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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Prdx1
peroxiredoxin 1
MGI:99523
46 phenotypes from 4 alleles in 4 genetic backgrounds
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Allelic Composition
Genetic Background		 Annotated Term Reference
Prdx1flro/Prdx1flro
C57BL/10JAnu-Prdx1flro/AnuApb 		abnormal erythrocyte morphology J:104190
abnormal lymphocyte morphology J:104190
Prdx1Gt(OST422296)Lex/Prdx1Gt(OST422296)Lex
B6.Cg-Prdx1Gt(OST422296)Lex 		abnormal redox activity J:103909
Prdx1tm1Rave/Prdx1+
involves: 129S6/SvEvTac * C57BL/6 		abnormal tumor morphology J:84677
hemolytic anemia J:84677
increased cellular sensitivity to hydrogen peroxide J:84677
increased cellular sensitivity to oxidative stress J:84677
increased fibrosarcoma incidence J:84677
increased hemangiosarcoma incidence J:84677
increased hepatocellular carcinoma incidence J:84677
increased histiocytic sarcoma incidence J:84677
increased lung adenocarcinoma incidence J:84677
increased lymphoma incidence J:84677
increased malignant tumor incidence J:84677
increased mammary adenocarcinoma incidence J:84677
increased osteosarcoma incidence J:84677
Prdx1tm1Rave/Prdx1tm1Rave
involves: 129S6/SvEvTac * C57BL/6 		abnormal cell cycle J:84677
abnormal erythrocyte morphology J:84677
abnormal NK T cell number J:84677
abnormal spleen morphology J:84677
anisocytosis J:84677
decreased cell proliferation J:84677
decreased circulating haptoglobin level J:84677
decreased hematocrit J:84677
decreased hemoglobin content J:84677
decreased tumor-free survival time J:84677
enlarged spleen J:84677
extramedullary hematopoiesis J:84677
hemolytic anemia J:84677
impaired natural killer cell mediated cytotoxicity J:84677
increased adenoma incidence J:84677
increased B cell derived lymphoma incidence J:84677
increased carcinoma incidence J:84677
increased cellular sensitivity to hydrogen peroxide J:84677
increased cellular sensitivity to oxidative stress J:84677
increased circulating lactate dehydrogenase level J:84677
increased fibrosarcoma incidence J:84677
increased hemangiosarcoma incidence J:84677
increased hemoglobin concentration distribution width J:84677
increased hepatocellular carcinoma incidence J:84677
increased histiocytic sarcoma incidence J:84677
increased lung adenocarcinoma incidence J:84677
increased lymphoma incidence J:84677
increased mammary adenocarcinoma incidence J:84677
increased pancreatic islet cell adenoma incidence J:84677
increased sarcoma incidence J:84677
increased spleen weight J:84677
increased T cell derived lymphoma incidence J:84677
increased tumor incidence J:84677
microcytosis J:84677
poikilocytosis J:84677
polychromatophilia J:84677
premature death J:84677
reticulocytosis J:84677
Prdx1tm1Yu/Prdx1tm1Yu
Not Specified 		decreased incidence of tumors by chemical induction J:306075
increased keratinocyte apoptosis J:306075
thin skin J:306075
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/17/2024
MGI 6.24 		The Jackson Laboratory