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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Cbfb
core binding factor beta
MGI:99851
113 phenotypes from 14 alleles in 15 genetic backgrounds
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Allelic Composition
Genetic Background		 Annotated Term Reference
Cbfbtm1.1Ddg/Cbfbtm1.1Ddg
involves: 129S6/SvEvTac 		no abnormal phenotype detected J:226826
Cbfbtm1Itan/Cbfbtm1Itan
Tg(Cd4-cre)1Cwi/0
involves: 129P2/OlaHsd * C57BL/6 * DBA/2 		abnormal CD8-positive, alpha beta T cell morphology J:125953, J:158962
abnormal CD8-positive, alpha-beta T cell number J:125953
abnormal T cell differentiation J:125953
abnormal T-helper 1 cell differentiation J:125953
decreased CD8-positive, alpha-beta T cell number J:158962
increased double-positive T cell number J:158962
increased IgA level J:125953
increased IgE level J:125953
increased IgG1 level J:125953
increased immunoglobulin level J:125953
lung inflammation J:125953
Cbfbtm1Itan/Cbfbtm1Itan
Tg(KRT14-cre)1Amc/0
involves: 129P2/OlaHsd * C57BL/6 * CBA 		abnormal palate development J:277246
anterior cleft palate J:277246
submucous cleft palate J:277246
Cbfbtm1Itan/Cbfbtm1Itan
Tg(Lck-cre)1Cwi/0
involves: 129P2/OlaHsd 		abnormal CD4-positive T cell differentiation J:125953
abnormal CD8-positive, alpha-beta T cell differentiation J:125953
abnormal double-positive T cell morphology J:125953
abnormal T-helper 1 cell differentiation J:125953
decreased thymocyte number J:125953
Cbfbtm1Lhc/Cbfb+
Tg(EIIa-cre)C5379Lmgd/0
involves: 129S6/SvEvTac * C57BL/6 * FVB/N 		embryonic lethality, complete penetrance J:105040
impaired hematopoiesis J:105040
Cbfbtm1Lhc/Cbfbtm1Lhc
Tg(Mx1-cre)1Cgn/0
involves: 129S6/SvEvTac * C57BL/6 * CBA 		abnormal liver morphology J:105040
abnormal megakaryocyte differentiation J:105040
abnormal myelopoiesis J:105040
abnormal spleen morphology J:105040
anemia J:105040
enlarged spleen J:105040
increased hematopoietic stem cell number J:105040
increased leukocyte cell number J:105040
thrombocytopenia J:105040
Cbfbtm1Ppl/Cbfb+
either: (involves: 129/Sv * 129S6/SvEvTac) or (involves: 129S6/SvEvTac * Black Swiss) or (involves: 129S6/SvEvTac * C57BL/6) 		brainstem hemorrhage J:36594
embryonic lethality during organogenesis, complete penetrance J:36594
extramedullary hematopoiesis J:36594
hemopericardium J:36594
hemoperitoneum J:36594
impaired hematopoiesis J:36594
increased apoptosis J:36594
internal hemorrhage J:36594
intracranial hemorrhage J:36594
intraventricular hemorrhage J:36594
pale liver J:36594
small liver J:36594
spinal hemorrhage J:36594
Cbfbtm1Spe/Cbfbtm1Spe
either: (involves: 129S4/SvJae * BALB/c) or (involves: 129S4/SvJae * C57BL/6) 		abnormal capillary morphology J:36593
abnormal myeloblast morphology/development J:36593
decreased erythroblast number J:36593
edema J:36593
embryonic lethality during organogenesis, complete penetrance J:36593
hemorrhage J:36593
impaired hematopoiesis J:36593
increased apoptosis J:36593
intracranial hemorrhage J:36593
intraventricular hemorrhage J:36593
spinal hemorrhage J:36593
Cbfbtm1Spe/Cbfbtm1Spe
Tg(Tek-GFP/Cbfb)1Spe/0
either: (involves: 129S4/SvJae * BALB/c * CD-1) or (involves: 129S4/SvJae * C57BL/6 * CD-1) 		abnormal common myeloid progenitor cell morphology J:80670
abnormal definitive hematopoiesis J:80670
abnormal erythropoiesis J:80670
abnormal liver morphology J:80670
abnormal long bone hypertrophic chondrocyte zone J:80670
abnormal myelopoiesis J:80670
abnormal osteoblast differentiation J:80670
abnormal splenic cell ratio J:80670
bowed tibia J:80670
delayed bone ossification J:80670
delayed chondrocyte differentiation J:80670
delayed endochondral bone ossification J:80670
delayed intramembranous bone ossification J:80670
eyelids open at birth J:80670
increased CD4-positive, alpha-beta T cell number J:80670
increased erythroid progenitor cell number J:80670
increased hematopoietic stem cell number J:80670
perinatal lethality, complete penetrance J:80670
protruding tongue J:80670
short limbs J:80670
short snout J:80670
small thymus J:80670
spleen hypoplasia J:80670
Cbfbtm1Spe/Cbfbtm1Spe
Tg(Tek-GFP/Cbfb)2Spe/0
either: (involves: 129S4/SvJae * BALB/c * CD-1 * Swiss Webster) or (involves: 129S4/SvJae * C57BL/6 * CD-1 * Swiss Webster) 		abnormal common myeloid progenitor cell morphology J:80670
abnormal definitive hematopoiesis J:80670
abnormal erythropoiesis J:80670
abnormal liver morphology J:80670
abnormal long bone hypertrophic chondrocyte zone J:80670
abnormal myelopoiesis J:80670
abnormal osteoblast differentiation J:80670
abnormal splenic cell ratio J:80670
bowed tibia J:80670
delayed bone ossification J:80670
delayed chondrocyte differentiation J:80670
delayed endochondral bone ossification J:80670
delayed intramembranous bone ossification J:80670
eyelids open at birth J:80670
increased CD4-positive, alpha-beta T cell number J:80670
increased erythroid progenitor cell number J:80670
increased hematopoietic stem cell number J:80670
perinatal lethality, complete penetrance J:80670
protruding tongue J:80670
short limbs J:80670
short snout J:80670
small thymus J:80670
spleen hypoplasia J:80670
Cbfbtm1Spe/Cbfbtm2.1Spe
involves: 129S4/SvJae 		abnormal axial skeleton morphology J:124224
abnormal clavicle morphology J:124224
abnormal cranium morphology J:124224
abnormal limb bone morphology J:124224
abnormal long bone diaphysis morphology J:124224
abnormal mandible morphology J:124224
abnormal maxilla morphology J:124224
abnormal megakaryocyte morphology J:124224
abnormal metacarpal bone morphology J:124224
abnormal metatarsal bone morphology J:124224
abnormal neurocranium morphology J:124224
abnormal pectoral girdle bone morphology J:124224
abnormal phalanx morphology J:124224
abnormal rib morphology J:124224
abnormal scapula morphology J:124224
abnormal skeleton development J:124224
abnormal splenic cell ratio J:124224
abnormal sternum morphology J:124224
abnormal T cell differentiation J:124224
abnormal thymus cell ratio J:124224
abnormal thymus morphology J:124224
abnormal vertebrae development J:124224
decreased double-positive T cell number J:124224
extramedullary hematopoiesis J:124224
increased CD4-positive, alpha-beta T cell number J:124224
neonatal lethality, complete penetrance J:124224
thrombocytopenia J:124224
thymus hypoplasia J:124224
Cbfbtm1Tno/Cbfbtm1Tno
involves: 129S4/SvJae * C57BL/6J 		abnormal definitive hematopoiesis J:40963
abnormal embryonic hematopoiesis J:40963
abnormal liver development J:40963
embryonic lethality during organogenesis, complete penetrance J:40963
intraventricular hemorrhage J:40963
spinal hemorrhage J:40963
Cbfbtm1Tok/Cbfbtm1Tok
involves: 129P2/OlaHsd * C57BL/6J 		abnormal definitive hematopoiesis J:36250
embryonic lethality during organogenesis, complete penetrance J:36250
intracranial hemorrhage J:36250
pale liver J:36250
pale yolk sac J:36250
pallor J:36250
spinal hemorrhage J:36250
Cbfbtm1Tok/Cbfbtm1Tok
Tg(Gata1-Cbfb)1Tok/0
involves: 129P2/OlaHsd * C57BL/6J 		abnormal bone ossification J:80668
abnormal chest morphology J:80668
abnormal definitive hematopoiesis J:80668
abnormal intramembranous bone ossification J:80668
abnormal long bone hypertrophic chondrocyte zone J:80668
absent clavicle J:80668
absent T cells J:80668
arrested osteoblast differentiation J:80668
normal cardiovascular system phenotype J:80668
decreased lymphocyte cell number J:80668
delayed endochondral bone ossification J:80668
perinatal lethality, complete penetrance J:80668
proportional dwarf J:80668
respiratory failure J:80668
short limbs J:80668
small spleen J:80668
small thymus J:80668
Cbfbtm2.1Ddg/Cbfbtm2.1Ddg
H2az2Tg(Wnt1-cre)11Rth/H2az2+
involves: 129S6/SvEvTac * C57BL/6J * CBA/J 		abnormal craniofacial development J:226826
perinatal lethality J:226826
Cbfbtm2.1Spe/Cbfbtm2.1Spe
involves: 129S4/SvJae 		abnormal axial skeleton morphology J:124224
abnormal clavicle morphology J:124224
abnormal cranium morphology J:124224
abnormal limb bone morphology J:124224
abnormal long bone diaphysis morphology J:124224
abnormal mandible morphology J:124224
abnormal maxilla morphology J:124224
abnormal metacarpal bone morphology J:124224
abnormal metatarsal bone morphology J:124224
abnormal neurocranium morphology J:124224
abnormal pectoral girdle bone morphology J:124224
abnormal phalanx morphology J:124224
abnormal rib morphology J:124224
abnormal scapula morphology J:124224
abnormal skeleton development J:124224
abnormal splenic cell ratio J:124224
abnormal sternum morphology J:124224
abnormal T cell differentiation J:124224
abnormal thymus cell ratio J:124224
abnormal thymus morphology J:124224
abnormal vertebrae development J:124224
decreased double-positive T cell number J:124224
increased CD4-positive, alpha-beta T cell number J:124224
neonatal lethality, complete penetrance J:124224
thymus hypoplasia J:124224
Cbfbtm2Itan/Cbfbtm2Itan
Not Specified 		abnormal lymph organ development J:168918
abnormal peripheral lymph node morphology J:168918
absent Peyer's patches J:168918
decreased Peyer's patch number J:168918
Cbfbtm2Ppl/Cbfbtm2Ppl
involves: 129S6/SvEvTac 		abnormal chondrocyte morphology J:80669
delayed bone ossification J:80669
neonatal lethality, complete penetrance J:79376, J:80669
short tibia J:80669
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
10/29/2024
MGI 6.24 		The Jackson Laboratory