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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Runx1
runt related transcription factor 1
MGI:99852
141 phenotypes from 32 alleles in 28 genetic backgrounds
Export: Excel File
Allelic Composition
Genetic Background		 Annotated Term Reference
Pdgfratm1.1(cre/Esr1*)Nshk/Pdgfra+
Runx1tm1Medv/Runx1tm1Medv
involves: 129P2/OlaHsd * C57BL/6NCrlj * CBA/JNCrlj 		abnormal hematopoietic cell number J:193389
anemia J:193389
embryonic lethality during organogenesis, complete penetrance J:193389
pallor J:193389
Runx1tm1(cre/Esr1*)Ims/Runx1+
either: (involves: C57BL/6 * CBA) or (involves: C57BL/6 * CBA * ICR) 		normal hematopoietic system phenotype J:121435
Runx1tm1(cre/Esr1*)Ims/Runx1tm1(cre/Esr1*)Ims
involves: C57BL/6 * CBA 		neonatal lethality J:182232
Runx1tm1(RUNX1)Gcg/Runx1tm1(RUNX1)Gcg
Tg(Mx1-cre)1Cgn/0
involves: 129S1/Sv * C57BL/6 * CBA 		abnormal granulocyte differentiation J:106800
abnormal myelopoiesis J:106801
abnormal T cell differentiation J:106800
anemia J:106800
decreased CD4-positive, alpha-beta T cell number J:106800
decreased double-positive T cell number J:106800
increased CD8-positive, alpha-beta T cell number J:106800
increased metastatic potential J:106800
increased T cell derived lymphoma incidence J:106800
Runx1tm1.1Glac/Runx1tm1.1Glac
involves: 129P2/OlaHsd * C57BL/6 * ICR 		normal embryo phenotype J:155698
normal hematopoietic system phenotype J:155698
normal mortality/aging J:155698
Runx1tm1.1Gss/Runx1tm1.1Gss
involves: 129S4/SvJae * C57BL/6 		abnormal definitive hematopoiesis J:157660
decreased hematopoietic stem cell number J:157660
embryonic lethality during organogenesis, complete penetrance J:157660
hemorrhage J:157660
pale liver J:157660
Runx1tm1.1Medv/Runx1tm1.1Medv
involves: 129P2/OlaHsd 		no abnormal phenotype detected J:106769
Runx1tm1.1Stkd/Runx1tm1.1Stkd
Tg(Col2a1-cre)1Star/0
involves: C57BL/6 		normal skeleton phenotype J:158761
Runx1tm1.1Stkd/Runx1tm1.1Stkd
Tg(Prrx1-cre)1Cjt/0
involves: C57BL/6J * SJL/J 		abnormal bone mineralization J:158761
abnormal skeleton development J:158761
abnormal sternum morphology J:158761
abnormal xiphoid process morphology J:158761
Runx1tm1Buch/Runx1tm1Buch
involves: 129P2/OlaHsd 		no abnormal phenotype detected J:68499
Runx1tm1Dow/Runx1+
involves: 129P2/OlaHsd * C57BL/6 		no abnormal phenotype detected J:31130
Runx1tm1Dow/Runx1tm1Dow
involves: 129P2/OlaHsd * C57BL/6 		abnormal embryonic hematopoiesis J:31130
embryonic lethality during organogenesis, complete penetrance J:31130
hemopericardium J:31130
hemoperitoneum J:31130
internal hemorrhage J:31130
intraventricular hemorrhage J:31130
pale liver J:31130
Runx1tm1Itan/Runx1tm1Itan
involves: 129P2/OlaHsd 		normal hematopoietic system phenotype J:132661
normal immune system phenotype J:132661
Runx1tm1Medv/Runx1tm1Medv
involves: 129P2/OlaHsd 		anemia J:106769
embryonic lethality during organogenesis, complete penetrance J:106769
hemorrhage J:106769
impaired hematopoiesis J:106769
Runx1tm1Sata/Runx1tm1Sata
involves: 129S4/SvJae * C57BL/6J 		abnormal angiogenesis J:63424
abnormal definitive hematopoiesis J:50937, J:63424
abnormal erythropoiesis J:63424
abnormal vascular branching morphogenesis J:63424
abnormal vitelline vascular remodeling J:63424
aneurysm J:63424
embryonic lethality during organogenesis, complete penetrance J:50937
hemopericardium J:63424
internal hemorrhage J:63424
intraventricular hemorrhage J:63424
Runx1tm1Sata/Runx1tm1Sata
Tg(Rr438-Runx1)#Mym/0
involves: 129S4/SvJae * C57BL/6 * DBA/2 		abnormal nasal septum morphology J:145189
abnormal palatal shelf fusion at midline J:145189
abnormal palatal shelf morphology J:145189
abnormal primary and secondary palatal fusion J:145189
anterior cleft palate J:145189
lethality throughout fetal growth and development J:145189
Runx1tm1Soga/Runx1tm1.1Soga
Tg(Mx1-cre)1Cgn/0
involves: C57BL/6 * CBA 		abnormal B cell differentiation J:88511
abnormal common myeloid progenitor cell morphology J:88511
abnormal definitive hematopoiesis J:88511
abnormal megakaryocyte differentiation J:88511
abnormal megakaryocyte morphology J:88511
abnormal megakaryocyte progenitor cell morphology J:88511
abnormal T cell differentiation J:88511
normal hematopoietic system phenotype J:88511
thrombocytopenia J:88511
Runx1tm1Spe/Runx1+
either: (involves: 129S4/SvJae * BALB/c * C57BL/6 * CBA/Ca) or (involves: 129S4/SvJae * C57BL/6 * CBA/Ca) 		increased T cell derived lymphoma incidence J:80829
Runx1tm1Spe/Runx1+
either: (involves: 129S4/SvJae * BALB/c) or (involves: 129S4/SvJae * C57BL/6) 		abnormal embryonic hematopoiesis J:120100
decreased CD4-positive, alpha-beta T cell number J:120100
normal neoplasm J:80829
Runx1tm1Spe/Runx1tm1Spe
either: (involves: 129S4/SvJae * BALB/c) or (involves: 129S4/SvJae * C57BL/6) 		abnormal erythropoiesis J:35115
embryo tissue necrosis J:35115
embryonic lethality during organogenesis, complete penetrance J:35115
hemopericardium J:35115
hemorrhage J:35115
impaired hematopoiesis J:35115
impaired myelopoiesis J:35115
increased nucleated erythrocyte cell number J:35115
internal hemorrhage J:35115
Runx1tm1Spe/Runx1tm1Yg
involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6 		anemia J:160791
embryonic lethality J:160791
internal hemorrhage J:160791
Runx1tm1Spe/Runx1tm2Spe
either: (involves: 129S4/SvJae * BALB/c) or (involves: 129S4/SvJae * C57BL/6) 		abnormal embryonic hematopoiesis J:56184
Runx1tm1Spe/Runx1tm3Itan
involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6 		normal hematopoietic system phenotype J:160791
normal mortality/aging J:160791
Runx1tm1Tani/Runx1tm1Tani
Tg(Cd4-cre)1Cwi/?
involves: 129P2/OlaHsd * C57BL/6 * DBA/2 		abnormal CD4-positive T cell differentiation J:125959
abnormal CD8-positive, alpha-beta T cell differentiation J:125959
abnormal double-positive T cell morphology J:125959
decreased CD4-positive, alpha-beta T cell number J:125959
Runx1tm1Tani/Runx1tm1Tani
Tg(Lck-cre)1Cwi/?
involves: 129P2/OlaHsd 		arrested T cell differentiation J:125959
decreased double-positive T cell number J:125959
decreased thymocyte number J:125959
increased double-negative T cell number J:125959
Runx1tm1Yg/Runx1+
Tg(Runx1-GFP)#Itan/0
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA 		abnormal dorsal aorta morphology J:160791
abnormal hematopoietic system morphology/development J:160791
Runx1tm1Yg/Runx1tm1Yg
either: (involves: 129/Sv * 129S1/Sv * 129X1/SvJ) or (involves: 129S1/Sv * 129X1/SvJ * ICR) or (involves: 129S1/Sv * 129X1/SvJ * MF1) 		abnormal definitive hematopoiesis J:125830
abnormal leukopoiesis J:125830
abnormal T cell differentiation J:125830
abnormal thymus corticomedullary boundary morphology J:125830
abnormal thymus lobule morphology J:125830
decreased body size J:125830
decreased single-positive T cell number J:125830
decreased thymocyte number J:125830
increased double-positive T cell number J:125830
increased thymocyte apoptosis J:125830
postnatal lethality, complete penetrance J:125830
slow postnatal weight gain J:125830
small thymus J:125830
thymus cyst J:125830
thymus hypoplasia J:125830
Runx1tm1Yg/Runx1tm1Yg
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 		abnormal bone marrow cell morphology/development J:160791
Runx1tm1Yg/Runx1tm1Yg
Tg(Lck-cre)1Jtak/?
either: (involves: 129/Sv * 129S1/Sv * 129X1/SvJ) or (involves: 129S1/Sv * 129X1/SvJ * ICR) or (involves: 129S1/Sv * 129X1/SvJ * MF1) 		decreased T cell number J:125830
Runx1tm1Yg/Runx1tm1Yg
Tg(Runx1-GFP)#Itan/0
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA 		abnormal dorsal aorta morphology J:160791
abnormal hematopoietic system morphology/development J:160791
Runx1tm1Yg/Runx1tm2Spe
either: (involves: 129/Sv) or (involves: 129/Sv * ICR) or (involves: 129/Sv * MF1) 		embryonic lethality during organogenesis, complete penetrance J:125830
internal hemorrhage J:125830
intracranial hemorrhage J:125830
spinal hemorrhage J:125830
Runx1tm2.1(cre/Esr1*)Ims/Runx1tm1Medv
involves: 129P2/OlaHsd * C57BL/6 		abnormal hematopoietic system morphology/development J:182232
anemia J:182232
embryonic lethality during organogenesis, complete penetrance J:182232
normal hematopoietic system phenotype J:182232
hemorrhage J:182232
neonatal lethality J:182232
Runx1tm2.1(cre/Esr1*)Ims/Runx1tm2.1(cre/Esr1*)Ims
involves: C57BL/6 		anemia J:182232
embryonic lethality during organogenesis, complete penetrance J:182232
hemorrhage J:182232
Runx1tm2.1Gss/Runx1tm2.1Gss
involves: 129S4/SvJae * C57BL/6 		abnormal definitive hematopoiesis J:214025
abnormal erythrocyte morphology J:214025
abnormal erythroid progenitor cell morphology J:214025
abnormal erythropoiesis J:214025
abnormal leukocyte morphology J:214025
abnormal megakaryocyte differentiation J:214025
abnormal megakaryocyte morphology J:214025
abnormal spleen white pulp morphology J:214025
anemia J:214025
decreased CD8-positive, alpha-beta T cell number J:214025
decreased hematocrit J:214025
decreased immature B cell number J:214025
decreased mean corpuscular volume J:214025
decreased pre-pro B cell number J:214025
enlarged spleen J:214025
normal hematopoietic system phenotype J:214025
increased erythrocyte cell number J:214025
increased granulocyte number J:214025
increased hemoglobin content J:214025
increased macrophage cell number J:214025
increased mature B cell number J:214025
increased mean platelet volume J:214025
increased monocyte cell number J:214025
increased pro-B cell number J:214025
increased red blood cell distribution width J:214025
normal mortality/aging J:214025
myeloid hyperplasia J:214025
thrombocytosis J:214025
Runx1tm2Buch/Runx1tm2Buch
involves: 129P2/OlaHsd * C57BL/6 		no abnormal phenotype detected J:105709
Runx1tm2Buch/Runx1tm2Buch
Tg(Mx1-cre)1Cgn/?
involves: 129P2/OlaHsd * C57BL/6 * CBA 		abnormal common myeloid progenitor cell morphology J:105709
abnormal immune system organ morphology J:105709
abnormal leukocyte morphology J:105709
abnormal lymph node size J:105709
abnormal megakaryocyte morphology J:105709
abnormal thymus lobule morphology J:105709
decreased CD4-positive, alpha-beta T cell number J:105709
decreased CD8-positive, alpha-beta T cell number J:105709
decreased double-positive T cell number J:105709
decreased lymphocyte cell number J:105709
decreased mature B cell number J:105709
decreased megakaryocyte cell number J:105709
decreased spleen white pulp amount J:105709
decreased T cell number J:105709
decreased thymus weight J:105709
impaired myelopoiesis J:105709
increased hematopoietic stem cell number J:105709
increased lymphoma incidence J:105709
increased mast cell number J:105709
increased monocyte cell number J:105709
increased neutrophil cell number J:105709
increased number of Howell-Jolly bodies J:105709
increased spleen red pulp amount J:105709
increased spleen weight J:105709
increased T cell derived lymphoma incidence J:105709
small Peyer's patches J:105709
thrombocytopenia J:105709
Runx1tm2Dow/Runx1+
involves: 129P2/OlaHsd * C57BL/6 		abnormal embryonic hematopoiesis J:79160
embryonic lethality during organogenesis, complete penetrance J:79160
hemopericardium J:79160
intraventricular hemorrhage J:79160
pale liver J:79160
Runx1tm2Itan/Runx1tm2Itan
involves: 129P2/OlaHsd 		normal hematopoietic system phenotype J:132661
normal immune system phenotype J:132661
Runx1tm2Spe/Runx1tm3Spe
Tg(KRT5-cre)5132Jlj/0
either: (involves: 129S4/SvJae * BALB/c * C57BL/6 * DBA/2J) or (involves: 129S4/SvJae * C57BL/6 * DBA/2J) 		abnormal coat appearance J:116050
abnormal zigzag hair morphology J:116050
decreased curvature of zigzag hairs J:116050
increased curvature of auchene hairs J:116050
Runx1tm3.1Spe/Runx1tm3.1Spe
involves: 129S4/SvJae * C57BL/6 		no abnormal phenotype detected J:152374
Runx1tm3Itan/Runx1tm3Itan
involves: 129P2/OlaHsd 		abnormal axillary lymph node morphology J:168918
abnormal inguinal lymph node morphology J:168918
abnormal lymph organ development J:168918
abnormal Peyer's patch morphology J:168918
decreased CD4-positive, alpha-beta T cell number J:168918
decreased Peyer's patch number J:168918
decreased thymocyte number J:168918
small Peyer's patches J:168918
Runx1tm3Itan/Runx1tm3Itan
involves: 129P2/OlaHsd * C57BL/6 		abnormal bone marrow cell morphology/development J:160791
decreased leukocyte cell number J:160791
increased hematopoietic stem cell number J:160791
normal mortality/aging J:160791
thrombocytopenia J:160791
Runx1tm3Itan/Runx1tm3Itan
Tg(Runx1-GFP)#Itan/0
involves: 129P2/OlaHsd * C57BL/6 * CBA 		abnormal dorsal aorta morphology J:160791
abnormal hematopoietic system morphology/development J:160791
Runx1tm3Spe/Runx1tm3Spe
involves: 129/Sv * C57BL/6 		no abnormal phenotype detected J:90431
Runx1tm3Spe/Runx1tm3Spe
Slc17a8tm1(cre)Lowl/Slc17a8+
involves: 129S4/SvJae 		normal behavior/neurological phenotype J:193903
hypoalgesia J:193903
Runx1tm3Spe/Runx1tm3Spe
Tg(Cdh5-cre)1Spe/0
involves: 129S1/SvImJ * 129S4/SvJae * C57BL/6 		abnormal hematopoietic stem cell morphology J:145700
anemia J:145700
decreased hematopoietic stem cell number J:145700
internal hemorrhage J:145700
lethality throughout fetal growth and development, incomplete penetrance J:145700
pale liver J:145700
Runx1tm3Spe/Runx1tm3Spe
Tg(KRT5-cre)5132Jlj/0
either: (involves: 129S4/SvJae * BALB/c * C57BL/6 * DBA/2J) or (involves: 129S4/SvJae * C57BL/6 * DBA/2J) 		abnormal coat appearance J:116050
abnormal zigzag hair morphology J:116050
decreased curvature of zigzag hairs J:116050
increased curvature of auchene hairs J:116050
Runx1tm3Spe/Runx1tm3Spe
Tg(Mx1-cre)1Cgn/0
involves: 129S4/SvJae * C57BL/6 * CBA 		abnormal myeloblast morphology/development J:151639
arrested T cell differentiation J:131217
decreased B cell number J:151639
decreased double-negative T cell number J:131217
decreased hematopoietic stem cell number J:151639
decreased thymus weight J:131217
increased double-negative T cell number J:131217
increased hematopoietic stem cell number J:151639
increased incidence of tumors by chemical induction J:267082
increased spleen weight J:131217
increased susceptibility to induced morbidity/mortality J:267082
thrombocytopenia J:131217
Runx1tm3Spe/Runx1tm3Spe
Tg(VAV1-cre)1Graf/0
involves: 129S4/SvJae 		abnormal common myeloid progenitor cell morphology J:145700
abnormal platelet morphology J:145700
decreased B cell number J:145700
decreased double-positive T cell number J:145700
decreased lymphocyte cell number J:145700
decreased thymocyte number J:145700
increased granulocyte number J:145700
increased hematopoietic stem cell number J:145700
increased monocyte cell number J:145700
Runx1tm4Dow/Runx1tm4Dow
involves: 129P2/OlaHsd 		no abnormal phenotype detected J:89055
Runx1tm4Spe/Runx1+
involves: 129/Sv * C57BL/6 		abnormal embryonic hematopoiesis J:120100
decreased CD4-positive, alpha-beta T cell number J:120100
Runx1tm4Spe/Runx1tm4Spe
involves: 129/Sv * C57BL/6 		abnormal embryonic hematopoiesis J:120100
decreased leukocyte cell number J:120100
decreased lymphocyte cell number J:120100
increased monocyte cell number J:120100
postnatal growth retardation J:120100
postnatal lethality, incomplete penetrance J:120100
thrombocytopenia J:120100
Runx1tm5Spe/Runx1+
involves: 129/Sv * C57BL/6 		abnormal embryonic hematopoiesis J:120100
decreased CD4-positive, alpha-beta T cell number J:120100
Runx1tm5Spe/Runx1tm5Spe
involves: 129/Sv * C57BL/6 		abnormal embryonic hematopoiesis J:120100
embryonic lethality during organogenesis, complete penetrance J:120100
hemopericardium J:120100
hemoperitoneum J:120100
intraventricular hemorrhage J:120100
Runx1tm6Spe/Runx1+
involves: 129/Sv * C57BL/6 		abnormal embryonic hematopoiesis J:120100
decreased CD4-positive, alpha-beta T cell number J:120100
Runx1tm6Spe/Runx1tm6Spe
involves: 129/Sv * C57BL/6 		abnormal embryonic hematopoiesis J:120100
embryonic lethality during organogenesis, complete penetrance J:120100
hemopericardium J:120100
hemoperitoneum J:120100
intraventricular hemorrhage J:120100
Runx1tm7Spe/Runx1+
involves: 129/Sv * C57BL/6 		abnormal embryonic hematopoiesis J:120100
decreased CD4-positive, alpha-beta T cell number J:120100
Runx1tm7Spe/Runx1tm7Spe
involves: 129/Sv * C57BL/6 		abnormal embryonic hematopoiesis J:120100
embryonic lethality during organogenesis, complete penetrance J:120100
hemopericardium J:120100
hemoperitoneum J:120100
intraventricular hemorrhage J:120100
Runx1tm8Spe/Runx1+
involves: 129/Sv * C57BL/6 		abnormal embryonic hematopoiesis J:120100
decreased CD4-positive, alpha-beta T cell number J:120100
Runx1tm8Spe/Runx1tm8Spe
involves: 129/Sv * C57BL/6 		abnormal embryonic hematopoiesis J:120100
lung inflammation J:120100
postnatal growth retardation J:120100
postnatal lethality, complete penetrance J:120100
Slc17a8tm1(cre)Lowl/Slc17a8+
Runx1tm3Spe/Runx1tm3Spe
involves: 129S4/SvJae * 129S6/SvEvTac * C57BL/6NCr 		abnormal sensory neuron innervation pattern J:193903
abnormal sympathetic neuron physiology J:193903
decreased sensory neuron number J:193903
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory