Tie1 Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Tie1
tyrosine kinase with immunoglobulin-like and EGF-like domains 1
MGI:99906

29 phenotypes from 7 alleles in 10 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Tie1^tm1.1Scba/Tie1^tm1.1Scba involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * FVB/N	abnormal lymphangiogenesis	J:158668
	abnormal lymphatic vessel morphology	J:158668
	dilated vasculature	J:158668
	edema	J:158668
	hemorrhage	J:158668
	lymphatic vessel hyperplasia	J:158668
	perinatal lethality, complete penetrance	J:158668
	prenatal lethality, incomplete penetrance	J:158668
Tie1^tm1.1Vlcg/Tie1^tm1.1Vlcg involves: 129S6/SvEvTac * C57BL/6NTac	no abnormal phenotype detected	J:200671
Tie1^tm1Geno/Tie1^tm1Geno involves: ICR	abnormal lymphangiogenesis	J:159507
Tie1^tm1Geno/Tie1^tm1Geno involves: ICR	edema	J:159507
Tie1^tm1Geno/Tie1^tm1Geno Tg(ACTFLPe)9205Dym/0 involves: C57BL/6 * ICR * SJL	normal cardiovascular system phenotype	J:159507
Tie1^tm1Jpa/Tie1^tm1Jpa involves: 129S1/Sv * 129X1/SvJ * CD-1	edema	J:30121
	hemorrhage	J:30121
	lethality throughout fetal growth and development, complete penetrance	J:30121
Tie1^tm1Jpa/Tie1^tm1Jpa involves: 129S1/Sv * 129X1/SvJ * ICR	abnormal lymphangiogenesis	J:159507
	normal cardiovascular system phenotype	J:159507
	edema	J:159507
	hemorrhage	J:159507
Tie1^tm1Sato/Tie1^tm1Sato either: (involves: 129S1/Sv * 129T2/SvEmsJ) or (involves: 129S1/Sv * C57BL/6J)	abnormal endocardium morphology	J:26844
	abnormal vascular endothelial cell morphology	J:26844
	embryonic lethality during organogenesis, incomplete penetrance	J:26844
	hemorrhage	J:26844
	intestinal edema	J:26844
	neonatal lethality, complete penetrance	J:26844
	pulmonary edema	J:26844
	respiratory failure	J:26844
	skin edema	J:26844
	small heart	J:26844
Tie1^tm1Sato/Tie1^tm1Sato involves: 129S1/Sv * C57BL/6J	abnormal endocardium morphology	J:79305
	abnormal heart atrium morphology	J:79305
	abnormal pulmonary alveolus morphology	J:79305
	abnormal renal glomerulus morphology	J:79305
	abnormal small intestine morphology	J:79305
	abnormal vascular branching morphogenesis	J:79305
	abnormal vascular endothelial cell development	J:79305
	thick pulmonary interalveolar septum	J:79305
Tie1^tm1Scba/Tie1^tm1Scba involves: 129S1/Sv * 129X1/SvJ * C57BL/6	abnormal lymph circulation	J:158668
	abnormal lymphangiogenesis	J:158668
	abnormal lymphatic vessel morphology	J:158668
	normal cardiovascular system phenotype	J:158668
	edema	J:158668
	hemorrhage	J:158668
	lymphatic vessel hyperplasia	J:158668
	postnatal lethality	J:158668
	prenatal lethality, incomplete penetrance	J:158668
Tie1^tm2Vlcg/Tie1^tm2Vlcg Not Specified	edema	J:200671

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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