Drd1 Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Drd1
dopamine receptor D1
MGI:99578

40 phenotypes from 8 alleles in 13 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Drd1^tm1(cre)Rpa/Drd1^tm1(cre)Rpa involves: 129S4/SvJaeSor * C57BL/6	abnormal behavior	J:138586
	decreased body size	J:138586
Drd1^tm1.1Mmsh/Drd1^tm1.1Mmsh Gng7^tm1(cre)Mmsh/? involves: C57BL/6N	normal behavior/neurological phenotype	J:210178
	impaired cued conditioning behavior	J:210178
Drd1^tm1Jcd/Drd1⁺ involves: 129S4/SvJae	abnormal contextual conditioning behavior	J:67395
Drd1^tm1Jcd/Drd1⁺ involves: 129S4/SvJae	abnormal passive avoidance behavior	J:67395
Drd1^tm1Jcd/Drd1^tm1Jcd B6.129S4-Drd1^tm1Jcd	increased startle reflex	J:154428
Drd1^tm1Jcd/Drd1^tm1Jcd B6.129S4-Drd1^tm1Jcd/J	abnormal eye electrophysiology	J:185955
	abnormal vision	J:185955
	decreased physiological sensitivity to xenobiotic	J:137069
	decreased response to stress-induced hyperthermia	J:137069
	decreased susceptibility to xenobiotic induced morbidity/mortality	J:137069
Drd1^tm1Jcd/Drd1^tm1Jcd involves: 129S4/SvJae	abnormal contextual conditioning behavior	J:67395
	abnormal inhibitory learning	J:102603
	abnormal neuronal migration	J:121219
	abnormal passive avoidance behavior	J:67395
	abnormal spatial learning	J:102600, J:102603
	behavioral despair	J:102600
	decreased body size	J:67395, J:102603
	decreased locomotor activity	J:102600
	decreased vertical activity	J:102600
	impaired coordination	J:102600
	increased thigmotaxis	J:102600
	loss of GABAergic neurons	J:121219
Drd1^tm1Jcd/Drd1^tm1Jcd involves: 129S4/SvJae * C57BL/6	decreased body weight	J:22076
	decreased vertical activity	J:22076
	disheveled coat	J:22076
	hunched posture	J:22076
	postnatal growth retardation	J:22076
	premature death	J:22076
Drd1^tm1Stl/Drd1^tm1Stl involves: 129P2/OlaHsd	abnormal response/metabolism to endogenous compounds	J:112986
	decreased physiological sensitivity to xenobiotic	J:112986
	hyperactivity	J:112986
	impaired behavioral response to cocaine	J:112986
	increased exploration in new environment	J:112986
Drd1^tm1Stl/Drd1^tm1Stl involves: 129P2/OlaHsd * C57BL/6	decreased body size	J:21603
	decreased body weight	J:21603
	decreased brain size	J:21603
	decreased striatum size	J:21603
	hyperactivity	J:21603
	impaired behavioral response to xenobiotic	J:21603
	postnatal lethality, incomplete penetrance	J:21603
Drd1^tm1Stl/Drd1^tm1Stl involves: 129P2/OlaHsd * C57BL/6J	impaired behavioral response to cocaine	J:127798
Drd1^tm1Stl/Drd1^tm1Stl involves: 129P2/OlaHsd * C57BL/6J	impaired behavioral response to xenobiotic	J:127798
Drd1^tm1Tono/Drd1^tm1Tono B6.129S-Drd1^tm1Tono	abnormal synaptic plasticity	J:143054
Drd1^tm2.1Stl/Drd1^tm2.1Stl involves: C57BL/6	no abnormal phenotype detected	J:211355
Drd1^tm2.1Stl/Drd1^tm2.1Stl Tg(Pomc-cre)1Lowl/0 involves: C57BL/6 * FVB/N	decreased fear-related response	J:211355
	impaired contextual conditioning behavior	J:211355
Drd1^tm2.2Stl/Drd1^tm2.2Stl involves: C57BL/6	preweaning lethality, complete penetrance	J:211355
Drd1^tm2Rpa/Drd1^tm2Rpa involves: 129S4/SvJae * C57BL/6 * C57BL/6J	impaired behavioral response to cocaine	J:121750
	impaired conditioned place preference behavior	J:121750

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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