About   Help   FAQ
Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Syk
spleen tyrosine kinase
MGI:99515
41 phenotypes from multigenic genotypes
Export: Excel File
Allelic Composition
Genetic Background		 Annotated Term Reference
Itgamtm1Myd/Itgamtm1Myd
Syktm1Tyb/Syktm1.2Tara
Lyz2tm1(cre)Ifo/Lyz2+
involves: 129P2/OlaHsd * 129S2/SvPas * 129S4/SvJae * C57BL/6 		impaired granulocyte bactericidal activity J:155479
Syktm1.1(cre)Fkfr/Syktm1.1(cre)Fkfr
Gt(ROSA)26Sortm1(EYFP)Cos/Gt(ROSA)26Sortm1(EYFP)Cos
involves: 129S1/Sv * 129X1/SvJ 		abnormal blood vessel morphology J:159112
abnormal liver development J:159112
abnormal lymphangiogenesis J:159112
decreased leukocyte cell number J:159112
decreased liver weight J:159112
increased leukocyte cell number J:159112
liver hypoplasia J:159112
Syktm1Kuro/Syktm1Kuro
Zap70tm1Dlo/Zap70tm1Dlo
Cd79atm1(cre)Reth/?
involves: 129P2/OlaHsd * BALB/c * C57BL/6 		abnormal pro-B cell differentiation J:134528
Syktm2.1(ZAP70)Fkfr/Syktm2.1(ZAP70)Fkfr
B6.129-Syktm2.1(ZAP70)Fkfr 		abnormal B cell physiology J:188422
abnormal neutrophil physiology J:188422
abnormal renal glomerular capsule morphology J:188422
abnormal renal glomerulus basement membrane morphology J:188422
arrested B cell differentiation J:188422
decreased B cell number J:188422
decreased blood urea nitrogen level J:188422
decreased bone marrow cell number J:188422
decreased circulating creatinine level J:188422
decreased DN1 thymic pro-T cell number J:188422
decreased IgG1 level J:188422
decreased IgG2a level J:188422
decreased IgG2b level J:188422
decreased marginal zone B cell number J:188422
decreased mature B cell number J:188422
decreased transitional stage B cell number J:188422
decreased transitional stage T1 B cell number J:188422
decreased transitional stage T2 B cell number J:188422
expanded mesangial matrix J:188422
glomerulonephritis J:188422
normal immune system phenotype J:188422
increased anti-insulin autoantibody level J:188422
increased B cell apoptosis J:188422
increased CD4-positive, alpha-beta memory T cell number J:188422
increased CD4-positive, alpha-beta T cell number J:188422
increased CD8-positive, alpha-beta memory T cell number J:188422
increased CD8-positive, alpha-beta T cell number J:188422
increased circulating glucose level J:188422
increased DN3 thymocyte number J:188422
increased IgM level J:188422
increased mesangial cell number J:188422
increased urine protein level J:188422
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory