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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Aldh2
aldehyde dehydrogenase 2, mitochondrial
MGI:99600
49 phenotypes from 8 alleles in 9 genetic backgrounds
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Allelic Composition
Genetic Background		 Annotated Term Reference
Aldh2Gt(OST7285)Lex/Aldh2Gt(OST7285)Lex
involves: 129S5/SvEvBrd * C57BL/6 		decreased alcohol consumption J:152060
enhanced behavioral response to alcohol J:152060
Aldh2tm1.1Mak/Aldh2+
involves: 129S6/SvEvTac * C57BL/6J 		abnormal enzyme/coenzyme activity J:223796
abnormal ethanol metabolism J:223796
decreased body weight J:223796
decreased leukocyte cell number J:223796
enhanced behavioral response to alcohol J:223796
hyperpigmentation J:223796
increased hepatocyte apoptosis J:223796
increased incidence of tumors by chemical induction J:223796
increased susceptibility to induced morbidity/mortality J:223796
Aldh2tm1.1Mak/Aldh2tm1.1Mak
involves: 129S6/SvEvTac * C57BL/6J 		abnormal enzyme/coenzyme activity J:223796
abnormal ethanol metabolism J:223796
decreased body weight J:223796
decreased leukocyte cell number J:223796
decreased tumor latency J:223796
enhanced behavioral response to alcohol J:223796
hyperpigmentation J:223796
increased hepatocyte apoptosis J:223796
increased incidence of tumors by chemical induction J:223796
increased susceptibility to induced morbidity/mortality J:223796
Aldh2tm1a(EUCOMM)Wtsi/Aldh2tm1a(EUCOMM)Wtsi
C57BL/6N-Aldh2tm1a(EUCOMM)Wtsi/Ieg 		abnormal bone mineralization J:165965
abnormal response to tactile stimuli J:165965
abnormal startle reflex J:165965
abnormal urination J:165965
decreased bone mineral density J:165965
decreased CD4-positive, alpha-beta T cell number J:165965
decreased CD8-positive, alpha-beta T cell number J:165965
decreased T cell number J:165965
increased circulating free fatty acids level J:165965
Aldh2tm1a(EUCOMM)Wtsi/Aldh2tm1a(EUCOMM)Wtsi
involves: C57BL/6J * C57BL/6N 		decreased litter size J:193232
Aldh2tm1a(EUCOMM)Wtsi/Aldh2tm1a(EUCOMM)Wtsi
Not Specified 		decreased circulating alkaline phosphatase level J:165965
decreased circulating cholesterol level J:165965
decreased circulating HDL cholesterol level J:165965
decreased circulating LDL cholesterol level J:165965
decreased circulating total protein level J:165965
Aldh2tm1b(EUCOMM)Wtsi/Aldh2tm1b(EUCOMM)Wtsi
C57BL/6N-Aldh2tm1b(EUCOMM)Wtsi/Ieg 		abnormal lens morphology J:211773
Aldh2tm1Bcgen/Aldh2tm1Bcgen
Not Specified 		abnormal hippocampus morphology J:285251
abnormal response to novel object J:285251
abnormal spatial working memory J:285251
Aldh2tm1Dmro/Aldh2+
B6.129-Aldh2tm1Dmro 		abnormal cardiac output J:261952
abnormal circulating hormone level J:261952
abnormal ethanol metabolism J:215904
abnormal heart rate J:261952
abnormal nociception after inflammation J:215904
cardiac hypertrophy J:261952
congestive heart failure J:261952
decreased cardiac muscle contractility J:261952
hyperalgesia J:215904
impaired exercise endurance J:261952
Aldh2tm1Kaw/Aldh2tm1Kaw
involves: 129P2/OlaHsd * C57BL/6 		abnormal cellular respiration J:63498
abnormal enzyme/coenzyme activity J:63498
Tg(EIF1AX-Aldh2*E487K)101Oht/Tg(EIF1AX-Aldh2*E487K)101Oht
C57BL/6-Tg(EIF1AX-Aldh2*E487K)101Oht 		abnormal coat/hair pigmentation J:137374
abnormal hippocampus morphology J:137374
abnormal object recognition memory J:137374
astrocytosis J:137374
hippocampus pyramidal cell degeneration J:137374
impaired spatial learning J:137374
increased sensitivity to induced cell death J:137374
muscle weakness J:137374
oxidative stress J:137374
premature death J:137374
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory