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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Runx1
runt related transcription factor 1
MGI:99852
97 phenotypes from multigenic genotypes
Export: Excel File
Allelic Composition
Genetic Background		 Annotated Term Reference
Bcrtm1(BCR/ABL)Tsr/Bcr+
Runx1tm3Dow/Runx1+
Tg(Vav1-cre)#Cgp/0
involves: C57BL/6 		decreased lymphocyte cell number J:203111
increased monocyte cell number J:203111
increased neutrophil cell number J:203111
premature death J:203111
thrombocytopenia J:203111
Cbfbtm2.1Ddg/Cbfbtm2.1Ddg
Mapttm2Arbr/?
Runx1tm1(cre/Esr1*)Ims/?
involves: 129S6/SvEvTac * C57BL/6NCrlj * CBA/JNCrlj 		abnormal mechanoreceptor morphology J:226826
Etv6tm1(RUNX1)Haho/Etv6+
Runx1tm3Spe/Runx1+
Tg(Mx1-cre)1Cgn/0
involves: 129S1/Sv * 129S4/SvJae * C57BL/6 * CBA 		increased hematopoietic stem cell number J:151639
Etv6tm1(RUNX1)Haho/Etv6+
Runx1tm3Spe/Runx1tm3Spe
Tg(Mx1-cre)1Cgn/0
involves: 129S1/Sv * 129S4/SvJae * C57BL/6 * CBA 		anemia J:151639
decreased hematopoietic stem cell number J:151639
premature death J:151639
Gt(ROSA)26Sortm1(EYFP)Cos/Gt(ROSA)26Sor+
Runx1tm2.1(cre/Esr1*)Ims/Runx1tm1Medv
B6.Cg-Gt(ROSA)26Sortm1(EYFP)Cos Runx1tm2.1(cre/Esr1*)Ims 		abnormal hematopoietic system morphology/development J:182232
normal hematopoietic system phenotype J:182232
H2-Ab1b-tm1Gru/H2-Ab1b-tm1Gru
Runx1tm1Toku/Runx1tm1Toku
Runx3tm1Itan/Runx3tm1Itan
Tg(Cd4-cre)1Cwi/0
involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6 * DBA/2 		abnormal interferon secretion J:131081
increased CD4-positive, alpha-beta T cell number J:131081
Hip1tm4Tsr/Hip1+
Runx1tm3Dow/Runx1+
Tg(Mx1-cre)1Cgn/0
involves: 129X1/SvJ * C57BL/6 * CBA 		abnormal bone marrow cell morphology/development J:151974
abnormal bone marrow cell physiology J:151974
abnormal definitive hematopoiesis J:151974
abnormal liver morphology J:151974
abnormal liver parenchyma morphology J:151974
abnormal lung morphology J:151974
abnormal myelopoiesis J:151974
abnormal spleen B cell follicle morphology J:151974
abnormal spleen morphology J:151974
abnormal tumor morphology J:151974
decreased bone marrow cell number J:151974
decreased common myeloid progenitor cell number J:151974
decreased hematopoietic stem cell number J:151974
enlarged liver J:151974
enlarged spleen J:151974
extramedullary hematopoiesis J:151974
increased chronic myelocytic leukemia incidence J:151974
increased granulocyte number J:151974
increased hematopoietic stem cell number J:151974
increased leukocyte cell number J:151974
increased liver weight J:151974
increased neutrophil cell number J:151974
increased spleen red pulp amount J:151974
increased spleen weight J:151974
postnatal lethality J:151974
spleen hyperplasia J:151974
Hprt1tm1(tetO-Runx1,-EGFP)Enk/Hprt1+
Sox10tm2(rtTA)Weg/Sox10+
involves: 129P2/OlaHsd 		abnormal skin pigmentation J:165939
decreased birth body size J:165939
hyperresponsive to tactile stimuli J:165939
megacolon J:165939
postnatal lethality, complete penetrance J:165939
small dorsal root ganglion J:165939
Mapttm2Arbr/?
Runx1tm3Spe/Runx1tm1(cre/Esr1*)Ims
involves: 129S4/SvJae * C57BL/6NCrlj * CBA/JNCrlj 		abnormal mechanoreceptor morphology J:226826
Mapttm2Arbr/?
Runx1tm3Spe/Runx1tm3Spe
H2az2Tg(Wnt1-cre)11Rth/H2az2+
involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6J * CBA/J 		abnormal axon morphology J:226826
abnormal sensory neuron innervation pattern J:226826
Runx1tm1(RUNX1/EVI1)Kmit/Runx1+
involves: C57BL/6 * CBA 		abnormal embryonic hematopoiesis J:118892
abnormal megakaryocyte morphology J:118892
abnormal myelopoiesis J:118892
decreased erythrocyte cell number J:118892
embryonic lethality during organogenesis, complete penetrance J:118892
intraventricular hemorrhage J:118892
Runx1tm1.1(RUNX1*)Homy/Runx1tm1.1(RUNX1*)Homy
B6.129P2-Runx1tm1.1(RUNX1*)Homy 		abnormal common myeloid progenitor cell morphology J:164806
abnormal megakaryocyte progenitor cell morphology J:164806
abnormal pericyte morphology J:164806
aneurysm J:164806
decreased erythroid progenitor cell number J:164806
decreased hematopoietic cell number J:164806
dilated vasculature J:164806
hemorrhage J:164806
impaired hematopoiesis J:164806
lethality throughout fetal growth and development, complete penetrance J:164806
pale liver J:164806
skin edema J:164806
Runx1tm1.1Stkd/Runx1tm1.1Stkd
Runx2tm1Mjo/Runx2tm1Mjo
Tg(Col2a1-cre)1Star/0
involves: C57BL/6 		abnormal skeleton morphology J:158761
Runx1tm1.1Stkd/Runx1tm1.1Stkd
Runx2tm1Mjo/Runx2tm1Mjo
Tg(Prrx1-cre)1Cjt/0
involves: C57BL/6J * SJL/J 		abnormal bone mineralization J:158761
abnormal chondrocyte differentiation J:158761
abnormal skeleton development J:158761
absent sternum J:158761
preweaning lethality, complete penetrance J:158761
Runx1tm1Dez/Runx1+
involves: 129S4/SvJae * C57BL/6 		embryonic lethality during organogenesis, complete penetrance J:38705
hemorrhage J:38705
impaired hematopoiesis J:38705
Runx1tm1Soga/Runx1tm1Soga
Stag2tm1.1Soga/Y
Tg(Mx1-cre)1Cgn/0
involves: C57BL/6J * C57BL/6N * CBA/J 		abnormal bone marrow cell physiology J:289000
abnormal myeloid cell morphology J:289000
anemia J:289000
decreased erythroid progenitor cell number J:289000
decreased leukocyte cell number J:289000
increased hematopoietic stem cell number J:289000
increased mean corpuscular volume J:289000
increased red blood cell distribution width J:289000
Runx1tm1Tani/Runx1tm1Tani
Runx3tm1Itan/Runx3tm1Itan
Tg(Cd4-cre)1Cwi/?
involves: 129P2/OlaHsd * C57BL/6 * DBA/2 		decreased CD8-positive, alpha-beta T cell number J:125959
Runx1tm1Toku/Runx1+
Runx3tm1Itan/Runx3tm1Itan
Tg(Cd4-cre)1Cwi/0
involves: 129P2/OlaHsd * C57BL/6 * DBA/2 		decreased CD8-positive, alpha-beta T cell number J:131081
Runx1tm1Toku/Runx1tm1Toku
involves: 129P2/OlaHsd * C57BL/6 		abnormal T cell subpopulation ratio J:87697
increased CD4-positive, alpha-beta T cell number J:87697
small thymus J:87697
thymus hypoplasia J:87697
Runx1tm1Toku/Runx1tm1Toku
Runx3tm1Itan/Runx3+
Tg(Cd4-cre)1Cwi/0
involves: 129P2/OlaHsd * C57BL/6 * DBA/2 		decreased CD4-positive, alpha-beta T cell number J:131081
decreased CD8-positive, alpha-beta T cell number J:131081
Runx1tm1Toku/Runx1tm1Toku
Runx3tm1Itan/Runx3tm1Itan
Tg(Cd4-cre)1Cwi/0
involves: 129P2/OlaHsd * C57BL/6 * DBA/2 		decreased CD4-positive, alpha-beta T cell number J:131081
decreased CD8-positive, alpha-beta T cell number J:131081
Runx1tm1Toku/Runx1tm1Toku
Tg(Cd4-cre)1Cwi/0
involves: 129P2/OlaHsd * C57BL/6 * DBA/2 		decreased CD8-positive, alpha-beta T cell number J:131081
Runx1tm2(Runx1)Toku/Runx1tm2(Runx1)Toku
involves: 129P2/OlaHsd * C57BL/6 		abnormal T cell subpopulation ratio J:87697
Runx1tm2.1(Runx1/Mecom)Homy/Runx1+
B6.129P2-Runx1tm2.1(Runx1/Mecom)Homy 		no abnormal phenotype detected J:164806
Runx1tm3(Runx3)Toku/Runx1tm3(Runx3)Toku
involves: 129P2/OlaHsd 		abnormal thymus medulla morphology J:98965
decreased body size J:98965
decreased body weight J:98965
decreased leukocyte cell number J:98965
decreased lymphocyte cell number J:98965
decreased thymocyte number J:98965
postnatal lethality, incomplete penetrance J:98965
small spleen J:98965
small thymus J:98965
thymus hypoplasia J:98965
Runx1tm3Dow/Runx1+
Tg(Mx1-cre)1Cgn/0
involves: C57BL/6 * CBA 		abnormal cell physiology J:77129
abnormal hematopoietic system morphology/development J:77129
decreased tumor-free survival time J:77129
normal hematopoietic system phenotype J:77129
increased acute promyelocytic leukemia incidence J:77129
increased sarcoma incidence J:77129
increased T cell derived lymphoma incidence J:77129
increased tumor incidence J:77129
Runx1tm3Spe/Runx1tm3Spe
Spi1tm2.1Dgt/Spi1tm2.1Dgt
Tg(Mx1-cre)1Cgn/0
involves: 129S4/SvJae * C57BL/6 * CBA 		decreased B cell number J:131217
decreased thymus weight J:131217
increased granulocyte number J:131217
increased spleen weight J:131217
Runx1tm3Spe/Runx1tm3Spe
U2af1tm1.1Hev/U2af1+
Tg(Mx1-cre)1Cgn/0
involves: 129S4/SvJae * 129S6/SvEvTac * BALB/c * C57BL/6 * CBA/J 		abnormal blood cell morphology J:267082
abnormal erythroid lineage cell morphology J:267082
abnormal myeloid cell morphology J:267082
increased incidence of tumors by chemical induction J:267082
increased myeloid cell number J:267082
increased susceptibility to induced morbidity/mortality J:267082
normal mortality/aging J:267082
thrombocytopenia J:267082
Runx1tm4(Runx2)Toku/Runx1tm4(Runx2)Toku
involves: 129P2/OlaHsd 		decreased leukocyte cell number J:98965
Runx1t1tm1Buch/Runx1t1+
Runx1tm1Buch/Runx1+
Tg(Nes-cre)1Atp/0
involves: FVB/N 		no abnormal phenotype detected J:68499
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory