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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Runx2
runt related transcription factor 2
MGI:99829
41 phenotypes from multigenic genotypes
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Allelic Composition
Genetic Background		 Annotated Term Reference
FlnbGt(XD076)Byg/FlnbGt(XD076)Byg
Runx2tm1Mjo/Runx2+
involves: 129P2/OlaHsd * C57BL/6 		abnormal sternebra morphology J:134094
normal skeleton phenotype J:134094
small occipital bone J:134094
wide cranial sutures J:134094
Gsk3btm1Jrw/Gsk3b+
Runx2tm1Kish/Runx2+
involves: 129 * 129P2/OlaHsd * C57BL/6 		abnormal clavicle morphology J:129364
abnormal fontanelle morphology J:129364
Gt(ROSA)26Sortm3(Runx2)Flng/Gt(ROSA)26Sor+
Runx2tm1Mjo/Runx2tm1Mjo
Tg(Col2a1-cre)3Amc/0
involves: 129X1/SvJ 		abnormal bone marrow cavity morphology J:180304
abnormal bone ossification J:180304
normal skeleton phenotype J:180304
Gt(ROSA)26Sortm3(Runx2)Flng/Gt(ROSA)26Sortm3(Runx2)Flng
Ihhtm1Amc/Ihhtm1Amc
Tg(Col2a1-cre)3Amc/0
involves: 129S1/Sv * 129X1/SvJ 		abnormal bone ossification J:180304
abnormal bone structure J:180304
abnormal long bone epiphyseal plate morphology J:180304
abnormal long bone hypertrophic chondrocyte zone J:180304
abnormal osteoblast differentiation J:180304
Gt(ROSA)26Sortm3(Runx2)Flng/Gt(ROSA)26Sortm3(Runx2)Flng
Runx2tm1Mjo/Runx2tm1Mjo
Tg(Col2a1-cre)3Amc/0
involves: 129X1/SvJ 		abnormal bone ossification J:180304
normal skeleton phenotype J:180304
Hivep3tm1Glm/Hivep3tm1Glm
Runx2tm1Mjo/Runx2+
involves: C57BL/6 		clavicle hypoplasia J:201597
Runx1tm1.1Stkd/Runx1tm1.1Stkd
Runx2tm1Mjo/Runx2tm1Mjo
Tg(Col2a1-cre)1Star/0
involves: C57BL/6 		abnormal skeleton morphology J:158761
Runx1tm1.1Stkd/Runx1tm1.1Stkd
Runx2tm1Mjo/Runx2tm1Mjo
Tg(Prrx1-cre)1Cjt/0
involves: C57BL/6J * SJL/J 		abnormal bone mineralization J:158761
abnormal chondrocyte differentiation J:158761
abnormal skeleton development J:158761
absent sternum J:158761
preweaning lethality, complete penetrance J:158761
Runx2tm1Mjo/Runx2+
Twist1tm1Bhr/Twist1+
involves: 129S7/SvEvBrd * C57BL/6 		clavicle hypoplasia J:90056
normal craniofacial phenotype J:90056
Runx2tm1Mjo/Runx2+
Runx3tm1Yg/Runx3tm1Yg
involves: 129S1/Sv * 129X1/SvJ * ICR 		delayed bone ossification J:224290
postnatal lethality, incomplete penetrance J:224290
Runx2tm1Mjo/Runx2+
Twist2tm1(cre)Dor/Twist2+
involves: 129X1/SvJ * C57BL/6 		clavicle hypoplasia J:90056
Runx2tm1Mjo/Runx2+
Twist2tm1(cre)Dor/Twist2tm1(cre)Dor
involves: 129X1/SvJ * C57BL/6 		delayed fontanelle closure J:90056
normal skeleton phenotype J:90056
small interparietal bone J:90056
Runx2tm1Mjo/Runx2+
Satb2tm1Rug/Satb2+
Not Specified 		abnormal bone ossification J:115876
abnormal bone structure J:115876
decreased bone trabecula number J:115876
decreased bone volume J:115876
Runx2tm1Mjo/Runx2+
Tg(Eno2tTA)#Nes/0
Tg(tetO-Zfp521)#Rbar/0
involves: C57BL/6 * SJL 		abnormal fontanelle morphology J:167992
abnormal hyoid bone morphology J:167992
clavicle hypoplasia J:167992
Runx2tm1Mjo/Runx2+
Zfp521tm2Ngc/Zfp521+
Not Specified 		clavicle hypoplasia J:167992
decreased hyoid bone size J:167992
Runx2tm1Mjo/Runx2+
Runx3tm3Yg/Runx3tm3Yg
Tg(Col1a1-cre)1Kry/0
involves: FVB/N 		decreased body height J:224290
decreased body size J:224290
Tg(Col1a1-Runx2)#Pmt/0
Tg(Eno2tTA)#Nes/0
Tg(tetO-Zfp521)#Rbar/0
involves: BALB/c * C57BL/6 * SJL 		abnormal bone mineralization J:167992
decreased compact bone thickness J:167992
decreased osteocyte number J:167992
fragile skeleton J:167992
normal skeleton phenotype J:167992
Tle5tm1Grid/Tle5tm1Grid
Runx2tm1Mjo/Runx2+
involves: 129S1/Sv * C57BL/6 		abnormal fontanelle morphology J:92187
abnormal long bone hypertrophic chondrocyte zone J:92187
abnormal skeleton development J:92187
clavicle hypoplasia J:92187
decreased body weight J:92187
decreased bone mineral density J:92187
decreased long bone epiphyseal plate size J:92187
decreased width of hypertrophic chondrocyte zone J:92187
disproportionate dwarf J:92187
female infertility J:92187
male infertility J:92187
postnatal growth retardation J:92187
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory