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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Runx2
runt related transcription factor 2
MGI:99829
156 phenotypes from 13 alleles in 14 genetic backgrounds
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Allelic Composition
Genetic Background		 Annotated Term Reference
Gt(ROSA)26Sortm3(Runx2)Flng/Gt(ROSA)26Sortm3(Runx2)Flng
involves: 129X1/SvJ 		no abnormal phenotype detected J:180304
Runx2em1(IMPC)Rbrc/Runx2+
C57BL/6NJcl-Runx2em1(IMPC)Rbrc/Rbrc 		abnormal bone structure J:211773
abnormal clavicle morphology J:211773
abnormal cranium morphology J:211773
abnormal humerus morphology J:211773
abnormal pelvic girdle bone morphology J:211773
abnormal vertebrae morphology J:211773
abnormal vertebral arch morphology J:211773
abnormal zygomatic bone morphology J:211773
decreased bone mineral content J:211773
increased lean body mass J:211773
Runx2tm1.1Hkiy/Runx2tm1.1Hkiy
involves: 129P2/OlaHsd * C57BL/6 		normal mortality/aging J:223410
Runx2tm1.1Jals/Runx2tm1.1Jals
involves: 129S4/SvJae * 129S7/SvEvBrd * C57BL/6 		normal skeleton phenotype J:143532
Runx2tm1.1Yyon/Runx2tm1.1Yyon
Tg(Col1a1-cre)1Kry/0
involves: C57BL/6NCrlj * CBA/JNCrlj * FVB/N 		normal mortality/aging J:210124
normal skeleton phenotype J:210124
Runx2tm1.1Yyon/Runx2tm1.1Yyon
Tg(Col2a1-cre)1Star/0
involves: C57BL/6 * C57BL/6NCrlj * CBA/JNCrlj 		delayed bone ossification J:210124
delayed endochondral bone ossification J:210124
neonatal lethality, complete penetrance J:210124
respiratory distress J:210124
Runx2tm1Gss/Runx2+
involves: 129S7/SvEvBrd 		abnormal neurocranium morphology J:143532
absent clavicle J:143532
Runx2tm1Gss/Runx2+
involves: 129S7/SvEvBrd * C57BL/6 		absent clavicle J:70461
decreased body weight J:70461
normal skeleton phenotype J:70461
slow postnatal weight gain J:70461
Runx2tm1Gss/Runx2tm1Gss
involves: 129S7/SvEvBrd * C57BL/6 		abnormal bone mineralization J:70461
abnormal bone ossification J:70461
abnormal cartilage development J:70461
abnormal craniofacial bone morphology J:70461
abnormal limb development J:70461
abnormal vascular development J:70461
lethality throughout fetal growth and development, complete penetrance J:70461
Runx2tm1Hkiy/Runx2+
involves: 129P2/OlaHsd * C57BL/6 		delayed endochondral bone ossification J:223410
delayed intramembranous bone ossification J:223410
impaired osteoblast differentiation J:223410
small clavicle J:223410
Runx2tm1Hkiy/Runx2tm1Hkiy
involves: 129P2/OlaHsd * C57BL/6 		abnormal hyoid bone morphology J:223410
abnormal neurocranium morphology J:223410
abnormal phalanx morphology J:223410
abnormal skeleton development J:223410
absent clavicle J:223410
absent occipital bone J:223410
decreased bone mass J:223410
decreased bone mineral density of femur J:223410
decreased bone trabecula number J:223410
decreased bone volume J:223410
decreased trabecular bone thickness J:223410
decreased volumetric bone mineral density J:223410
delayed bone ossification J:223410
delayed endochondral bone ossification J:223410
delayed intramembranous bone ossification J:223410
delayed sagittal suture closure J:223410
impaired osteoblast differentiation J:223410
increased bone trabecular spacing J:223410
neonatal lethality, complete penetrance J:223410
Runx2tm1Jals/Runx2+
involves: 129S7/SvEvBrd * C57BL/6 		normal skeleton phenotype J:143532
Runx2tm1Jals/Runx2tm1Jals
involves: 129S7/SvEvBrd * C57BL/6 		abnormal bone ossification J:143532
abnormal clavicle morphology J:143532
abnormal cranial suture morphology J:143532
abnormal neurocranium morphology J:143532
abnormal osteoblast differentiation J:143532
abnormal skeleton development J:143532
abnormal trabecular bone morphology J:143532
clavicle hypoplasia J:143532
increased osteoblast proliferation J:143532
normal mortality/aging J:143532
small basisphenoid bone J:143532
wide cranial sutures J:143532
Runx2tm1Javed/Runx2tm1Javed
Tg(Col2a1-cre)1Bhr/0
involves: C57BL/6 * SJL 		abnormal craniofacial bone morphology J:212896
abnormal limb bone morphology J:212896
abnormal long bone epiphyseal plate morphology J:212896
abnormal metatarsal bone morphology J:212896
abnormal pelvic girdle bone morphology J:212896
absent metacarpal bones J:212896
absent scapula J:212896
absent vertebrae J:212896
decreased birth body size J:212896
decreased birth weight J:212896
neonatal lethality, complete penetrance J:212896
respiratory failure J:212896
short ribs J:212896
Runx2tm1Kish/Runx2+
involves: 129P2/OlaHsd * C57BL/6 		abnormal interparietal bone morphology J:40783
abnormal neurocranium morphology J:129364
abnormal parietal bone morphology J:40783
abnormal supraoccipital bone morphology J:40783
abnormal thyroid follicle morphology J:162258
abnormal thyroid gland morphology J:162258
clavicle hypoplasia J:40783, J:129364
decreased activity of thyroid gland J:162258
decreased circulating thyroxine level J:162258
decreased thyroxine level J:162258
decreased triiodothyronine level J:162258
delayed fontanelle closure J:129364
enlarged thymus J:162258
normal growth/size/body region phenotype J:40783
impaired adaptive thermogenesis J:162258
increased thyroid-stimulating hormone level J:162258
nasal bone hypoplasia J:40783
normal skeleton phenotype J:40783
Runx2tm1Kish/Runx2tm1Kish
involves: 129P2/OlaHsd * C57BL/6 		abnormal bone marrow cavity morphology J:40783, J:53069
abnormal bone ossification J:40783, J:59821
abnormal cartilage development J:54095
abnormal chondrocyte morphology J:59821
abnormal definitive hematopoiesis J:53069
abnormal dermal layer morphology J:40783
abnormal femur morphology J:40783
abnormal long bone epiphyseal ossification zone morphology J:40783, J:54095
abnormal long bone epiphyseal plate morphology J:54095
abnormal long bone epiphyseal plate proliferative zone J:59821
abnormal neurocranium morphology J:40783, J:59821
abnormal osteoblast differentiation J:40783, J:59821
abnormal osteoclast differentiation J:40783, J:59821
abnormal skeleton development J:40783
abnormal splenic cell ratio J:53069
abnormal tibia morphology J:40783, J:59821
anemia J:53069
cyanosis J:40783
decreased B cell number J:53069
decreased body weight J:40783
decreased diameter of tibia J:59821
decreased thymocyte number J:40783
disproportionate dwarf J:40783
enlarged spleen J:53069
extramedullary hematopoiesis J:53069
increased granulocyte number J:53069
increased nucleated erythrocyte cell number J:53069
increased width of hypertrophic chondrocyte zone J:54095
liver hypoplasia J:53069
normal muscle phenotype J:40783
neonatal lethality, complete penetrance J:40783
normal nervous system phenotype J:40783
respiratory failure J:40783
short limbs J:40783
small liver J:53069
Runx2tm1Ldq/Runx2+
involves: C57BL/6J 		abnormal tibia morphology J:89822
abnormal trabecular bone morphology J:89822
decreased birth body size J:89822
decreased birth weight J:89822
Runx2tm1Ldq/Runx2tm1Ldq
involves: C57BL/6J 		abnormal bone ossification J:89822
abnormal clavicle morphology J:89822
abnormal cranium morphology J:89822
abnormal hyoid bone morphology J:89822
abnormal long bone epiphysis morphology J:89822
abnormal nasal bone morphology J:89822
abnormal phalanx morphology J:89822
abnormal rib morphology J:89822
abnormal skeleton morphology J:89822
abnormal tibia morphology J:89822
abnormal trabecular bone morphology J:89822
absent occipital bone J:89822
absent zygomatic arch J:89822
decreased birth body size J:89822
decreased birth weight J:89822
decreased compact bone thickness J:89822
decreased length of long bones J:89822
delayed bone ossification J:89822
large anterior fontanelle J:89822
postnatal lethality, incomplete penetrance J:89822
premature death J:89822
Runx2tm1Mjo/Runx2+
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 		abnormal cartilage morphology J:40784
abnormal epidermis suprabasal layer morphology J:132568
abnormal fontanelle morphology J:40784
abnormal humerus morphology J:40784
abnormal long bone epiphyseal plate morphology J:40784
abnormal osteoblast differentiation J:40784
abnormal skin morphology J:132568
abnormal tooth development J:40784
abnormal xiphoid process morphology J:40784
absent deltoid tuberosity J:40784
clavicle hypoplasia J:40784
delayed endochondral bone ossification J:40784
delayed intramembranous bone ossification J:40784
hyoid bone hypoplasia J:40784
interparietal bone hypoplasia J:40784
ischium hypoplasia J:40784
parietal bone hypoplasia J:40784
pubis hypoplasia J:40784
thin epidermis J:132568
underdeveloped hair follicles J:132568
wide cranial sutures J:40784
Runx2tm1Mjo/Runx2+
Not Specified 		abnormal fontanelle morphology J:167992
abnormal hyoid bone morphology J:167992
clavicle hypoplasia J:167992, J:201597
Runx2tm1Mjo/Runx2tm1Mjo
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 		abnormal bone ossification J:40784
abnormal cartilage development J:40784
abnormal clavicle morphology J:40784
abnormal cranium morphology J:40784
abnormal lung volume J:40784
abnormal nose morphology J:40784
abnormal tooth development J:40784
absent bone marrow cell J:40784
decreased body size J:40784
decreased body weight J:40784
decreased osteoblast cell number J:40784
delayed endochondral bone ossification J:40784
delayed intramembranous bone ossification J:40784
increased nucleated erythrocyte cell number J:40784
neonatal lethality, complete penetrance J:40784
pulmonary vascular congestion J:40784
respiratory failure J:40784
Runx2tm1Mjo/Runx2tm1Mjo
involves: C57BL/6 * NMRI 		abnormal cervical loop morphology J:87161
abnormal dental lamina morphology J:87161
abnormal dental papilla morphology J:87161
abnormal enamel knot morphology J:87161
abnormal molar morphology J:87161
arrest of tooth development J:87161
cleft secondary palate J:87161
eyelids open at birth J:87161
growth retardation of incisors J:87161
growth retardation of molars J:87161
palatal shelves fail to meet at midline J:87161
Runx2tm1Mjo/Runx2tm1Mjo
Not Specified 		abnormal cartilage development J:53540
abnormal chondrocyte morphology J:53540
abnormal dentin morphology J:54817
abnormal enamel morphology J:54817
abnormal humerus morphology J:53540
abnormal incisor morphology J:54817
abnormal long bone epiphyseal plate morphology J:53540
abnormal long bone hypertrophic chondrocyte zone J:158761
abnormal radius morphology J:53540
abnormal skeleton development J:158761
abnormal ulna morphology J:53540
abnormal xiphoid process morphology J:158761
decreased angiogenesis J:158761
delayed endochondral bone ossification J:53540
growth retardation of incisors J:54817
growth retardation of molars J:54817
small incisors J:54817
small molars J:54817
Tg(Col1a1-Runx2)#Pmt/0
involves: BALB/c * C57BL/6 		abnormal bone mineralization J:167992
abnormal bone ossification J:167992
abnormal compact bone morphology J:167992
abnormal osteoblast differentiation J:167992
decreased bone mass J:167992
decreased compact bone thickness J:167992
decreased osteocyte number J:167992
fragile skeleton J:167992
increased osteoblast cell number J:167992
increased osteoclast cell number J:167992
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory