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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Otp
orthopedia homeobox
MGI:99835
30 phenotypes from 4 alleles in 6 genetic backgrounds
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Allelic Composition
Genetic Background		 Annotated Term Reference
OtpM1H/Otp+
C3H.Cg-OtpM1H 		abnormal energy homeostasis J:251771
abnormal fat pad morphology J:251771
decreased body weight J:251771
decreased bone mineral density J:251771
impaired glucose tolerance J:251771
increased body fat mass J:251771
increased body length J:251771
increased circulating insulin level J:251771
increased circulating leptin level J:251771
increased energy expenditure J:251771
increased food intake J:251771
increased lean body mass J:251771
increased white adipose tissue amount J:251771
insulin resistance J:251771
obese J:251771
OtpM1H/OtpM1H
C3H.Cg-OtpM1H 		preweaning lethality, complete penetrance J:251771
OtpM1H/Otptm1Asim
involves: 129P2/OlaHsd * C3H/HeH * C57BL/6J 		preweaning lethality, complete penetrance J:251771
Otptm1Asim/Otp+
C3H.129P2(B6)-Otptm1Asim 		impaired glucose tolerance J:251771
increased body fat mass J:251771
increased circulating leptin level J:251771
increased lean body mass J:251771
insulin resistance J:251771
obese J:251771
Otptm1Asim/Otptm1Asim
involves: 129P2/OlaHsd 		abnormal dopaminergic neuron morphology J:122105
Otptm1b(EUCOMM)Wtsi/Otp+
C57BL/6N-Otptm1b(EUCOMM)Wtsi/H 		decreased mean platelet volume J:211773
increased circulating iron level J:211773
Otptm1b(EUCOMM)Wtsi/Otptm1b(EUCOMM)Wtsi
C57BL/6N-Otptm1b(EUCOMM)Wtsi/H 		preweaning lethality, complete penetrance J:211773
Otptm1Tlu/Otptm1Tlu
either: 129/Sv-Otptm1Tlu or (involves: 129S1/Sv * 129X1/SvJ * C57BL/6) 		abnormal diencephalon morphology J:65759
abnormal hypothalamus morphology J:65759
abnormal hypothalamus physiology J:65759
abnormal neurohypophysis median eminence morphology J:65759
abnormal neurohypophysis morphology J:65759
abnormal paraventricular hypothalamic nucleus morphology J:65759
abnormal supraoptic nucleus morphology J:65759
abnormal third ventricle morphology J:65759
decreased body size J:65759
decreased body weight J:65759
decreased brain size J:65759
postnatal lethality, complete penetrance J:65759
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory