrophil phagocytosis J:155479
Syktm1Tyb/Syktm1Tyb
involves: 129S2/SvPas * C57BL/6 		abnormal osteoclast differentiation J:89583
decreased bone resorption J:89583
Syktm1Tyb/Syktm1Tyb
involves: 129S2/SvPas * C57BL/6 * DBA/2 		abnormal T cell number J:29796
arrested B cell differentiation J:29796
chylous ascites J:29796
hemorrhage J:29796
neonatal lethality, incomplete penetrance J:29796
postnatal lethality, complete penetrance J:29796
Syktm1Tyb/Syktm1Tyb
involves: 129S2/SvPas * C57BL/6J 		abnormal brain vasculature morphology J:181715
abnormal lung morphology J:181715
abnormal lymphatic vessel morphology J:181715
decreased lymphatic vessel endothelial cell number J:181715
intracranial hemorrhage J:181715
primary atelectasis J:181715
spinal hemorrhage J:181715
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
10/29/2024
MGI 6.24 		The Jackson Laboratory