Syt1 Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Syt1
synaptotagmin I
MGI:99667

26 phenotypes from 5 alleles in 4 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Syt1^{tm1a(EUCOMM)Wtsi}/Syt1⁺ C57BL/6N-Syt1^{tm1a(EUCOMM)Wtsi}/Wtsi	decreased bone mineral content	J:211773
	decreased lean body mass	J:211773
Syt1^{tm1a(EUCOMM)Wtsi}/Syt1^{tm1a(EUCOMM)Wtsi} C57BL/6N-Syt1^{tm1a(EUCOMM)Wtsi}/Wtsi	abnormal coronary sinus connection	J:239583
	abnormal ductus venosus valve morphology	J:239583
	abnormal infrahyoid muscle connection	J:239583
	adrenal gland cyst	J:239583
	biliary cyst	J:239583
	dilated bile duct	J:239583
	no abnormal phenotype detected	J:239583
	perimembraneous ventricular septal defect	J:239583
	preweaning lethality, incomplete penetrance	J:211773
	thoracoschisis	J:239583
	thyroid gland cyst	J:239583
Syt1^tm1Sud/Syt1^tm1Sud involves: 129S4/SvJae	abnormal adrenal gland physiology	J:171203
	abnormal CNS synaptic transmission	J:21602
	abnormal excitatory postsynaptic currents	J:171203
	abnormal inhibitory postsynaptic currents	J:122459
	abnormal miniature excitatory postsynaptic currents	J:171203
	abnormal neuron physiology	J:167753
	abnormal neurotransmitter secretion	J:21602
	abnormal suckling behavior	J:21602
	abnormal synaptic transmission	J:171203
	decreased excitatory postsynaptic current amplitude	J:167753
	normal nervous system phenotype	J:171203
	postnatal lethality, complete penetrance	J:21602
Syt1^tm1Sud/Syt1^tm1Sud Tg(Thy1-Syt1/ECFP)1Sud/0 involves: 129S4/SvJae * C57BL/6 * SJL	abnormal synaptic transmission	J:105052
	postnatal lethality	J:105052
Syt1^tm2Sud/Syt1^tm2Sud involves: 129P2/OlaHsd * C57BL/6	no abnormal phenotype detected	J:76452
Syt1^tm3Sud/Syt1^tm3Sud involves: 129P2/OlaHsd * C57BL/6	abnormal neurotransmitter secretion	J:76452
Syt1^tm3Sud/Syt1^tm3Sud involves: 129P2/OlaHsd * C57BL/6	decreased excitatory postsynaptic current amplitude	J:76452
Syt1^tm4Sud/Syt1^tm4Sud involves: 129P2/OlaHsd * C57BL/6	no abnormal phenotype detected	J:76452

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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