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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		S1pr2
sphingosine-1-phosphate receptor 2
MGI:99569
60 phenotypes from 7 alleles in 9 genetic backgrounds
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Allelic Composition
Genetic Background		 Annotated Term Reference
S1pr2stdf/S1pr2stdf
involves: C57BL/6Brd * C57BL/6N 		abnormal organ of Corti morphology J:240361
abnormal stria vascularis vasculature morphology J:240361
abnormal strial marginal cell morphology J:240361
cochlear outer hair cell degeneration J:240361
decreased endocochlear potential J:240361
impaired hearing J:240361
increased or absent threshold for auditory brainstem response J:240361
stria vascularis degeneration J:240361
S1pr2tm1.1Toka/S1pr2tm1.1Toka
involves: C57BL/6J * C57BL/6N 		premature death J:214445
S1pr2tm1Ajml/S1pr2tm1Ajml
129S5/SvEvBrd-S1pr2tm1Ajml 		increased B cell derived lymphoma incidence J:154439
S1pr2tm1Ajml/S1pr2tm1Ajml
either: (involves: 129S5/SvEvBrd) or (involves: 129S5/SvEvBrd * C57BL/6) 		abnormal Rosenthal canal morphology J:112371
abnormal tectorial membrane morphology J:112371
abnormal vestibular system physiology J:112371
cochlear outer hair cell degeneration J:112371, J:231927
deafness J:112371, J:231927
decreased otolith number J:112371, J:231927
detached Reissner membrane J:112371
head tilt J:112371
impaired swimming J:112371
increased or absent threshold for auditory brainstem response J:112371
organ of Corti degeneration J:112371
otosclerosis J:112371
premature death J:112371
seizures J:112371
small scala media J:112371
thin stria vascularis J:112371, J:231927
vestibular saccular degeneration J:112371
S1pr2tm1Ajml/S1pr2tm1Ajml
involves: 129S5/SvEvBrd * C57BL/6 		abnormal action potential J:73957
abnormal brain wave pattern J:73957
abnormal CNS synaptic transmission J:73957
abnormal excitatory postsynaptic currents J:73957
abnormal nervous system electrophysiology J:73957
abnormal spleen marginal zone morphology J:154439
increased B cell derived lymphoma incidence J:154439
increased excitatory postsynaptic current amplitude J:73957
increased excitatory postsynaptic current frequency J:73957
increased germinal center B cell number J:154439
increased lung tumor incidence J:154439
increased spleen germinal center number J:154439
increased spleen germinal center size J:154439
increased T cell number J:154439
seizures J:73957
tonic-clonic seizures J:73957
S1pr2tm1Jch/S1pr2tm1Jch
involves: 129S1/Sv * 129X1/SvJ * C57BL/6N 		absent startle reflex J:118369
decreased litter size J:77809
S1pr2tm1Rlp/S1pr2tm1Rlp
involves: 129S6/SvEvTac * C57BL/6 		abnormal spleen germinal center morphology J:174313
abnormal stria vascularis morphology J:121165
abnormal stria vascularis vasculature morphology J:121165
abnormal strial basal cell morphology J:121165
abnormal strial intermediate cell morphology J:121165
abnormal strial marginal cell morphology J:121165
abnormal vestibular labyrinth morphology J:121165
absent distortion product otoacoustic emissions J:121165
normal cardiovascular system phenotype J:106055
cochlear ganglion degeneration J:121165
cochlear hair cell degeneration J:121165
deafness J:121165
decreased B cell apoptosis J:174313
decreased otolith number J:121165
enlarged otoliths J:121165
head tilt J:121165
increased B cell number J:174313
increased B cell proliferation J:174313
increased germinal center B cell number J:174313
increased or absent threshold for auditory brainstem response J:121165
increased T cell number J:174313
organ of Corti degeneration J:121165
S1pr2tm1Ytak/S1pr2tm1Ytak
involves: 129P2/OlaHsd * C57BL/6 		abnormal tumor morphology J:168060
abnormal tumor vascularization J:168060
increased angiogenesis J:168060
increased lung endothelial cell migration J:168060
increased tumor growth/size J:168060
postnatal lethality, incomplete penetrance J:168060
seizures J:168060
S1pr2tm2Ytak/S1pr2tm2Ytak
B6.129P2-S1pr2tm2Ytak 		normal nervous system phenotype J:168060
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory