Lama1 Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Lama1
laminin, alpha 1
MGI:99892

51 phenotypes from 9 alleles in 7 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Lama1^{GT(PST008)Byg}/Lama1^{GT(PST008)Byg} involves: 129P2/OlaHsd * C57BL/6	abnormal gastrulation	J:91048
	absent Reichert's membrane	J:91048
	decreased embryo size	J:91048
	embryonic lethality between implantation and somite formation, complete penetrance	J:91048
Lama1^nmf223/Lama1^nmf223 C57BL/6J-Lama1^nmf223/J	abnormal eye electrophysiology	J:160722
	abnormal Muller cell morphology	J:160722
	abnormal ocular fundus morphology	J:160722
	abnormal retina blood vessel morphology	J:160722
	abnormal retina blood vessel pattern	J:160722
	abnormal retina inner limiting membrane morphology	J:160722
	abnormal retina morphology	J:160722
	abnormal retina vasculature morphology	J:160722
	abnormal vitreous body morphology	J:160722
	persistence of hyaloid vascular system	J:160722
	retina spots	J:160722
	thin retina ganglion layer	J:160722
	thin retina inner nuclear layer	J:160722
	vitreal fibroplasia	J:160722
Lama1^nmf223/Lama1^tm1.1Olf involves: 129S2/SvPas * C57BL/6J	abnormal ocular fundus morphology	J:160722
	abnormal retina morphology	J:160722
	abnormal retina vasculature morphology	J:160722
	vitreal fibroplasia	J:160722
Lama1^tm1.1Arhi/Lama1^tm1.1Arhi involves: 129S1/Sv * 129X1/SvJ * C57BL/6	no abnormal phenotype detected	J:184432
Lama1^tm1.1Arhi/Lama1^tm1.2Arhi involves: 129S1/Sv * 129X1/SvJ * C57BL/6	no abnormal phenotype detected	J:184432
Lama1^tm1.1Arhi/Lama1^tm1.2Arhi Edil3^{Tg(Sox2-cre)1Amc}/? involves: 129S1/Sv * 129X1/SvJ * C57BL/6	abnormal Bergmann glial cell morphology	J:184432
	abnormal brain meninges morphology	J:184432
	abnormal brain pia mater morphology	J:184432
	abnormal cerebellar foliation	J:184432
	abnormal cerebellar granule layer morphology	J:184432
	abnormal cerebellar Purkinje cell layer	J:184432
	abnormal cerebellum morphology	J:184432
	abnormal Purkinje cell dendrite morphology	J:184432
	abnormal radial glial cell morphology	J:184432
	impaired coordination	J:184432
	limb grasping	J:184432
	normal mortality/aging	J:184432
	short stride length	J:184432
	small cerebellum	J:184432
Lama1^tm1.1Ekb/Lama1^tm1.1Ekb involves: 129S1/Sv * 129X1/SvJ * C57BL/6	abnormal Reichert's membrane morphology	J:96100
	absent blastocoele	J:96100
	absent Reichert's membrane	J:96100
	embryonic lethality between implantation and somite formation, complete penetrance	J:96100
Lama1^tm1.1Olf/Lama1^tm1.1Olf involves: 129S2/SvPas	abnormal ectoplacental cone morphology	J:102740
	abnormal parietal endoderm morphology	J:102740
	abnormal visceral endoderm morphology	J:102740
	absent Reichert's membrane	J:102740
	embryonic growth retardation	J:102740
	embryonic lethality between implantation and somite formation, complete penetrance	J:102740
	increased embryonic tissue cell apoptosis	J:102740
Lama1^tm1.2Arhi/Lama1^tm1.2Arhi involves: 129S1/Sv * 129X1/SvJ * C57BL/6	absent Reichert's membrane	J:184432
	embryonic lethality between implantation and somite formation, complete penetrance	J:184432
Lama1^tm1Ekb/Lama1^tm1Ekb involves: 129S1/Sv * 129X1/SvJ * C57BL/6	abnormal Reichert's membrane morphology	J:96100
	absent blastocoele	J:96100
	absent Reichert's membrane	J:96100
	embryonic lethality between implantation and somite formation, complete penetrance	J:96100
Lama1^tm1Olf/Lama1^tm1Olf involves: 129S2/SvPas	no abnormal phenotype detected	J:102740
Lama1^tm1Olf/Lama1^tm1Olf Edil3^{Tg(Sox2-cre)1Amc}/Edil3⁺ involves: 129S2/SvPas * C57BL/6J * CBA * CD-1 * Swiss Webster	abnormal Muller cell morphology	J:160722
	abnormal ocular fundus morphology	J:160722
	abnormal retina blood vessel morphology	J:160722
	abnormal retina blood vessel pattern	J:160722
	abnormal retina inner limiting membrane morphology	J:160722
	abnormal retina neuronal layer morphology	J:160722
	abnormal retina vasculature morphology	J:160722
	decreased birth weight	J:160722
	macrophthalmia	J:160722
	normal mortality/aging	J:160722
	persistence of hyaloid vascular system	J:160722
	normal reproductive system phenotype	J:160722
	retina outer nuclear layer degeneration	J:160722
	retina spots	J:160722
	thin retina inner nuclear layer	J:160722
	thin retina inner plexiform layer	J:160722
	vitreal fibroplasia	J:160722
Lama1^{tm2b(EUCOMM)Hmgu}/Lama1⁺ C57BL/6N-Lama1^{tm2b(EUCOMM)Hmgu}/Ieg	abnormal lens morphology	J:211773
	abnormal retina morphology	J:211773
	abnormal retina vasculature morphology	J:211773
	decreased exploration in new environment	J:211773
	increased circulating alanine transaminase level	J:211773
	increased startle reflex	J:211773
	persistence of hyaloid vascular system	J:211773
Lama1^{tm2b(EUCOMM)Hmgu}/Lama1^{tm2b(EUCOMM)Hmgu} C57BL/6N-Lama1^{tm2b(EUCOMM)Hmgu}/Ieg	preweaning lethality, complete penetrance	J:211773

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