Lhx1 Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Lhx1
LIM homeobox protein 1
MGI:99783

80 phenotypes from 8 alleles in 11 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
En1^tm2(cre)Wrst/En1⁺ Lhx1^tm2.1Bhr/Lhx1^tm2.1Bhr involves: 129S1/Sv * 129S7/SvEvBrd * 129X1/SvJ	no abnormal phenotype detected	J:123471
H2az2^{Tg(Wnt1-cre)11Rth}/H2az2⁺ Tg(CAG-Lhx,-EGFP)1Eno/? involves: C3H * C57BL/6	failure of intramembranous bone ossification	J:150709
	frontal bone foramen	J:150709
	intracranial hemorrhage	J:150709
	neonatal lethality, complete penetrance	J:150709
Lhx1^{tm1a(EUCOMM)Wtsi}/Lhx1⁺ C57BL/6N-Lhx1^{tm1a(EUCOMM)Wtsi}/Ics	decreased circulating alkaline phosphatase level	J:165965
Lhx1^tm1Bhr/Lhx1⁺ involves: 129S7/SvEvBrd * C3H/He * C57BL/6 * ICR	no abnormal phenotype detected	J:98485
Lhx1^tm1Bhr/Lhx1^tm1Bhr involves: 129S7/SvEvBrd	abnormal primitive streak elongation	J:74124
	abnormal primitive streak formation	J:74124
	abnormal rostral-caudal axis patterning	J:74124
Lhx1^tm1Bhr/Lhx1^tm1Bhr involves: 129S7/SvEvBrd * C57BL/6	abnormal allantois morphology	J:24115
	abnormal anterior head development	J:24115
	abnormal brain development	J:24115
	abnormal egg cylinder morphology	J:24115
	abnormal gastrulation movements	J:24115
	abnormal hindbrain development	J:24115
	abnormal primitive node morphology	J:24115
	abnormal spinal cord morphology	J:24115
	absent forebrain	J:24115
	absent kidney	J:24115
	absent midbrain	J:24115
	absent ovary	J:24115
	absent prechordal mesoderm	J:24115
	absent testes	J:24115
	acephaly	J:24115
	agonadal	J:24115
	decreased embryo size	J:24115
	dilated allantois	J:24115
	embryonic lethality during organogenesis, incomplete penetrance	J:24115
	embryonic-extraembryonic boundary constriction	J:24115
	incomplete embryo turning	J:24115
	perinatal lethality, complete penetrance	J:24115
	rostral-caudal axis duplication	J:24115
	small allantois	J:24115
Lhx1^tm1Bhr/Lhx1^tm1Tmj involves: 129S/SvEv * C57BL/6	abnormal anterior head development	J:98831
	abnormal female reproductive system morphology	J:98831
	abnormal male reproductive system morphology	J:98831
	absent metanephros	J:98831
	absent ureter	J:98831
Lhx1^tm1Bhr/Lhx1^tm2.1Rob Edil3^{Tg(Sox2-cre)1Amc}/Edil3⁺ involves: 129S/SvEv * C57BL/6 * C57BL/6N * CBA	abnormal endoderm development	J:226614
	abnormal heart looping	J:226614
	abnormal heart morphology	J:226614
	abnormal nervous system development	J:226614
	abnormal primitive node morphology	J:226614
	cardia bifida	J:226614
	cellular necrosis	J:226614
	embryonic growth retardation	J:226614
	enlarged pericardium	J:226614
Lhx1^tm1Tmj/Lhx1^tm2.1Bhr Tg(Pax2-cre)10Shwl/0 involves: 129S1/Sv * 129S7/SvEvBrd * C57BL/6 * CD-1 * SJL	abnormal kidney morphology	J:104938
	abnormal ureter morphology	J:104938
	abnormal ureteric bud elongation	J:104938
	abnormal Wolffian duct morphology	J:104938
	duplex kidney	J:104938
	hydronephrosis	J:104938
	impaired branching involved in ureteric bud morphogenesis	J:104938
	neonatal lethality, complete penetrance	J:104938
	renal hypoplasia	J:104938
	rudimentary Mullerian ducts	J:104938
	rudimentary Wolffian ducts	J:104938
	single kidney	J:104938
	small kidney	J:104938
	Wolffian duct degeneration	J:104938
Lhx1^tm2.1Bhr/Lhx1^tm1Tmj Tg(Hoxb7-cre)13Amc/0 involves: 129S/SvEv * C57BL/6	abnormal mesonephros morphology	J:98831
	abnormal Mullerian duct morphology	J:98831
	abnormal ureter development	J:98831
	abnormal ureteric bud morphology	J:98831
	absent epididymis	J:98831
	absent Mullerian ducts	J:98831
	absent uterus	J:98831
	absent vas deferens	J:98831
	decreased nephron number	J:98831
	decreased renal glomerulus number	J:98831
	ectopic ureter	J:98831
	hydronephrosis	J:98831
	hydroureter	J:98831
	Mullerian duct degeneration	J:98831
	renal hypoplasia	J:98831
	rudimentary Mullerian ducts	J:98831
	small metanephros	J:98831
	uterus hypoplasia	J:98831
	Wolffian duct degeneration	J:98831
Lhx1^tm2.1Bhr/Lhx1^tm1Tmj Tg(Rarb-cre)1Bhr/0 involves: 129S/SvEv * C57BL/6 * SJL	abnormal kidney development	J:98831
	abnormal kidney medulla development	J:98831
	abnormal urinary bladder morphology	J:98831
	absent nephron	J:98831
	absent renal glomerulus	J:98831
	neonatal lethality, complete penetrance	J:98831
	renal hypoplasia	J:98831
	small metanephros	J:98831
Lhx1^tm3.1Bhr/Lhx1^tm3.1Bhr involves: 129S7/SvEvBrd * C57BL/6	abnormal anterior head development	J:63192
	abnormal neural tube morphology	J:63192
	abnormal primitive streak elongation	J:63192
	absent forebrain	J:63192
	absent midbrain	J:63192
	embryonic lethality during organogenesis, complete penetrance	J:63192
	embryonic-extraembryonic boundary constriction	J:63192
Lhx1^tm4Bhr/Lhx1^tm4Bhr Tg(Nes-cre)1Kln/0 involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL	neonatal lethality, complete penetrance	J:123471

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