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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Rasgrf1
RAS protein-specific guanine nucleotide-releasing factor 1
MGI:99694
31 phenotypes from 11 alleles in 13 genetic backgrounds
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Allelic Composition
Genetic Background		 Annotated Term Reference
Meox2tm1(cre)Sor/Meox2+
Rasgrf1tm4.1Pds/Rasgrf1+
involves: 129S4/SvJaeSor * C57BL/6 		normal cellular phenotype J:117666
Rasgrf1enu1H/Rasgrf1+
involves: BALB/c * C3H/HeN 		decreased body weight J:84625
maternal imprinting J:84625
postnatal growth retardation J:84625
Rasgrf1enu1H/Rasgrf1+
involves: BALB/c * C3H/HeN * C57BL/6JOlaHsd 		decreased body weight J:84625
maternal imprinting J:84625
postnatal growth retardation J:84625
Rasgrf1enu2H/Rasgrf1+
involves: BALB/c * C3H/HeN 		decreased body weight J:84625
maternal imprinting J:84625
postnatal growth retardation J:84625
Rasgrf1enu2H/Rasgrf1+
involves: BALB/c * C3H/HeN * C57BL/6JOlaHsd 		decreased body weight J:84625
maternal imprinting J:84625
postnatal growth retardation J:84625
Rasgrf1tm1bNarl/Rasgrf1tm1bNarl
C57BL/6N-Rasgrf1tm1bNarl/Narl 		hyperactivity J:211773
increased lean body mass J:211773
Rasgrf1tm1Esn/Rasgrf1tm1Esn
involves: 129/Sv * C57BL/6N 		decreased body weight J:83950
decreased circulating insulin level J:83950
decreased pancreatic beta cell number J:83950
decreased total body fat amount J:83950
enhanced lipolysis J:83950
impaired glucose tolerance J:83950
small pancreatic islets J:83950
Rasgrf1tm1Kln/Rasgrf1tm1Kln
involves: 129/Sv * C57BL/6 		abnormal active avoidance behavior J:73879
abnormal excitatory postsynaptic potential J:73879
abnormal long-term spatial reference memory J:73879
normal behavior/neurological phenotype J:73879
impaired contextual conditioning behavior J:73879
impaired synaptic plasticity J:73879
normal nervous system phenotype J:73879
reduced long-term potentiation J:73879
Rasgrf1tm1Pds/Rasgrf1+
involves: 129S4/SvJae * C57BL/6 		abnormal imprinting J:75397
Rasgrf1tm1Sva/Rasgrf1tm1Sva
involves: 129S1/Sv * 129X1/SvJ * C57BL/6J 		abnormal discrimination learning J:91065
abnormal spatial learning J:91065
decreased body weight J:91065
impaired social transmission of food preference J:91065
Rasgrf1tm1Toc/Rasgrf1+
involves: 129 		abnormal pituitary secretion J:47681
decreased body weight J:47681
decreased circulating insulin-like growth factor I level J:47681
decreased growth hormone level J:47681
maternal imprinting J:47681
postnatal growth retardation J:47681
Rasgrf1tm1Toc/Rasgrf1tm1Toc
involves: 129 		decreased body weight J:47681
Rasgrf1tm2Pds/Rasgrf1+
involves: 129S4/SvJae 		abnormal DNA methylation J:103751
abnormal imprinting J:103751
Rasgrf1tm3.1Pds/Rasgrf1+
involves: FVB/N 		abnormal imprinting J:85825
paternal imprinting J:85825
Rasgrf1tm4.1Pds/Rasgrf1+
involves: 129S4/SvJaeSor * C57BL/6 		no abnormal phenotype detected J:117666
Rasgrf1tm4.1Pds/Rasgrf1+
Tg(Zp3-cre)3Mrt/0
involves: 129S4/SvJaeSor * C57BL/6 * FVB/N 		abnormal cell physiology J:117666
abnormal imprinting J:117666
Rasgrf1tm4.1Pds/Rasgrf1+
Tg(Nes-cre)1Kln/0
involves: 129S4/SvJaeSor * C57BL/6 * SJL 		normal cellular phenotype J:117666
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/05/2024
MGI 6.24 		The Jackson Laboratory