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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Fgf8
fibroblast growth factor 8
MGI:99604
72 phenotypes from multigenic genotypes
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Allelic Composition
Genetic Background		 Annotated Term Reference
Chd7Gt(XK403)Byg/Chd7+
Fgf8tm1.2Mrt/Fgf8+
either: (involves: 129P2/OlaHsd * C57BL/6) or (involves: 129P2/OlaHsd * CD-1) 		abnormal fourth pharyngeal arch artery morphology J:154590
Chd7Gt(XK403)Byg/Chd7+
Fgf8tm2Mrt/Fgf8+
involves: 129 * 129P2/OlaHsd * C57BL/6J * DBA/2J 		abnormal inferior colliculus morphology J:207892
absent cerebellum vermis J:207892
small cerebellum J:207892
Ctnnb1tm2Kem/Ctnnb1tm2Kem
Gt(ROSA)26Sortm1(Fgf8)Lma/Gt(ROSA)26Sor+
Tg(Msx2-cre)5Rem/0
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA 		abnormal autopod morphology J:223057
abnormal hindlimb morphology J:223057
abnormal ulna morphology J:223057
normal limbs/digits/tail phenotype J:223057
Ctnnb1tm2Kem/Ctnnb1tm2Kem
Gt(ROSA)26Sortm1(Fgf8)Lma/Gt(ROSA)26Sor+
Shhtm1(EGFP/cre)Cjt/Shh+
involves: 129S1/Sv * 129X1/SvJ 		abnormal reproductive system development J:223057
abnormal tail development J:223057
normal reproductive system phenotype J:223057
Del(19Poll-Fbxw4)4Fsp/+
Fgf8tm1.4Mrt/Fgf8+
involves: 129P2/OlaHsd * 129S1/Sv 		abnormal brain development J:196292
abnormal brain morphology J:196292
abnormal craniofacial morphology J:196292
absent forelimb J:196292
absent hindlimb J:196292
absent kidney J:196292
absent olfactory bulb J:196292
embryonic growth retardation J:196292
prenatal lethality, incomplete penetrance J:196292
short limbs J:196292
En1tm7(cre/ESR1)Alj/0
Fgf8tm1.3Mrt/Fgf8tm2.1Jyhl
Gt(ROSA)26Sortm1Sor/0
involves: 129P2/OlaHsd * 129S6/SvEvTac 		normal growth/size/body region phenotype J:156717
normal nervous system phenotype J:156717
Fgf8tm1.1Mrt/Fgf8tm1.4Mrt
Foxg1tm1M/Foxg1+
involves: 129P2/OlaHsd 		abnormal neuron apoptosis J:111586
Fgf8tm1.3Mrt/Fgf8tm1.4Mrt
Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sortm1Sor
Nkx2-5tm1(cre)Rjs/Nkx2-5+
involves: 129P2/OlaHsd * 129S4/SvJaeSor * 129S7/SvEvBrd 		abnormal heart development J:109474
abnormal splanchnic mesoderm morphology J:109474
Fgf8tm1.3Mrt/Fgf8tm1.4Mrt
Tg(CAG-Bgeo,-Fgf4)1Mrt/?
Tg(Msx2-cre)5Rem/?
involves: 129P2/OlaHsd 		abnormal digit development J:104411
abnormal eyelid morphology J:104411
abnormal limb bud morphology J:104411
abnormal limb development J:104411
abnormal reproductive system morphology J:104411
fused tarsal bones J:104411
normal limbs/digits/tail phenotype J:104411
polysyndactyly J:104411
postnatal growth retardation J:104411
Fgf8tm1.4Mrt/Fgf8+
Tfap2atm1Will/Tfap2atm2.1Will
involves: 129P2/OlaHsd * 129S1/Sv * Black Swiss 		abnormal midface morphology J:217408
abnormal nasal pit morphology J:217408
cleft primary palate J:217408
unilateral cleft palate J:217408
Fgf8tm1.4Mrt/Fgf8+
Tbx1tm1Bld/Tbx1+
involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6 * ICR 		abnormal aortic arch development J:78686
abnormal aortic arch morphology J:78686
abnormal fourth pharyngeal arch artery morphology J:78686
cervical aortic arch J:78686
interrupted aortic arch, type b J:78686
right aortic arch J:78686
thymus hypoplasia J:78686
Fgf8tm1.4Mrt/Fgf8+
Fgf17tm1Dor/Fgf17tm1Dor
involves: 129P2/OlaHsd * 129S6/SvEvTac 		abnormal cerebellum anterior vermis morphology J:61429
abnormal cerebellum vermis morphology J:61429
abnormal gait J:61429
abnormal Purkinje cell morphology J:61429
decreased inferior colliculus size J:61429
Fgf8tm1.4Mrt/Fgf8+
Gli3tm1.1Alj/Gli3tm1.1Alj
involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6 		absent inferior colliculus J:137136
enlarged tectum J:137136
normal nervous system phenotype J:137136
Fgf8tm1Mrc/Fgf8+
Fgf9tm1Dor/Fgf9+
Fgfr3tm1.1Aomw/Fgfr3+
involves: 129 * BALB/c * C57BL/6 		impaired hearing J:143356
increased or absent threshold for auditory brainstem response J:143356
Fgf8tm1Mrc/Fgf8+
Fgfr3tm1.1Aomw/Fgfr3+
involves: 129 * BALB/c * C57BL/6 		impaired hearing J:143356
increased or absent threshold for auditory brainstem response J:143356
Fgf10tm1Ska/Fgf10+
Fgf8tm1Moon/Fgf8tm1Moon
Mesp1tm2(cre)Ysa/Mesp1+
involves: C57BL/6NCrlj * CBA/JNCrlj 		aberrant origin of the right subclavian artery J:170879
abnormal aortic arch morphology J:170879
abnormal cardiac outflow tract development J:170879
abnormal cardiovascular development J:170879
abnormal common carotid artery morphology J:170879
abnormal fourth pharyngeal arch artery morphology J:170879
abnormal pharyngeal arch artery morphology J:170879
abnormal sixth pharyngeal arch artery morphology J:170879
abnormal third pharyngeal arch artery morphology J:170879
decreased heart right ventricle size J:170879
double outlet right ventricle J:170879
right aortic arch J:170879
second pharyngeal arch hypoplasia J:170879
third pharyngeal arch hypoplasia J:170879
ventricular septal defect J:170879
Fgf10tm1Ska/Fgf10tm1Ska
Fgf8tm1Moon/Fgf8tm1Moon
Mesp1tm2(cre)Ysa/Mesp1+
involves: C57BL/6NCrlj * CBA/JNCrlj 		aberrant origin of the right subclavian artery J:170879
abnormal aortic arch morphology J:170879
abnormal cardiac epithelial to mesenchymal transition J:170879
abnormal cardiac neural crest cell migration J:170879
abnormal cardiac outflow tract development J:170879
abnormal cardiovascular development J:170879
abnormal common carotid artery morphology J:170879
abnormal fourth pharyngeal arch artery morphology J:170879
abnormal pharyngeal arch artery morphology J:170879
abnormal sixth pharyngeal arch artery morphology J:170879
abnormal third pharyngeal arch artery morphology J:170879
decreased heart right ventricle size J:170879
double outlet right ventricle J:170879
second pharyngeal arch hypoplasia J:170879
third pharyngeal arch hypoplasia J:170879
ventricular septal defect J:170879
Fgf17tm1Dor/Fgf17tm1Dor
Fgf8tm1.1Jyhl/Fgf8tm1.1Jyhl
involves: 129S6/SvEvTac 		abnormal cerebellum anterior vermis morphology J:156717
decreased inferior colliculus size J:156717
Gbx2tm1.1Mrt/Gbx2+
Fgf8tm1.4Mrt/Fgf8+
B6.129-Gbx2tm1.1Mrt Fgf8tm1.4Mrt 		abnormal pharyngeal arch artery morphology J:100584
retroesophageal right subclavian artery J:100584
right aortic arch J:100584
Gbx2tm1.1Mrt/Gbx2tm1.1Mrt
Fgf8tm1.4Mrt/Fgf8+
B6.129-Gbx2tm1.1Mrt Fgf8tm1.4Mrt 		abnormal neural crest cell migration J:100584
abnormal pharyngeal arch artery morphology J:100584
abnormal thymus development J:100584
interrupted aortic arch, type b J:100584
retroesophageal right subclavian artery J:100584
right aortic arch J:100584
small ears J:100584
small mandible J:100584
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
10/29/2024
MGI 6.24 		The Jackson Laboratory