Chrna7 Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Chrna7
cholinergic receptor, nicotinic, alpha polypeptide 7
MGI:99779

44 phenotypes from 4 alleles in 9 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Chrna7^tm1.1Ehs/Chrna7^tm1.1Ehs involves: C57BL/6 * C57BL/6NTac	no abnormal phenotype detected	J:219327
Chrna7^tm1.1Ehs/Chrna7^tm1.1Ehs Tg(Gfap-cre)77.6Mvs/0 B6.Cg-Chrna7^tm1.1Ehs Tg(Gfap-cre)77.6Mvs	no abnormal phenotype detected	J:219327
Chrna7^{tm1b(EUCOMM)Hmgu}/Chrna7^{tm1b(EUCOMM)Hmgu} C57BL/6N-Chrna7^{tm1b(EUCOMM)Hmgu}/H	abnormal bone structure	J:211773
	increased circulating cholesterol level	J:211773
	increased circulating HDL cholesterol level	J:211773
Chrna7^tm1Bay/Chrna7⁺ B6.129S7-Chrna7^tm1Bay/J	impaired olfaction	J:166638
Chrna7^tm1Bay/Chrna7⁺ involves: 129S7/SvEvBrd * C3H/HeN	impaired olfaction	J:166638
Chrna7^tm1Bay/Chrna7^tm1Bay B6.129S7-Chrna7^tm1Bay/J	abnormal brain interneuron morphology	J:214099
	abnormal cerebral cortex morphology	J:214099
	abnormal cerebral cortex pyramidal cell morphology	J:214099
	abnormal GABA-mediated receptor currents	J:214099
	abnormal GABAergic neuron morphology	J:214099
	abnormal GABAergic neuron physiology	J:214099
	asthenozoospermia	J:115434
	decreased CNS synapse formation	J:214099
	decreased litter size	J:92540
	impaired olfaction	J:166638
	impaired spatial working memory	J:123663
	prolonged estrous cycle	J:92540
	reduced female fertility	J:92540
	normal reproductive system phenotype	J:92540, J:115434
Chrna7^tm1Bay/Chrna7^tm1Bay B6.Cg-Chrna7^tm1Bay	abnormal interleukin level	J:89610
	abnormal seizure response to pharmacological agent	J:74703
	abnormal spatial learning	J:51149
	abnormal tumor necrosis factor level	J:89610
	normal behavior/neurological phenotype	J:51149
	decreased anxiety-related response	J:51149
Chrna7^tm1Bay/Chrna7^tm1Bay involves: 129S7/SvEvBrd	failure of neuromuscular synapse presynaptic differentiation	J:161300
Chrna7^tm1Bay/Chrna7^tm1Bay involves: 129S7/SvEvBrd * C3H/HeN	impaired olfaction	J:166638
Chrna7^tm1Bay/Chrna7^tm1Bay involves: 129S7/SvEvBrd * C57BL/6	abnormal airway basal cell differentiation	J:154705
	airway basal cell hyperplasia	J:154705
	decreased IgG level	J:103908
	decreased immunoglobulin level	J:103908
	normal immune system phenotype	J:103908
Chrna7^tm1Bay/Chrna7^tm1Bay involves: 129S7/SvEvBrd * C57BL/6J	abnormal brain morphology	J:44288
	abnormal myeloblast morphology/development	J:140280
	abnormal nicotine-mediated receptor currents	J:44288
	decreased erythroblast number	J:140280
	decreased neutrophil cell number	J:140280
	increased lymphocyte cell number	J:140280
	normal nervous system phenotype	J:44288
	reduced fertility	J:44288
Chrna7^tm2Bay/Chrna7^tm2Bay involves: 129S7/SvEvBrd * C57BL/6J	abnormal brain morphology	J:61536
	abnormal nicotine-mediated receptor currents	J:61536
	abnormal somatosensory cortex morphology	J:61536
	abnormal suckling behavior	J:61536
	decreased locomotor activity	J:61536
	increased neuron apoptosis	J:61536
	neonatal lethality, complete penetrance	J:61536
	tremors	J:61536

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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