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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Adcy3
adenylate cyclase 3
MGI:99675
66 phenotypes from 7 alleles in 10 genetic backgrounds
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Allelic Composition
Genetic Background		 Annotated Term Reference
Adcy3Jll/Adcy3+
C57BL/6J-Adcy3Jll 		decreased body weight J:223554
decreased brown fat cell size J:223554
decreased percent body fat/body weight J:223554
decreased susceptibility to diet-induced hepatic steatosis J:223554
decreased susceptibility to diet-induced obesity J:223554
decreased total body fat amount J:223554
decreased white fat cell size J:223554
Adcy3Jll/Adcy3+
involves: 129S1/SvImJ * C57BL/6J 		decreased body weight J:223554
decreased circulating glucose level J:223554
decreased circulating insulin level J:223554
decreased circulating leptin level J:223554
decreased percent body fat/body weight J:223554
decreased susceptibility to diet-induced obesity J:223554
decreased total body fat amount J:223554
hyperactivity J:223554
increased oxygen consumption J:223554
Adcy3Jll/Adcy3Jll
involves: 129S1/SvImJ * C57BL/6J 		decreased body weight J:223554
decreased susceptibility to diet-induced obesity J:223554
decreased total body fat amount J:223554
Adcy3tm1.1Dek/Adcy3tm1.1Dek
Tg(AQP2-cre)2Dek/0
involves: C57BL/6 * CBA 		normal renal/urinary system phenotype J:207417
Adcy3tm1.1Hazh/Adcy3tm1.1Hazh
involves: 129S6/SvEvTac * C57BL/6 		abnormal olfactory system physiology J:190988
Adcy3tm1a(EUCOMM)Wtsi/Adcy3+
C57BL/6N-Adcy3tm1a(EUCOMM)Wtsi/Wtsi 		decreased lean body mass J:211773
increased hematocrit J:211773
increased hemoglobin content J:211773
increased total body fat amount J:211773
Adcy3tm1a(EUCOMM)Wtsi/Adcy3tm1a(EUCOMM)Wtsi
C57BL/6N-Adcy3tm1a(EUCOMM)Wtsi/Wtsi 		preweaning lethality, incomplete penetrance J:211773
Adcy3tm1Dgen/Adcy3+
involves: 129P2/OlaHsd * C57BL/6 		no abnormal phenotype detected J:101679
Adcy3tm1Dgen/Adcy3tm1Dgen
involves: 129P2/OlaHsd * C57BL/6 		postnatal lethality, complete penetrance J:101679
Adcy3tm1Drs/Adcy3+
involves: 129X1/SvJ * C57BL/6 		impaired olfaction J:64745
Adcy3tm1Drs/Adcy3tm1Drs
involves: 129X1/SvJ * C57BL/6 		abnormal fertility/fecundity J:64745
abnormal olfaction J:83156
abnormal olfactory bulb morphology J:83156
abnormal olfactory neuron innervation pattern J:83156
anosmia J:64745
asthenozoospermia J:97802
decreased body weight J:64745
decreased circulating renin level J:144961
decreased litter size J:97802
decreased renal glomerular filtration rate J:144961
normal homeostasis/metabolism phenotype J:144961
impaired fertilization J:97802
impaired sperm capacitation J:97802
increased circulating creatinine level J:144961
obese J:144961
postnatal lethality, incomplete penetrance J:64745
premature acrosome reaction J:97802
reduced female fertility J:97802
reduced male fertility J:97802
normal renal/urinary system phenotype J:144961
Adcy3tm1Drs/Adcy3tm1Drs
involves: 129X1/SvJ * C57BL/6J 		abnormal CNS synaptic transmission J:281839
abnormal dendrite arborization pattern J:281839
abnormal depression-related behavior J:281839
abnormal excitatory postsynaptic potential J:281839
abnormal hippocampus CA1 region morphology J:281839
abnormal long-term spatial reference memory J:281839
abnormal nest building behavior J:281839
abnormal neuron physiology J:281839
abnormal non-rapid eye movement sleep pattern J:281839
abnormal object recognition memory J:281839
abnormal response to new environment J:281839
abnormal social investigation J:281839
anosmia J:281839
behavioral despair J:281839
decreased brain size J:281839
decreased brain weight J:281839
decreased dentate gyrus size J:281839
decreased grooming behavior J:281839
decreased hippocampus volume J:281839
hypoactivity J:281839
impaired spatial learning J:281839
increased frequency of paradoxical sleep J:281839
polyphagia J:281839
reduced long-term potentiation J:281839
small hippocampus J:281839
Adcy3tm2.1Drs/Adcy3tm2.1Drs
Emx1tm1(cre)Krj/Emx1+
involves: 129S2/SvPas * 129X1/SvJ 		abnormal depression-related behavior J:281839
abnormal long-term spatial reference memory J:281839
abnormal object recognition memory J:281839
abnormal response to new environment J:281839
behavioral despair J:281839
hypoactivity J:281839
impaired spatial learning J:281839
Adcy3tm2.1Drs/Adcy3tm2.1Drs
Ndor1Tg(UBC-cre/ERT2)1Ejb/Ndor1+
involves: 129 * 129X1/SvJ * C57BL/6 		abnormal circadian sleep/wake cycle J:281839
abnormal nest building behavior J:281839
abnormal non-rapid eye movement sleep pattern J:281839
abnormal response to new environment J:281839
behavioral despair J:281839
decreased grooming behavior J:281839
hypoactivity J:281839
increased circulating corticosterone level J:281839
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11/19/2024
MGI 6.24 		The Jackson Laboratory