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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Lama2
laminin, alpha 2
MGI:99912
87 phenotypes from 8 alleles in 19 genetic backgrounds
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Allelic Composition
Genetic Background		 Annotated Term Reference
Lama2dy-2J/Lama2dy-2J
B6.WK-Lama2dy-2J 		enhanced long-term potentiation J:97464
reduced long-term depression J:97464
Lama2dy-2J/Lama2dy-2J
B6.WK-Lama2dy-2J/J 		abnormal axon radial sorting J:98086
abnormal basal lamina morphology J:134367
abnormal cranium morphology J:129632
abnormal motor coordination/balance J:5000
abnormal myelination J:98086, J:134367
decreased body weight J:5000
enhanced skeletal muscle regeneration J:134367
increased cranium width J:129632
increased variability of skeletal muscle fiber size J:134367
limb grasping J:98086
Lama2dy-2J/Lama2dy-2J
involves: C57BL/6 * FVB/N 		dystrophic muscle J:49435
limb grasping J:49435
Lama2dy-2J/Lama2dy-2J
involves: WK/ReJ 		dystrophic muscle J:5151
hindlimb paralysis J:5151
limb grasping J:5151
opisthotonus J:5151
normal reproductive system phenotype J:5151
Lama2dy-6J/Lama2dy-6J
involves: C57BL/6JEi * DBA/2J 		ataxia J:56803
dystrophic muscle J:56803
kyphosis J:56803
progressive muscle weakness J:56803
Lama2dy-7J/Lama2dy-7J
C57BL/6J-Lama2dy-7J/J 		abnormal basal lamina morphology J:134367
abnormal myelination J:134367
decreased body weight J:134367
demyelination J:82238
dystrophic muscle J:134367
enhanced skeletal muscle regeneration J:134367
hindlimb paresis J:134367
increased variability of skeletal muscle fiber size J:134367
limb grasping J:82238
normal mortality/aging J:134367
muscle spasm J:82238
myopathy J:82238, J:134367
skeletal muscle endomysial fibrosis J:134367
Lama2dy-8J/Lama2dy-8J
C57BL/6J-Lama2dy-8J/GrsrJ 		hindlimb paralysis J:149729
increased or absent threshold for auditory brainstem response J:149729
myopathy J:149729
postnatal lethality, incomplete penetrance J:149729
Lama2dy-Pas/Lama2dy-Pas
involves: non-inbred stock 		abnormal gait J:102806
abnormal joint morphology J:102806
abnormal reflex J:102806
abnormal sexual interaction J:102806
abnormal skeletal muscle morphology J:102806
cachexia J:102806
centrally nucleated skeletal muscle fibers J:102806
decreased body size J:102806
decreased locomotor activity J:102806
dystrophic muscle J:102806
increased variability of skeletal muscle fiber size J:102806
joint contracture J:102806
kyphoscoliosis J:102806
premature death J:102806
skeletal muscle fiber necrosis J:102806
tachypnea J:102806
Lama2dy/Lama2dy
129P1/ReJ-Lama2dy/J 		abnormal axonal transport J:5709
abnormal basement membrane morphology J:5565, J:5866
abnormal galactolipid level J:7911
abnormal lipid level J:7911
abnormal Schwann cell morphology J:12730
decreased body weight J:7911
decreased brain weight J:7911
decreased spinal cord weight J:7911
demyelination J:5331, J:12730
increased cholesterol level J:7911
Lama2dy/Lama2dy
B6.129P1-Lama2dy/J 		abnormal bony labyrinth J:101670
abnormal cochlear hair cell morphology J:101670
abnormal cochlear nerve morphology J:101670
abnormal cranium morphology J:129632
abnormal inner ear vestibule morphology J:101670
abnormal motor capabilities/coordination/movement J:101670
abnormal motor coordination/balance J:5000
abnormal organ of Corti morphology J:101670
abnormal organ of Corti supporting cell morphology J:101670
absent cochlear hair cells J:101670
absent vestibular hair cells J:101670
cochlear degeneration J:101670
decreased body weight J:5000
decreased nerve conduction velocity J:5948
decreased testis weight J:5000
increased circulating prolactin level J:5000
increased cranium width J:129632
increased or absent threshold for auditory brainstem response J:101670
muscle weakness J:101670
stria vascularis degeneration J:101670
Lama2dy/Lama2dy
involves: 129P1/Re 		abnormal sarcolemma morphology J:13125
abnormal sexual interaction J:13125
abnormal skeletal muscle fiber morphology J:13125
ataxia J:13125
cachexia J:13125
centrally nucleated skeletal muscle fibers J:13125
decreased body weight J:13125
dystrophic muscle J:13125
increased variability of skeletal muscle fiber size J:13125
kyphosis J:13125
paresis J:13125
premature death J:13125
progressive muscle weakness J:13125
Lama2dy/Lama2dy
involves: 129P1/Re * C57BL/6 		abnormal basal lamina morphology J:134367
abnormal myelination J:134367
abnormal skeletal muscle fiber morphology J:152525
centrally nucleated skeletal muscle fibers J:152525
decreased skeletal muscle fiber number J:152525
impaired skeletal muscle regeneration J:134367
increased variability of skeletal muscle fiber size J:134367, J:152525
myopathy J:134367
skeletal muscle fiber necrosis J:152525
skeletal muscle interstitial fibrosis J:134367, J:152525
Lama2dy/Lama2dy
involves: 129P1/ReJ 		abnormal muscle physiology J:102959
dystrophic muscle J:102959
increased IgG level J:102959
increased IgM level J:102959
muscle weakness J:102959
postnatal growth retardation J:102959
premature death J:102959
scoliosis J:102959
skeletal muscle interstitial fibrosis J:102959
Lama2tm1Eeng/Lama2tm1Eeng
involves: 129S1/Sv 		decreased body size J:170192
dystrophic muscle J:170192
hindlimb paralysis J:170192
muscle degeneration J:170192
muscle weakness J:170192
myositis J:170192
perinatal lethality, incomplete penetrance J:170192
premature death J:170192
Lama2tm1Eeng/Lama2tm1Eeng
involves: 129S1/Sv * Black Swiss 		dystrophic muscle J:59089
impaired skeletal muscle regeneration J:59089
Lama2tm1Eeng/Lama2tm1Eeng
involves: 129S1/Sv * Black Swiss * FVB/N 		decreased aggression J:49435
decreased body size J:49435
decreased body weight J:49435
dystrophic muscle J:49435
hindlimb paralysis J:49435
limb grasping J:49435
postnatal lethality, incomplete penetrance J:49435
premature death J:49435
Lama2tm1Stk/Lama2tm1Stk
involves: 129/Sv * 129P2/OlaHsd * BALB/c * ICR 		abnormal basal lamina morphology J:43145
abnormal gait J:43145
abnormal skeletal muscle fiber morphology J:43145
abnormal skeletal muscle morphology J:43145
decreased body size J:43145
dystrophic muscle J:43145
increased variability of skeletal muscle fiber size J:43145
muscle spasm J:43145
myopathy J:43145
postnatal growth retardation J:43145
premature death J:43145
Lama2tm1Stk/Lama2tm1Stk
involves: 129P2/OlaHsd 		abnormal basement membrane morphology J:100711
abnormal seminiferous tubule morphology J:100711
abnormal spermatid morphology J:100711
abnormal testis morphology J:100711
Lama2tm1Stk/Lama2tm1Stk
involves: 129P2/OlaHsd * BALB/c 		abnormal thymus corticomedullary boundary morphology J:61802
abnormal thymus physiology J:61802
decreased double-positive T cell number J:61802
decreased T cell number J:61802
thymus cortex hypoplasia J:61802
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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11/19/2024
MGI 6.24 		The Jackson Laboratory