Aldh2 Phenotype Annotations - Multigenic Genotypes

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Aldh2
aldehyde dehydrogenase 2, mitochondrial
MGI:99600

43 phenotypes from multigenic genotypes

Allelic Composition Genetic Background	Annotated Term	Reference
Aldh2^{tm1a(EUCOMM)Wtsi}/Aldh2⁺ Fancd2^tm1Hou/Fancd2^tm1Hou involves: 129S4/SvJae * C57BL/6J * C57BL/6N	abnormal eye morphology	J:193232
	exencephaly	J:193232
Aldh2^{tm1a(EUCOMM)Wtsi}/Aldh2^{tm1a(EUCOMM)Wtsi} Fancd2^tm1Hou/Fancd2⁺ involves: 129S4/SvJae * C57BL/6J * C57BL/6N	maternal effect	J:193232
Aldh2^{tm1a(EUCOMM)Wtsi}/Aldh2^{tm1a(EUCOMM)Wtsi} Fancd2^tm1Hou/Fancd2^tm1Hou involves: 129S4/SvJae * C57BL/6J * C57BL/6N	abnormal bone marrow cell morphology/development	J:193232
	abnormal chest morphology	J:193232
	abnormal eye morphology	J:193232
	abnormal hematopoietic stem cell physiology	J:188123
	abnormal lymphopoiesis	J:193232
	abnormal spleen morphology	J:188123
	abnormal thymus morphology	J:188123
	anemia	J:188123, J:193232
	anophthalmia	J:193232
	decreased body weight	J:193232
	decreased bone marrow cell number	J:188123, J:193232
	decreased erythrocyte cell number	J:188123, J:193232
	decreased hematocrit	J:188123
	decreased hematopoietic stem cell number	J:188123
	decreased hemoglobin content	J:188123, J:193232
	decreased leukocyte cell number	J:188123
	embryonic lethality during organogenesis	J:193232
	enlarged spleen	J:193232
	exencephaly	J:193232
	extramedullary hematopoiesis	J:188123
	impaired hematopoiesis	J:193232
	increased acute lymphoblastic leukemia incidence	J:193232
	increased CD8-positive, alpha-beta T cell number	J:193232
	increased double-positive T cell number	J:193232
	increased lymphoma incidence	J:193232
	increased mean corpuscular volume	J:188123
	increased physiological sensitivity to xenobiotic	J:188123
	increased sensitivity to induced cell death	J:188123
	increased susceptibility to xenobiotic induced morbidity/mortality	J:193232
	increased T cell derived lymphoma incidence	J:193232
	kinked tail	J:193232
	lethargy	J:193232
	pancytopenia	J:188123
	premature death	J:193232
	thrombocytopenia	J:188123
	weight loss	J:193232
Apoe^tm1Unc/Apoe^tm1Unc Tg(EIF1AX-Aldh2E487K)101Oht/Tg(EIF1AX-Aldh2E487K)101Oht B6.Cg-Apoe^tm1Unc Tg(EIF1AX-Aldh2*E487K)101Oht	impaired spatial learning	J:137374
Tg(APPSWE)2576Kha/? Tg(EIF1AX-Aldh2E487K)101Oht/? involves: C57BL/6 SJL	abnormal object recognition memory	J:219346
	abnormal spatial working memory	J:219346
	amyloid beta deposits	J:219346
	astrocytosis	J:219346
	decreased body weight	J:219346
	premature death	J:219346
	tau protein deposits	J:219346

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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