Adcy1 Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Adcy1
adenylate cyclase 1
MGI:99677

25 phenotypes from 5 alleles in 9 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Adcy1^brl/Adcy1^brl B6.Cg-Adcy1^brl	abnormal excitatory postsynaptic currents	J:106269
Adcy1^brl/Adcy1^brl B6.Cg-Adcy1^brl	impaired synaptic plasticity	J:106269
Adcy1^brl/Adcy1^brl involves: C57BL/6	abnormal somatosensory cortex physiology	J:32194
	absent barrels in primary somatosensory cortex	J:32194
	disorganized barrel cortex	J:32194
Adcy1^tm1.1Ito/Adcy1^tm1.1Ito B6.129P2-Adcy1^tm1.1Ito	abnormal CNS synaptic transmission	J:137123
	abnormal thalamus morphology	J:137123
	absent barrels in primary somatosensory cortex	J:137123
Adcy1^{tm1b(EUCOMM)Wtsi}/Adcy1^{tm1b(EUCOMM)Wtsi} C57BL/6N-Adcy1^{tm1b(EUCOMM)Wtsi}/H	abnormal coat/hair pigmentation	J:211773
	abnormal gait	J:211773
	abnormal locomotor behavior	J:211773
	hyperactivity	J:211773
	improved glucose tolerance	J:211773
	increased circulating creatine kinase level	J:211773
	increased circulating phosphate level	J:211773
	increased leukocyte cell number	J:211773
	increased mean corpuscular volume	J:211773
Adcy1^tm1Drs/Adcy1^tm1Drs involves: 129 * Black Swiss	hyporesponsive to tactile stimuli	J:107678
Adcy1^tm1Drs/Adcy1^tm1Drs involves: 129 * Black Swiss	increased chemical nociceptive threshold	J:107678
Adcy1^tm1Drs/Adcy1^tm1Drs involves: 129S7/SvEvBrd	normal nervous system phenotype	J:164682
Adcy1^tm1Drs/Adcy1^tm1Drs involves: 129S7/SvEvBrd * C57BL/6	abnormal enzyme/coenzyme activity	J:22287
	abnormal excitatory postsynaptic potential	J:22287
	abnormal spatial learning	J:22287
Adcy1^tm1Ito/Adcy1^tm1.1Ito Emx1^tm1(cre)Ito/Emx1⁺ B6.129P2-Emx1^tm1(cre)Ito Adcy1^tm1Ito Adcy1^tm1.1Ito	abnormal barrel cortex morphology	J:137123
	decreased miniature excitatory postsynaptic current amplitude	J:137123
	normal nervous system phenotype	J:137123
	reduced long-term potentiation	J:137123
Adcy1^tm1Ito/Adcy1^tm1.1Ito Tg(Emx1-cre)3Ito/0 B6.Cg-Adcy1^tm1Ito Adcy1^tm1.1Ito Tg(Emx1-cre)3Ito	abnormal barrel cortex morphology	J:137123
	decreased miniature excitatory postsynaptic current amplitude	J:137123
	normal nervous system phenotype	J:137123
	reduced long-term potentiation	J:137123

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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