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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Prdm1
PR domain containing 1, with ZNF domain
MGI:99655
70 phenotypes from 11 alleles in 12 genetic backgrounds
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Allelic Composition
Genetic Background		 Annotated Term Reference
Cd19tm1(cre)Cgn/Cd19+
Prdm1tm1Clme/Prdm1tm1Clme
involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ 		abnormal B cell differentiation J:101890
abnormal memory B cell number J:101890
abnormal plasma cell differentiation J:101890
abnormal plasma cell morphology J:101890, J:114881
decreased IgG level J:101890
decreased IgM level J:101890
decreased immunoglobulin level J:101890
decreased plasma cell number J:101890
increased spleen germinal center number J:101890
increased spleen germinal center size J:101890
Prdm1b2b1765Clo/Prdm1b2b1765Clo
C57BL/6J-Prdm1b2b1765Clo 		abnormal aortic valve morphology J:175213
abnormal left subclavian artery morphology J:175213
atrioventricular septal defect J:175213
double outlet right ventricle J:175213
right aortic arch J:175213
vascular ring J:175213
Prdm1em1(IMPC)Bay/Prdm1+
C57BL/6N-Prdm1em1(IMPC)Bay/BayMmucd 		abnormal embryo size J:211773
Prdm1em1(IMPC)Bay/Prdm1em1(IMPC)Bay
C57BL/6N-Prdm1em1(IMPC)Bay/BayMmucd 		abnormal heart morphology J:211773
embryonic lethality prior to tooth bud stage J:211773
preweaning lethality, complete penetrance J:211773
Prdm1tm1.1Clme/Prdm1+
involves: 129S1/Sv * 129X1/SvJ * FVB/N * ICR 		decreased primordial germ cell number J:101718
Prdm1tm1.1Clme/Prdm1tm1.1Clme
involves: 129S1/Sv * 129X1/SvJ * FVB/N * ICR 		abnormal dermomyotome development J:101718
abnormal dorsal aorta morphology J:101718
abnormal pharyngeal arch mesenchyme morphology J:101718
abnormal pharyngeal arch morphology J:101718
abnormal placenta labyrinth morphology J:101718
absent second pharyngeal arch J:101718
absent third pharyngeal arch J:101718
decreased embryo size J:101718
decreased primordial germ cell number J:101718
embryonic lethality during organogenesis, complete penetrance J:101718
hemorrhage J:101718
Prdm1tm1.1Clme/Prdm1tm1.1Liz
involves: 129S/SvEv * 129S1/Sv * 129X1/SvJ 		abnormal germ cell morphology J:153979
absent oocytes J:153979
azoospermia J:153979
decreased primordial germ cell number J:153979
decreased testis weight J:153979
forelimb oligodactyly J:153979
lethality throughout fetal growth and development, incomplete penetrance J:153979
postnatal lethality, incomplete penetrance J:153979
Prdm1tm1.1Clme/Prdm1tm2.1Liz
involves: 129S/SvEv * 129S1/Sv * 129X1/SvJ 		no abnormal phenotype detected J:153979
Prdm1tm1.1Clme/Prdm1tm2Rob
involves: 129S/Sv * 129X1/Sv * C57BL/6 * FVB/N * ICR 		abnormal dermomyotome development J:101718
abnormal dorsal aorta morphology J:101718
abnormal pharyngeal arch mesenchyme morphology J:101718
abnormal pharyngeal arch morphology J:101718
abnormal placenta labyrinth morphology J:101718
absent primordial germ cells J:101718
absent second pharyngeal arch J:101718
absent third pharyngeal arch J:101718
decreased embryo size J:101718
embryonic lethality during organogenesis, complete penetrance J:101718
hemorrhage J:101718
Prdm1tm1.1Liz/Prdm1tm1.1Liz
involves: 129S/SvEv 		abnormal splenocyte physiology J:163979
absent plasma cells J:196531
Prdm1tm1Clme/Prdm1tm1Clme
Tg(Itgax-cre)1-1Reiz/0
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA 		abnormal CD4-positive, alpha-beta T cell physiology J:178876
abnormal germinal center B cell physiology J:178876
abnormal immune system physiology J:178876
abnormal kidney morphology J:178876
abnormal mesangial cell morphology J:178876
abnormal T follicular helper cell differentiation J:178876
increased anti-double stranded DNA antibody level J:178876
increased anti-nuclear antigen antibody level J:178876
increased autoantibody level J:178876
increased germinal center B cell number J:178876
increased IgG level J:178876
increased immunoglobulin level J:178876
increased interleukin-6 secretion J:178876
increased spleen germinal center number J:178876
increased splenocyte number J:178876
increased T follicular helper cell number J:178876
increased urine protein level J:178876
kidney inflammation J:178876
Prdm1tm1Clme/Prdm1tm1Clme
Tg(Pdx1-cre)6Tuv/0
involves: 129S1/Sv * 129X1/SvJ * FVB/N 		normal endocrine/exocrine gland phenotype J:245611
Prdm1tm1Masu/Prdm1+
involves: 129P2/OlaHsd * C57BL/6 * CBA 		decreased primordial germ cell number J:99994
Prdm1tm1Masu/Prdm1tm1Masu
involves: 129P2/OlaHsd * C57BL/6 * CBA 		abnormal primordial germ cell migration J:99994
decreased primordial germ cell number J:99994
Prdm1tm1Nutt/Prdm1tm1Nutt
involves: C57BL/6 		prenatal lethality, complete penetrance J:93944
Prdm1tm1Rob/Prdm1+
involves: 129S/SvEv * C57BL/6 		decreased primordial germ cell number J:101718
Prdm1tm1Rob/Prdm1tm1Rob
involves: 129S/SvEv * C57BL/6 		abnormal dorsal aorta morphology J:101718
abnormal myotome development J:101718
abnormal pharyngeal arch mesenchyme morphology J:101718
abnormal pharyngeal arch morphology J:101718
abnormal placenta labyrinth morphology J:101718
abnormal third pharyngeal arch morphology J:101718
absent second pharyngeal arch J:101718
decreased embryo size J:101718
decreased primordial germ cell number J:101718
embryonic lethality during organogenesis, complete penetrance J:101718
hemorrhage J:101718
Prdm1tm2.1Liz/Prdm1tm2.1Liz
involves: 129S/SvEv 		normal immune system phenotype J:153979
no abnormal phenotype detected J:153979
Prdm1tm2.1Nutt/Prdm1tm2.1Nutt
Tg(Lck-cre)1Cwi/?
involves: C57BL/6 		increased susceptibility to Orthomyxoviridae infection J:151858
Prdm1tm2Rob/Prdm1+
involves: 129S/SvEv * C57BL/6 		decreased primordial germ cell number J:101718
Prdm1tm2Rob/Prdm1tm2Rob
involves: 129S/SvEv 		abnormal placenta development J:187742
abnormal spongiotrophoblast layer morphology J:187742
decreased trophoblast giant cell number J:187742
uterine hemorrhage J:187742
Prdm1tm2Rob/Prdm1tm2Rob
involves: 129S/SvEv * C57BL/6 		abnormal dorsal aorta morphology J:101718
abnormal myotome development J:101718
abnormal pharyngeal arch mesenchyme morphology J:101718
abnormal pharyngeal arch morphology J:101718
abnormal placenta labyrinth morphology J:101718
abnormal third pharyngeal arch morphology J:101718
absent second pharyngeal arch J:101718
decreased embryo size J:101718
decreased primordial germ cell number J:101718
embryonic lethality during organogenesis, complete penetrance J:101718
hemorrhage J:101718
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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11/12/2024
MGI 6.24 		The Jackson Laboratory