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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Fgf8
fibroblast growth factor 8
MGI:99604
170 phenotypes from 16 alleles in 23 genetic backgrounds
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Allelic Composition
Genetic Background		 Annotated Term Reference
En1tm7(cre/ESR1)Alj/0
Fgf8tm1.1Jyhl/Fgf8tm1.3Mrt
involves: 129P2/OlaHsd * 129S6/SvEvTac 		abnormal midbrain morphology J:156717
abnormal neural tube morphology J:156717
abnormal Raphe nucleus morphology J:156717
abnormal rhombomere morphology J:156717
abnormal serotonergic neuron morphology J:156717
abnormal substantia nigra morphology J:156717
decreased dopaminergic neuron number J:156717
perinatal lethality, complete penetrance J:156717
small cerebellum J:156717
En1tm7(cre/ESR1)Alj/0
Fgf8tm1.3Mrt/Fgf8tm1.4Mrt
involves: 129P2/OlaHsd * 129S6/SvEvTac 		abnormal midbrain morphology J:156717
abnormal Raphe nucleus morphology J:156717
abnormal serotonergic neuron morphology J:156717
abnormal substantia nigra morphology J:156717
decreased dopaminergic neuron number J:156717
small cerebellum J:156717
Fgf8tm1(cre)Itl/Fgf8+
Not Specified 		no abnormal phenotype detected J:165806
Fgf8tm1.1Jyhl/Fgf8tm1.1Jyhl
involves: CD-1 		abnormal amnion morphology J:135128
abnormal developmental patterning J:135128
abnormal heart tube morphology J:135128
abnormal mesoderm development J:135128
abnormal pharyngeal arch morphology J:135128
abnormal primitive streak morphology J:135128
absent primitive node J:135128
decreased embryo size J:135128
open neural tube J:135128
Fgf8tm1.1Mrt/Fgf8tm1.1Mrt
involves: 129P2/OlaHsd 		absent cerebellum J:45909
absent inferior colliculus J:45909
absent olfactory bulb J:45909
neonatal lethality, complete penetrance J:45909
Fgf8tm1.1Mrt/Fgf8tm1.2Mrt
involves: 129P2/OlaHsd 		abnormal craniofacial development J:45909
abnormal heart development J:45909
abnormal hypothalamus morphology J:178252
abnormal midbrain morphology J:45909
abnormal pituitary gland morphology J:178252
abnormal rostral-caudal axis patterning J:45909
absent cerebellum J:45909
absent inferior colliculus J:45909
decreased embryo size J:45909
prenatal lethality, incomplete penetrance J:45909
small embryonic telencephalon J:45909
syndactyly J:45909
Fgf8tm1.1Mrt/Fgf8tm1.4Mrt
involves: 129P2/OlaHsd 		decreased neuron apoptosis J:111586
Fgf8tm1.1Mrt/Fgf8tm1.4Mrt
Foxg1tm1(cre)Skm/Foxg1+
involves: 129P2/OlaHsd 		increased neuron apoptosis J:111586
Fgf8tm1.2Mrt/Fgf8tm1.2Mrt
involves: 129P2/OlaHsd 		abnormal allantois morphology J:56519
abnormal amnion morphology J:56519
abnormal chorion morphology J:56519
abnormal ectoderm development J:56519
abnormal embryonic epiblast morphology J:56519
abnormal mesoderm development J:45909, J:56519
abnormal primitive streak elongation J:56519
absent heart J:45909, J:56519
absent primitive node J:56519
absent somites J:56519
decreased embryo size J:45909
embryonic lethality during organogenesis, complete penetrance J:45909
Fgf8tm1.2Mrt/Fgf8tm1.3Mrt
involves: 129P2/OlaHsd 		no abnormal phenotype detected J:45909
Fgf8tm1.2Mrt/Fgf8tm1.3Mrt
Foxg1tm1(cre)Skm/Foxg1+
involves: 129P2/OlaHsd 		abnormal cochlear sensory epithelium morphology J:122378
abnormal forebrain development J:122378
abnormal patterning of the organ of Corti J:122378
abnormal pillar cell differentiation J:122378
abnormal pillar cell morphology J:122378
absent pillar cells J:122378
perinatal lethality, complete penetrance J:122378
Fgf8tm1.2Mrt/Fgf8tm1.3Mrt
Tg(Nes-cre)1Atp/0
involves: 129P2/OlaHsd * FVB/N 		abnormal craniofacial development J:58999
abnormal craniofacial morphology J:58999
abnormal mandible morphology J:58999
abnormal maxilla morphology J:58999
abnormal trigeminal nerve morphology J:58999
absent incus J:58999
absent Meckel's cartilage J:58999
absent molars J:58999
decreased tongue size J:58999
increased apoptosis J:58999
neonatal lethality, complete penetrance J:58999
small first pharyngeal arch J:58999
Fgf8tm1.2Mrt/Fgf8tm1.4Mrt
involves: 129P2/OlaHsd 		abnormal allantois morphology J:56519
abnormal amnion morphology J:56519
abnormal chorion morphology J:56519
abnormal ectoderm development J:56519
abnormal embryonic epiblast morphology J:56519
abnormal mesoderm development J:56519
abnormal primitive streak elongation J:56519
absent heart J:56519
absent primitive node J:56519
absent somites J:56519
embryonic lethality during organogenesis, complete penetrance J:56519
Fgf8tm1.3Mrt/Fgf8+
Tbx1tm4(cre/Esr1*)Bld/Tbx1+
involves: 129P2/OlaHsd * 129S7/SvEvBrd 		abnormal aortic arch morphology J:110620
Fgf8tm1.3Mrt/Fgf8+
Six1tm1(cre)Xli/Six1+
involves: 129 * 129P2/OlaHsd * C57BL/6 		abnormal cardiac outflow tract development J:172023
cervical aortic arch J:172023
interrupted aortic arch J:172023
Fgf8tm1.3Mrt/Fgf8tm1.3Mrt
involves: 129P2/OlaHsd 		no abnormal phenotype detected J:45909
Fgf8tm1.3Mrt/Fgf8tm1.4Mrt
Foxg1tm1(cre)Skm/Foxg1+
involves: 129P2/OlaHsd 		increased neuron apoptosis J:111586
Fgf8tm1.3Mrt/Fgf8tm1.4Mrt
Nkx2-5tm1(cre)Rjs/Nkx2-5+
involves: 129P2/OlaHsd * 129S7/SvEvBrd 		abnormal heart tube morphology J:109474
absent cardiac outflow tract J:109474
absent heart right ventricle J:109474
dilated heart atrium J:109474
dilated heart left ventricle J:109474
embryonic lethality during organogenesis, complete penetrance J:109474
pharyngeal arch hypoplasia J:109474
Fgf8tm1.3Mrt/Fgf8tm1.4Mrt
Tbx1tm4(cre/Esr1*)Bld/Tbx1+
involves: 129P2/OlaHsd * 129S7/SvEvBrd 		abnormal aortic arch morphology J:110620
Fgf8tm1.3Mrt/Fgf8tm1.4Mrt
Tg(Msx2-cre)5Rem/0
involves: 129P2/OlaHsd * C57BL/6 * CBA * CD-1 * FVB/N 		abnormal digit development J:66266
abnormal forelimb stylopod morphology J:104411
abnormal forelimb zeugopod morphology J:66266, J:104411
abnormal hindlimb stylopod morphology J:66266, J:104411
abnormal hindlimb zeugopod morphology J:66266, J:104411
abnormal limb development J:104411
absent deltoid tuberosity J:104411
absent radius J:66266
oligodactyly J:104411
small limb buds J:66266
Fgf8tm1.3Mrt/Fgf8tm1.4Mrt
Tg(T-cre)1Lwd/0
involves: 129P2/OlaHsd * C3H * C57BL/6 * CD-1 		abnormal kidney development J:101175
abnormal ureteric bud morphology J:101175
absent renal glomerulus J:101175
hindlimb oligodactyly J:101175
impaired branching involved in ureteric bud morphogenesis J:101175
increased kidney apoptosis J:101175
kidney failure J:101175
neonatal lethality, complete penetrance J:101175
normal skeleton phenotype J:101175
Fgf8tm1.3Mrt/Fgf8tm1.4Mrt
Tg(Tbx1-cre)1Joe/0
involves: 129P2/OlaHsd 		abnormal cardiovascular system morphology J:88814
abnormal heart development J:88814
abnormal internal carotid artery morphology J:88814
abnormal thymus morphology J:88814
abnormal vascular smooth muscle morphology J:88814
aortic dissection J:88814
atrial septal defect J:88814
normal cardiovascular system phenotype J:88814
double outlet right ventricle J:88814
perimembraneous ventricular septal defect J:88814
perinatal lethality, incomplete penetrance J:88814
persistent truncus arteriosus J:88814
small thymus J:88814
transposition of great arteries J:88814
Fgf8tm1.3Mrt/Fgf8tm1.4Mrt
Tg(Tnnt2-cre)5Blh/0
involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6 * DBA/2 		normal cardiovascular system phenotype J:109474
Fgf8tm1.3Mrt/Fgf8tm2Mrt
Nkx2-5tm1(cre)Rjs/Nkx2-5+
involves: 129 * 129S7/SvEvBrd 		abnormal heart development J:109474
abnormal heart morphology J:109474
abnormal neural crest cell morphology J:109474
abnormal pharyngeal arch mesenchyme morphology J:109474
abnormal pharyngeal arch morphology J:109474
abnormal splanchnic mesoderm morphology J:109474
decreased mitotic index J:109474
normal mortality/aging J:109474
Fgf8tm1.4Mrt/Fgf8+
Tbx1tm4(cre/Esr1*)Bld/Tbx1+
involves: 129P2/OlaHsd * 129S7/SvEvBrd 		abnormal aortic arch morphology J:110620
Fgf8tm1.4Mrt/Fgf8tm1.4Mrt
involves: 129P2/OlaHsd 		abnormal allantois morphology J:56519
abnormal amnion morphology J:56519
abnormal chorion morphology J:56519
abnormal ectoderm development J:56519
abnormal embryonic epiblast morphology J:56519
abnormal mesoderm development J:56519
abnormal primitive streak elongation J:56519
absent heart J:56519
absent primitive node J:56519
absent somites J:56519
embryonic lethality during organogenesis, complete penetrance J:56519
Fgf8tm1b(KOMP)Wtsi/Fgf8tm1b(KOMP)Wtsi
C57BL/6N-Fgf8tm1b(KOMP)Wtsi/H 		embryonic lethality prior to tooth bud stage J:211773
preweaning lethality, complete penetrance J:211773
Fgf8tm1Jyhl/Fgf8tm1Jyhl
involves: CD-1 		abnormal cardiogenic mesoderm morphology J:135128
abnormal mesoderm development J:135128
abnormal neural fold formation J:135128
abnormal primitive streak morphology J:135128
abnormal somite development J:135128
absent mesoderm J:135128
Fgf8tm1Moon/Fgf8tm1Moon
Mesp1tm2(cre)Ysa/Mesp1+
involves: C57BL/6NCrlj * CBA/JNCrlj 		aberrant origin of the right subclavian artery J:170879
abnormal cardiac epithelial to mesenchymal transition J:170879
abnormal cardiac neural crest cell migration J:170879
abnormal cardiac outflow tract development J:170879
abnormal cardiovascular development J:170879
abnormal common carotid artery morphology J:170879
abnormal fourth pharyngeal arch artery morphology J:170879
abnormal pharyngeal arch artery morphology J:170879
abnormal sixth pharyngeal arch artery morphology J:170879
abnormal third pharyngeal arch artery morphology J:170879
decreased heart right ventricle size J:170879
double outlet right ventricle J:170879
right aortic arch J:170879
ventricular septal defect J:170879
Fgf8tm1Mrc/Fgf8tm1Moon
Hoxa3tm1(cre)Moon/Hoxa3+
involves: 129/Sv * C57BL/6 		abnormal coronary vessel morphology J:87304
abnormal fourth pharyngeal arch artery morphology J:87304
abnormal neural crest cell apoptosis J:87304
abnormal parathyroid gland morphology J:87304
abnormal pharyngeal arch artery morphology J:87304
abnormal truncus arteriosus septation J:87304
absent parathyroid glands J:87304
bicuspid aortic valve J:87304
ectopic parathyroid gland J:87304
ectopic thymus J:87304
enlarged third pharyngeal arch artery J:87304
neonatal lethality, incomplete penetrance J:87304
parathyroid hypoplasia J:87304
thymus hypoplasia J:87304
Fgf8tm1Mrc/Fgf8tm1Moon
Tfap2atm1(cre)Moon/Tfap2a+
involves: 129/Sv * C57BL/6 		abnormal blood vessel morphology J:87304
abnormal coronary artery morphology J:87304
abnormal craniofacial morphology J:87304
abnormal fourth pharyngeal arch artery morphology J:87304
abnormal neural crest cell apoptosis J:87304
abnormal pharyngeal arch artery morphology J:87304
abnormal subclavian artery morphology J:87304
absent fourth pharyngeal arch artery J:87304
absent sixth pharyngeal arch artery J:87304
enlarged third pharyngeal arch artery J:87304
fourth pharyngeal arch artery hypoplasia J:87304
interrupted aortic arch, type b J:87304
pharyngeal arch hypoplasia J:87304
postnatal lethality, complete penetrance J:87304
prenatal lethality, incomplete penetrance J:87304
retroesophageal right subclavian artery J:87304
right aortic arch J:87304
Fgf8tm1Mrc/Fgf8tm1Mrc
Not Specified 		prenatal lethality J:66265
Fgf8tm1Mrc/Fgf8tm2Moon
Foxa2tm2.1(cre/Esr1*)Moon/Foxa2+
Not Specified 		normal cardiovascular system phenotype J:143444
Fgf8tm1Mrc/Fgf8tm2Moon
Isl1tm1(cre)Sev/Isl1+
involves: 129S/Sv * Black Swiss * C57BL/6 		abnormal cardiac epithelial to mesenchymal transition J:143444
abnormal cardiac outflow tract development J:143444
abnormal conotruncal ridge morphology J:143444
persistent truncus arteriosus J:143444
Fgf8tm1Mrc/Fgf8tm2Mrc
Not Specified 		no abnormal phenotype detected J:66265
Fgf8tm1Mrc/Fgf8tm2Mrc
Hoxa3tm1(cre)Moon/Hoxa3+
involves: 129/Sv * C57BL/6 		abnormal coronary vessel morphology J:87304
abnormal fourth pharyngeal arch artery morphology J:87304
abnormal neural crest cell apoptosis J:87304
abnormal parathyroid gland morphology J:87304
abnormal pharyngeal arch artery morphology J:87304
abnormal truncus arteriosus septation J:87304
absent parathyroid glands J:87304
bicuspid aortic valve J:87304
ectopic parathyroid gland J:87304
ectopic thymus J:87304
enlarged third pharyngeal arch artery J:87304
neonatal lethality, incomplete penetrance J:87304
parathyroid hypoplasia J:87304
thymus hypoplasia J:87304
Fgf8tm1Mrc/Fgf8tm2Mrc
Tfap2atm1(cre)Moon/Tfap2a+
involves: 129/Sv * C57BL/6 		abnormal blood vessel morphology J:87304
abnormal coronary artery morphology J:87304
abnormal craniofacial morphology J:87304
abnormal fourth pharyngeal arch artery morphology J:87304
abnormal neural crest cell apoptosis J:87304
abnormal pharyngeal arch artery morphology J:87304
abnormal subclavian artery morphology J:87304
absent fourth pharyngeal arch artery J:87304
absent sixth pharyngeal arch artery J:87304
enlarged third pharyngeal arch artery J:87304
fourth pharyngeal arch artery hypoplasia J:87304
interrupted aortic arch, type b J:87304
pharyngeal arch hypoplasia J:87304
postnatal lethality, complete penetrance J:87304
prenatal lethality, incomplete penetrance J:87304
retroesophageal right subclavian artery J:87304
right aortic arch J:87304
Fgf8tm1Mrc/Fgf8tm2Mrc
Tg(Rarb-cre)1Mrc/0
Not Specified 		abnormal digit morphology J:66265
abnormal limb bone morphology J:66265
abnormal limb morphology J:66265
Fgf8tm1Mrc/Fgf8tm3Mrc
involves: 129 * C57BL/6 		abnormal cardiovascular system morphology J:87304
abnormal craniofacial morphology J:87304
abnormal neural crest cell apoptosis J:87304
abnormal truncus arteriosus septation J:87304
cyanosis J:87304
edema J:87304
fetal growth retardation J:87304
neonatal lethality, complete penetrance J:87304
third pharyngeal arch artery hypoplasia J:87304
Fgf8tm2.1Jyhl/Fgf8+
B6.129S6-Fgf8tm2.1Jyhl 		decreased body weight J:156717
normal preweaning lethality, incomplete penetrance J:156717
Fgf8tm2.1Jyhl/Fgf8tm2.1Jyhl
B6.129S6-Fgf8tm2.1Jyhl 		postnatal lethality, incomplete penetrance J:156717
Fgf8tm2.1Jyhl/Fgf8tm2.1Jyhl
involves: 129S6/SvEvTac * CD-1 		decreased body weight J:156717
normal nervous system phenotype J:156717
postnatal lethality J:156717
Fgf8tm2Moon/Fgf8tm1Mrc
Isl1tm1(cre)Sev/Isl1+
involves: 129S/Sv 		abnormal heart right ventricle morphology J:109475
abnormal truncus arteriosus septation J:109475
embryonic lethality during organogenesis, incomplete penetrance J:109475
increased apoptosis J:109475
persistent truncus arteriosus J:109475
small pharyngeal arch J:109475
Fgf8tm2Moon/Fgf8tm1Mrc
Mesp1tm2(cre)Ysa/Mesp1+
involves: C57BL/6 * CBA 		abnormal cardiac outflow tract development J:109475
abnormal heart tube morphology J:109475
bicuspid aortic valve J:109475
bicuspid pulmonary valve J:109475
common atrium J:109475
common ventricle J:109475
decreased cell proliferation J:109475
decreased heart right ventricle size J:109475
edema J:109475
embryonic lethality during organogenesis, incomplete penetrance J:109475
increased apoptosis J:109475
pericardial effusion J:109475
transposition of great arteries J:109475
Fgf8tm2Moon/Fgf8tm1Mrc
Tg(Mef2c-cre)2Blk/0
Not Specified 		double outlet right ventricle J:109475
transposition of great arteries J:109475
Fgf8tm2Mrc/Fgf8tm2Mrc
Not Specified 		no abnormal phenotype detected J:66265
Fgf8tm2Mrt/Fgf8+
involves: 129 * C57BL/6J * DBA/2J 		nervous system phenotype J:207892
Gt(ROSA)26Sortm1(Fgf8)Lma/Gt(ROSA)26Sor+
Tg(Msx2-cre)5Rem/0
involves: C57BL/6 * CBA 		abnormal calcaneum morphology J:223057
abnormal limb development J:223057
abnormal skeleton development J:223057
polydactyly J:223057
Gt(ROSA)26Sortm1(Fgf8)Lma/Gt(ROSA)26Sor+
Shhtm2(cre/ERT2)Cjt/Shh+
involves: 129S6/SvEvTac 		abnormal genital tubercle morphology J:223057
abnormal reproductive system physiology J:223057
Gt(ROSA)26Sortm1(Fgf8)Lma/Gt(ROSA)26Sor+
Shhtm2(cre/ERT2)Cjt/Shhtm2(cre/ERT2)Cjt
involves: 129S6/SvEvTac 		abnormal genital tubercle morphology J:223057
Gt(ROSA)26Sortm1(Fgf8)Lma/Gt(ROSA)26Sor+
Shhtm2(cre/ERT2)Cjt/Shhtm2(cre/ERT2)Cjt
Tg(Msx2-cre)5Rem/0
involves: 129S6/SvEvTac * C57BL/6 * CBA 		abnormal limb development J:223057
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/17/2024
MGI 6.24 		The Jackson Laboratory