Pde4b Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Pde4b
phosphodiesterase 4B, cAMP specific
MGI:99557

24 phenotypes from 3 alleles in 7 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Pde4b^enu1H/Pde4b^enu1H B6.C(C3H)-Pde4b^enu1H	abnormal CNS synaptic transmission	J:223217
	abnormal learning/memory/conditioning	J:223217
	abnormal neuron differentiation	J:223217
	abnormal object recognition memory	J:223217
	normal behavior/neurological phenotype	J:223217
	decreased anxiety-related response	J:223217
	decreased synaptic depression	J:223217
	enhanced learning	J:223217
	enhanced long-term potentiation	J:223217
	enhanced spatial working memory	J:223217
	impaired cued conditioning behavior	J:223217
	increased exploration in new environment	J:223217
	increased post-tetanic potentiation	J:223217
	increased vertical activity	J:223217
	normal nervous system phenotype	J:223217
	normal taste/olfaction phenotype	J:223217
Pde4b^enu1H/Pde4b^enu1H Tg(Thy1-EGFP)#Jrs/0 involves: BALB/cAnN * C3H/HeH * C57BL/6 * CBA	increased dendritic spine density	J:223217
Pde4b^tm1Dgen/Pde4b^tm1Dgen involves: 129P2/OlaHsd * C57BL/6J	abnormal spinal cord morphology	J:82809
	brain vacuoles	J:82809
Pde4b^tm1Mct/Pde4b^tm1Mct B6N.129P2-Pde4b^tm1Mct/Mmucd	normal behavior/neurological phenotype	J:304450
Pde4b^tm1Mct/Pde4b^tm1Mct involves: 129P2/OlaHsd	normal cardiovascular system phenotype	J:96125
Pde4b^tm1Mct/Pde4b^tm1Mct involves: 129P2/OlaHsd * C57BL/6	decreased susceptibility to induced morbidity/mortality	J:106828
	decreased tumor necrosis factor secretion	J:106828
	impaired neutrophil chemotaxis	J:94853
	impaired neutrophil recruitment	J:94853
Pde4b^tm1Mct/Pde4b^tm1Mct involves: 129X1/SvJ * C57BL/6	decreased tumor necrosis factor secretion	J:76862

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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